Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering DOI Creative Commons

Zi-Yuan Li,

Tianyue Li,

Hao-Chen Yang

et al.

Chem & Bio Engineering, Journal Year: 2024, Volume and Issue: 1(11), P. 916 - 933

Published: Oct. 8, 2024

The extracellular matrix (ECM) performs both as a static scaffold and dynamic, viscoelastic milieu that actively participates in cell signaling mechanical feedback loops. Recently, biomaterials with tunable properties have been utilized to mimic the native ECM fields of tissue engineering regenerative medicines. These materials can be designed support attachment, proliferation, differentiation, facilitating repair or replacement damaged tissues. Moreover, viscoelasticity modulation mimicry helps develop therapeutic strategies for diseases involving altered tissues such fibrosis cancer. study biomaterial thus intersects broad spectrum biological medical disciplines, offering insights into fundamental biology practical solutions improving human health. This review delves design fabrication hydrogels, focusing particularly on two major parameters, strength stress relaxation, how hydrogel mechanics influence interactions between living cells surrounding microenvironments. Meanwhile, this discusses current bottlenecks hydrogel-cell studies, highlighting challenges parameter decoupling, long-term stable maintenance microenvironment, general applicability testing standards conversion protocols.

Language: Английский

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application DOI Creative Commons
Sihang Liu, Jingyi Tang,

Fangqin Ji

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(1), P. 46 - 46

Published: Jan. 7, 2022

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such activates immune system by quick identification allogeneic and triggers a rejection, resulting rapid failure implant drugs. Antifouling have been rapidly developed past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers polyethylene glycol, PEG). However, recent studies shown that traditional antifouling materials, including PEG, still fail overcome challenges complex human environment. Zwitterionic are class contain both cationic anionic groups, with their overall charge being neutral. Compared PEG zwitterionic much stronger hydration, which is considered most important factor for antifouling. Among hydrogels excellent structural stability controllable regulation capabilities various biomedical scenarios. Here, we first describe mechanism structure materials. Following preparation property hydrogels, advances applications reviewed.

Language: Английский

Citations

79
Curcumin-loaded alginate hydrogels for cancer therapy and wound healing applications: A review DOI Creative Commons
Ankur Sood, Atul Dev, Sabya Sachi Das

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 232, P. 123283 - 123283

Published: Jan. 17, 2023

Hydrogels have emerged as a versatile platform for numerous biomedical application due to their ability absorb huge quantity of biofluids. In order design hydrogels, natural polymers are an attractive option owing biocompatibility and biodegradability. Due abundance in occurrence, cost effectiveness, facile crosslinking approaches, alginate has been extensively investigated fabricate hydrogel matrix. Management cancer chronic wounds always challenge pharmaceutical healthcare sector. both cases, curcumin shown significant improvement effectiveness. However, the innate restraints like poor bioavailability, hydrophobicity, rapid systemic clearance associated with restricted its clinical translations. The current review explores cascade research around encapsulated matrix wound healing therapy. focus is emphasize mechanistic effects fate inside cells. Further, discusses different approaches designed loaded hydrogels along parameters that regulates release behavior. Finally, concluded on some key aspect increasing efficacy these novel strategies further develop multifacet applications.

Language: Английский

Citations

56
Poly(Ionic Liquid) Double‐Network Elastomers with High‐Impact Resistance Enhanced by Cation‐π Interactions DOI
Qingning Li, Weizheng Li, Ziyang Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(13)

Published: Dec. 27, 2023

Abstract With the continuous development of impact protection materials, lightweight, high‐impact resistance, flexibility, and controllable toughness are required. Here, tough impact‐resistant poly(ionic liquid) (PIL)/poly(hydroxyethyl acrylate) (PHEA) double‐network (DN) elastomers constructed via multiple cross‐linking polymer networks cation‐π interactions PIL chains. Benefiting from strong noncovalent cohesion achieved by in chains, prepared DN exhibit extraordinary compressive strength (95.24 ± 2.49 MPa) (55.98 0.66 MJ m −3 ) under high‐velocity load (5000 s −1 ). The synthesized elastomer combines flexibility to protect fragile items impact. This strategy provides a new research idea field next generation safety protective materials.

Language: Английский

Citations

49
Stimuli-responsive coordination polymers toward next-generation smart materials and devices DOI Creative Commons

Feifan Lang,

Jiandong Pang, Xian‐He Bu

et al.

eScience, Journal Year: 2024, Volume and Issue: 4(3), P. 100231 - 100231

Published: Jan. 21, 2024

Stimuli-responsive coordination polymers (CPs) are among one of the most prolific research areas in developing next-generation functional materials. Their capability being accurately excited by particular external changes with pre-determined and observable/characterizable behaviours correspond, so called "stimuli" "responsive". Abundant types CP compounds, especially metal-organic frameworks (MOFs), rocketing interest owing to their compositional diversity, structural tunability, essence highly engineerable functionality. This present review is aimed sketch several common stimulation corresponding responses for CPs, accompanied broad logic mechanisms underneath. And further from aspect material revolution, some representative progresses together latest advances CP-based materials various fields covered attempt display a broader picture towards possible prospects this topic.

Language: Английский

Citations

21
Superwetting metal mesh membranes for oil/water separation: A comprehensive review DOI
Nedal Y. Abu-Thabit,

Mahmoud H. Abu Elella,

Abdul Kalam Azad

et al.

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132016 - 132016

Published: Feb. 1, 2025

Language: Английский

Citations

6
Poly (vinyl alcohol)-alginate as potential matrix for various applications: A focused review DOI
Anuj Kumar, Ankur Sood, Sung Soo Han

et al.

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 277, P. 118881 - 118881

Published: Nov. 11, 2021

Language: Английский

Citations

72
Modifications of Polymers through the Addition of Ultraviolet Absorbers to Reduce the Aging Effect of Accelerated and Natural Irradiation DOI Open Access
Gamal A. El‐Hiti, Dina S. Ahmed, Emad͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏ Yousif

et al.

Polymers, Journal Year: 2021, Volume and Issue: 14(1), P. 20 - 20

Published: Dec. 22, 2021

The photooxidative degradation process of plastics caused by ultraviolet irradiation leads to bond breaking, crosslinking, the elimination volatiles, formation free radicals, and decreases in weight molecular weight. Photodegradation deteriorates both mechanical physical properties affects their predicted life use, particular for applications harsh environments. Plastics have many benefits, while on other hand, they numerous disadvantages, such as photodegradation photooxidation environments release toxic substances due leaching some components, which a negative effect living organisms. Therefore, attention is paid design use safe, plastic, stabilizers that do not pose danger environment if released. Plastic photostabilizers act efficient light screeners (absorbers or pigments), excited-state deactivators (quenchers), hydroperoxide decomposers, radical scavengers. Ultraviolet absorbers are cheap produce, can be used low concentrations, mix well with polymers produce homogenous matrix, alter color polymers. Recently, polyphosphates, Schiff bases, organometallic complexes were synthesized potential polymeric materials. They reduced damage accelerated natural aging, was confirmed inspecting surface morphology irradiated films. For example, atomic force microscopy revealed roughness factor polymers’ surfaces improved significantly presence absorbers. In addition, investigation using scanning electron showed high degree homogeneity appearance pores different size shape. current work surveys first time newly synthesized, additives enhance photostability materials and, particular, polyvinyl chloride polystyrene, based mainly our own recent field.

Language: Английский

Citations

60
Toward enabling manufacturing paradigm of 4D printing of shape memory materials: Open literature review DOI Creative Commons
Ijaz Akbar, Mourad El Hadrouz, Mohamed El Mansori

et al.

European Polymer Journal, Journal Year: 2022, Volume and Issue: 168, P. 111106 - 111106

Published: March 7, 2022

Language: Английский

Citations

44
Dynamic polymeric materials based on reversible B–O bonds with dative boron–nitrogen coordination DOI Creative Commons
Zihan Zhao, Cheng‐Hui Li, Jing‐Lin Zuo

et al.

SmartMat, Journal Year: 2023, Volume and Issue: 4(3)

Published: Feb. 21, 2023

Abstract To minimize the environmental pollution caused by polymeric waste, materials based dynamic chemistry have attracted extensive attention around world. Various covalent bonds or noncovalent interactions been employed to design multifunctional polymers with recyclability, reprocessablility, and sustainability. Among them, on reversible boron–oxygen (B–O) widely investigated because of their unique properties. Particularly, lots scientists demonstrated that combination boron–nitrogen (B–N) coordination can effectively accelerate dynamicity as well enhance stability B–O bonds. Therefore, numerous containing dative B–N designed synthesized in recent years. These exhibit excellent versatility great potential for diverse applications such biosensors, battery electrolytes, artificial skins. This review provides an overview comprehensive influence organoboron species highlights developments area constructing boron‐containing this interesting linkage. The guidelines, existing challenges, future perspectives burgeoning field are discussed proposed.

Language: Английский

Citations

25
Cation–π Interaction-Enhanced Self-Healing Injectable Hydrogels for Gastric Perforation Repair DOI
Changyuan He, Siwei Bi, Ruiqi Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(28), P. 35887 - 35897

Published: July 4, 2024

Surgical operations are the preferred treatment for gastric perforation (GP) but incur postoperative complications such as gastrointestinal adhesions and bacterial infections, leading to inefficient wound healing serious that may even threaten life of patient. Developing hydrogel dressings capable adapting environment (acid) decreasing visceral infections after GP is crucial. In this article, we developed an injectable, self-healing using cation–π interactions between protonated amines aromatic rings under acidic conditions explored it repair. The hydrogels demonstrate exceptional capabilities can be effectively tailored environment. addition, demonstrated significant efficacy in preventing adhesion, reducing inflammation, promoting angiogenesis, facilitating a rat model. This novel demonstrates adaptability environment, rendering highly promising potential applications trauma healing.

Language: Английский

Citations

10