Chem & Bio Engineering,
Год журнала:
2024,
Номер
1(11), С. 916 - 933
Опубликована: Окт. 8, 2024
The
extracellular
matrix
(ECM)
performs
both
as
a
static
scaffold
and
dynamic,
viscoelastic
milieu
that
actively
participates
in
cell
signaling
mechanical
feedback
loops.
Recently,
biomaterials
with
tunable
properties
have
been
utilized
to
mimic
the
native
ECM
fields
of
tissue
engineering
regenerative
medicines.
These
materials
can
be
designed
support
attachment,
proliferation,
differentiation,
facilitating
repair
or
replacement
damaged
tissues.
Moreover,
viscoelasticity
modulation
mimicry
helps
develop
therapeutic
strategies
for
diseases
involving
altered
tissues
such
fibrosis
cancer.
study
biomaterial
thus
intersects
broad
spectrum
biological
medical
disciplines,
offering
insights
into
fundamental
biology
practical
solutions
improving
human
health.
This
review
delves
design
fabrication
hydrogels,
focusing
particularly
on
two
major
parameters,
strength
stress
relaxation,
how
hydrogel
mechanics
influence
interactions
between
living
cells
surrounding
microenvironments.
Meanwhile,
this
discusses
current
bottlenecks
hydrogel-cell
studies,
highlighting
challenges
parameter
decoupling,
long-term
stable
maintenance
microenvironment,
general
applicability
testing
standards
conversion
protocols.
Nonspecific
protein
adsorption
impedes
the
sustainability
of
materials
in
biologically
related
applications.
Such
activates
immune
system
by
quick
identification
allogeneic
and
triggers
a
rejection,
resulting
rapid
failure
implant
drugs.
Antifouling
have
been
rapidly
developed
past
20
years,
from
natural
polysaccharides
(such
as
dextran)
to
synthetic
polymers
polyethylene
glycol,
PEG).
However,
recent
studies
shown
that
traditional
antifouling
materials,
including
PEG,
still
fail
overcome
challenges
complex
human
environment.
Zwitterionic
are
class
contain
both
cationic
anionic
groups,
with
their
overall
charge
being
neutral.
Compared
PEG
zwitterionic
much
stronger
hydration,
which
is
considered
most
important
factor
for
antifouling.
Among
hydrogels
excellent
structural
stability
controllable
regulation
capabilities
various
biomedical
scenarios.
Here,
we
first
describe
mechanism
structure
materials.
Following
preparation
property
hydrogels,
advances
applications
reviewed.
International Journal of Biological Macromolecules,
Год журнала:
2023,
Номер
232, С. 123283 - 123283
Опубликована: Янв. 17, 2023
Hydrogels
have
emerged
as
a
versatile
platform
for
numerous
biomedical
application
due
to
their
ability
absorb
huge
quantity
of
biofluids.
In
order
design
hydrogels,
natural
polymers
are
an
attractive
option
owing
biocompatibility
and
biodegradability.
Due
abundance
in
occurrence,
cost
effectiveness,
facile
crosslinking
approaches,
alginate
has
been
extensively
investigated
fabricate
hydrogel
matrix.
Management
cancer
chronic
wounds
always
challenge
pharmaceutical
healthcare
sector.
both
cases,
curcumin
shown
significant
improvement
effectiveness.
However,
the
innate
restraints
like
poor
bioavailability,
hydrophobicity,
rapid
systemic
clearance
associated
with
restricted
its
clinical
translations.
The
current
review
explores
cascade
research
around
encapsulated
matrix
wound
healing
therapy.
focus
is
emphasize
mechanistic
effects
fate
inside
cells.
Further,
discusses
different
approaches
designed
loaded
hydrogels
along
parameters
that
regulates
release
behavior.
Finally,
concluded
on
some
key
aspect
increasing
efficacy
these
novel
strategies
further
develop
multifacet
applications.
Advanced Materials,
Год журнала:
2023,
Номер
36(13)
Опубликована: Дек. 27, 2023
Abstract
With
the
continuous
development
of
impact
protection
materials,
lightweight,
high‐impact
resistance,
flexibility,
and
controllable
toughness
are
required.
Here,
tough
impact‐resistant
poly(ionic
liquid)
(PIL)/poly(hydroxyethyl
acrylate)
(PHEA)
double‐network
(DN)
elastomers
constructed
via
multiple
cross‐linking
polymer
networks
cation‐π
interactions
PIL
chains.
Benefiting
from
strong
noncovalent
cohesion
achieved
by
in
chains,
prepared
DN
exhibit
extraordinary
compressive
strength
(95.24
±
2.49
MPa)
(55.98
0.66
MJ
m
−3
)
under
high‐velocity
load
(5000
s
−1
).
The
synthesized
elastomer
combines
flexibility
to
protect
fragile
items
impact.
This
strategy
provides
a
new
research
idea
field
next
generation
safety
protective
materials.
eScience,
Год журнала:
2024,
Номер
4(3), С. 100231 - 100231
Опубликована: Янв. 21, 2024
Stimuli-responsive
coordination
polymers
(CPs)
are
among
one
of
the
most
prolific
research
areas
in
developing
next-generation
functional
materials.
Their
capability
being
accurately
excited
by
particular
external
changes
with
pre-determined
and
observable/characterizable
behaviours
correspond,
so
called
"stimuli"
"responsive".
Abundant
types
CP
compounds,
especially
metal-organic
frameworks
(MOFs),
rocketing
interest
owing
to
their
compositional
diversity,
structural
tunability,
essence
highly
engineerable
functionality.
This
present
review
is
aimed
sketch
several
common
stimulation
corresponding
responses
for
CPs,
accompanied
broad
logic
mechanisms
underneath.
And
further
from
aspect
material
revolution,
some
representative
progresses
together
latest
advances
CP-based
materials
various
fields
covered
attempt
display
a
broader
picture
towards
possible
prospects
this
topic.
Polymers,
Год журнала:
2021,
Номер
14(1), С. 20 - 20
Опубликована: Дек. 22, 2021
The
photooxidative
degradation
process
of
plastics
caused
by
ultraviolet
irradiation
leads
to
bond
breaking,
crosslinking,
the
elimination
volatiles,
formation
free
radicals,
and
decreases
in
weight
molecular
weight.
Photodegradation
deteriorates
both
mechanical
physical
properties
affects
their
predicted
life
use,
particular
for
applications
harsh
environments.
Plastics
have
many
benefits,
while
on
other
hand,
they
numerous
disadvantages,
such
as
photodegradation
photooxidation
environments
release
toxic
substances
due
leaching
some
components,
which
a
negative
effect
living
organisms.
Therefore,
attention
is
paid
design
use
safe,
plastic,
stabilizers
that
do
not
pose
danger
environment
if
released.
Plastic
photostabilizers
act
efficient
light
screeners
(absorbers
or
pigments),
excited-state
deactivators
(quenchers),
hydroperoxide
decomposers,
radical
scavengers.
Ultraviolet
absorbers
are
cheap
produce,
can
be
used
low
concentrations,
mix
well
with
polymers
produce
homogenous
matrix,
alter
color
polymers.
Recently,
polyphosphates,
Schiff
bases,
organometallic
complexes
were
synthesized
potential
polymeric
materials.
They
reduced
damage
accelerated
natural
aging,
was
confirmed
inspecting
surface
morphology
irradiated
films.
For
example,
atomic
force
microscopy
revealed
roughness
factor
polymers’
surfaces
improved
significantly
presence
absorbers.
In
addition,
investigation
using
scanning
electron
showed
high
degree
homogeneity
appearance
pores
different
size
shape.
current
work
surveys
first
time
newly
synthesized,
additives
enhance
photostability
materials
and,
particular,
polyvinyl
chloride
polystyrene,
based
mainly
our
own
recent
field.
Abstract
To
minimize
the
environmental
pollution
caused
by
polymeric
waste,
materials
based
dynamic
chemistry
have
attracted
extensive
attention
around
world.
Various
covalent
bonds
or
noncovalent
interactions
been
employed
to
design
multifunctional
polymers
with
recyclability,
reprocessablility,
and
sustainability.
Among
them,
on
reversible
boron–oxygen
(B–O)
widely
investigated
because
of
their
unique
properties.
Particularly,
lots
scientists
demonstrated
that
combination
boron–nitrogen
(B–N)
coordination
can
effectively
accelerate
dynamicity
as
well
enhance
stability
B–O
bonds.
Therefore,
numerous
containing
dative
B–N
designed
synthesized
in
recent
years.
These
exhibit
excellent
versatility
great
potential
for
diverse
applications
such
biosensors,
battery
electrolytes,
artificial
skins.
This
review
provides
an
overview
comprehensive
influence
organoboron
species
highlights
developments
area
constructing
boron‐containing
this
interesting
linkage.
The
guidelines,
existing
challenges,
future
perspectives
burgeoning
field
are
discussed
proposed.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(28), С. 35887 - 35897
Опубликована: Июль 4, 2024
Surgical
operations
are
the
preferred
treatment
for
gastric
perforation
(GP)
but
incur
postoperative
complications
such
as
gastrointestinal
adhesions
and
bacterial
infections,
leading
to
inefficient
wound
healing
serious
that
may
even
threaten
life
of
patient.
Developing
hydrogel
dressings
capable
adapting
environment
(acid)
decreasing
visceral
infections
after
GP
is
crucial.
In
this
article,
we
developed
an
injectable,
self-healing
using
cation–π
interactions
between
protonated
amines
aromatic
rings
under
acidic
conditions
explored
it
repair.
The
hydrogels
demonstrate
exceptional
capabilities
can
be
effectively
tailored
environment.
addition,
demonstrated
significant
efficacy
in
preventing
adhesion,
reducing
inflammation,
promoting
angiogenesis,
facilitating
a
rat
model.
This
novel
demonstrates
adaptability
environment,
rendering
highly
promising
potential
applications
trauma
healing.