Journal of Biomaterials Science Polymer Edition,
Год журнала:
2023,
Номер
34(13), С. 1771 - 1792
Опубликована: Фев. 20, 2023
A
series
of
mussel-inspired
pH-responsive
self-healing
hydrogels
based
on
gelatin
crosslinked
by
oxidized
tannic
acid
(GLT-OTAs)
were
prepared
and
used
as
controlled
drug
delivery
systems
(CDDS).
An
antiphlogistic
drug,
indomethacin
(IDMC)
was
model
to
be
immobilized
into
the
hydrogels.
The
obtained
hydrogel
samples
characterized
Fourier
transform
infrared
(FTIR)
spectroscopy,
X-ray
diffraction
(XRD)
scanning
electron
microscopy
(SEM).
Mechanical
stability,
biocompatibility
property
estimated,
respectively.
Swelling
release
behaviors
these
measured
in
phosphate
buffered
saline
(PBS)
with
pH
7.4
(simulated
intestinal
fluid)
HCl
solution
1.2
gastric
at
37
°C.
Effect
OTA
content
structures
characteristics
all
discussed.
FTIR
spectra
revealed
covalent
cross-linking
between
induced
Michael
addition
Schiff
base
reaction.
Both
XRD
showed
loaded
successfully
existed
steadily.
GLT-OTA
had
satisfactory
biocompatibility,
superior
self-healing.
Results
also
illustrated
that
mechanical
strength,
internal
structure,
swelling
GLT-OTAs
greatly
affected
content.
With
increasing
content,
stability
became
better
better,
their
structure
more
compact.
degree
(SD)
cumulative
tended
decrease
both
obvious
responsiveness.
For
each
sample,
PBS
greater
than
1.2.
These
results
indicated
promising
potential
effective
materials.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(33)
Опубликована: Май 1, 2023
Abstract
Activation
of
cuproptosis
pathway
has
been
reported
to
hold
great
potential
in
the
application
tumor
treatment.
But
efficacy
seriously
limited
by
insufficient
accumulation
sites.
Therefore,
herein
based
on
strong
stabilization
effects
metalloid
element
selenium
(Se)
copper
(Cu),
a
photothermic
Cu
2‐
x
Se
nanoparticle
encapsulated
with
bioresponsive
dimethyl
maleic
anhydride
(DMMA@Cu
Se)
as
copper‐carrier
improve
is
constructed,
thus
achieving
cuproptosis‐driven
enhancement
thermotherapy.
This
nanosystem
exhibits
cellular
uptake
weak
acid‐triggered
charge‐switching
ability.
Next
step,
exposed
oxidized
and
releases
divalent
high‐level
oxide.
Then,
abundant
induces
more
dihydrolipoamide
S
‐acetyltransferase
oligomerization
down‐regulate
FDX1
tricarboxylic
acid
cycle‐related
proteins,
which
leads
inhibiting
aerobic
respiration.
Cuproptosis‐induced
mitochondrial
damage
further
improves
thermotherapy
up‐regulating
reactive
oxygen
species
(ROS).
In
addition,
generated
ROS
also
promotes
release
strengthen
cuproptosis,
eventually
turn.
general,
DMMA@Cu
sequentially
triggered
copper‐release,
efficient
appropriate
photothermal
self‐enhanced
nanoplatform
for
Heliyon,
Год журнала:
2024,
Номер
10(4), С. e26009 - e26009
Опубликована: Фев. 1, 2024
Drug-delivery
systems
(DDSs)
are
designed
to
deliver
drugs
their
specific
targets
minimize
toxic
effects
and
improve
susceptibility
clearance
during
targeted
transport.
Peptides
have
high
affinity,
low
immunogenicity,
simple
amino
acid
composition,
adjustable
molecular
size;
therefore,
most
peptides
can
be
coupled
via
linkers
form
peptide-drug
conjugates
(PDCs)
act
as
active
pro-drugs.
PDCs
widely
thought
promising
DDSs,
given
ability
drug
bio-compatibility
physiological
stability.
Peptide-based
DDSs
often
used
therapeutic
substances
such
anti-cancer
nucleic
acid-based
drugs,
which
not
only
slow
the
degradation
rate
of
in
vivo
but
also
ensure
concentration
at
site
prolong
half-life
vivo.This
article
provides
an
profile
advancements
future
development
functional
peptide-based
delivery
both
domestically
internationally
recent
years,
expectation
achieving
incorporating
taking
full
advantage
synergistic
effects.
Journal of the Egyptian National Cancer Institute,
Год журнала:
2025,
Номер
37(1)
Опубликована: Янв. 6, 2025
Silver
nanoparticles
(AgNPs)
derived
from
natural
sources
have
garnered
significant
attention
due
to
their
unique
properties
and
eco-friendly
production
methods.
With
lung
cancer
remaining
a
major
global
health
issue,
there
is
continuous
need
for
novel
effective
therapeutic
approaches
beyond
conventional
treatments
such
as
chemotherapy,
immunotherapy,
targeted
therapies.
Materials,
Год журнала:
2022,
Номер
15(17), С. 5871 - 5871
Опубликована: Авг. 25, 2022
Peptide-based
hydrogels
have
attracted
increasing
attention
for
biological
applications
and
diagnostic
research
due
to
their
impressive
features
including
biocompatibility
biodegradability,
injectability,
mechanical
stability,
high
water
absorption
capacity,
tissue-like
elasticity.
The
aim
of
this
review
will
be
present
an
updated
report
on
the
advancement
peptide-based
activity
in
recent
years
field
anticancer
drug
delivery,
antimicrobial
wound
healing
materials,
3D
bioprinting
tissue
engineering,
vaccines.
Additionally,
biosensing
key
group
discussed
mainly
focusing
cancer
detection.
ACS Applied Bio Materials,
Год журнала:
2022,
Номер
5(10), С. 4635 - 4651
Опубликована: Май 3, 2022
Stimuli-responsive
peptide-based
biomaterials
are
increasingly
gaining
interest
for
various
specific
and
targeted
treatments,
including
drug
delivery
tissue
engineering.
Among
all
stimuli,
pH
can
be
especially
useful
because
endogenous
changes
often
associated
with
abnormal
microenvironments.
pH-Responsive
amino
acids
organic
linkers
easily
incorporated
into
peptides
that
self-assemble
nanostructures.
Thus,
these
largely
biocompatible
tunable
platforms
ideal
candidates
release
as
fibrous
materials
capable
of
mimicking
the
native
extracellular
matrix.
In
this
review,
we
highlight
common
design
motifs
mechanisms
pH-responsiveness
in
self-assembling
biomaterials,
focusing
on
recent
advances
applied
Finally,
suggest
future
challenges
areas
potential
development
pH-responsive
biomaterials.
Advanced Materials,
Год журнала:
2023,
Номер
36(11)
Опубликована: Дек. 27, 2023
Abstract
Treatment
of
diabetic
wounds
is
a
significant
clinical
challenge
due
to
the
massive
infections
caused
by
bacteria.
In
this
study,
multifunctional
glycol
chitosan
and
polydopamine‐coated
BiO
1‐x
I
(GPBO)
nanoparticles
(NPs)
with
near‐infrared
(NIR)
photothermal
photocatalytic
abilities
are
prepared.
When
infection
occurs,
local
microenvironment
becomes
acidic,
pH‐switchable
GPBO
can
target
bacteria
wound
site.
The
NIR‐assisted
treatment
exhibits
anti‐bacterial
effects
fast
response,
high
efficiency,
long
duration
Escherichia
coli,
Pseudomonas
aeruginosa
,
Staphylococcus
aureus
.
achieves
excellent
imaging
CT
mouse
subcutaneous
abscess
model.
With
assistance
NIR
irradiation,
promotes
healing
model
anti‐bacteria,
anti‐inflammation,
M2
polarization
promotion
macrophages,
angiogenesis.
This
first‐time
report
nano‐sized
I.
synthesis
selected
application
for
targeted
therapy
presented.
study
offers
an
example
NP‐assisted
precise
diagnosis
bacterial
diseases.
Biomaterials Science,
Год журнала:
2023,
Номер
12(1), С. 8 - 56
Опубликована: Окт. 25, 2023
Hydrogels
have
established
their
significance
as
prominent
biomaterials
within
the
realm
of
biomedical
research.
However,
injectable
hydrogels
garnered
greater
attention
compared
with
conventional
counterparts
due
to
excellent
minimally
invasive
nature
and
adaptive
behavior
post-injection.
With
rapid
advancement
emerging
chemistry
deepened
understanding
biological
processes,
contemporary
been
endowed
an
"intelligent"
capacity
respond
various
endogenous/exogenous
stimuli
(such
temperature,
pH,
light
magnetic
field).
This
innovation
has
spearheaded
revolutionary
transformations
across
fields
such
tissue
engineering
repair,
controlled
drug
delivery,
disease-responsive
therapies,
beyond.
In
this
review,
we
comprehensively
expound
upon
raw
materials
(including
natural
synthetic
materials)
principles
these
advanced
hydrogels,
concurrently
providing
a
detailed
discussion
prevalent
strategies
for
conferring
stimulus
responsiveness.
Finally,
elucidate
latest
applications
"smart"
stimuli-responsive
in
domain,
offering
insights
into
prospects.
Self-assembled
peptides
have
been
among
the
important
biomaterials
due
to
its
excellent
biocompatibility
and
diverse
functions.
Over
past
decades,
substantial
progress
breakthroughs
made
in
designing
self-assembled
with
multifaceted
biomedical
applications.
The
techniques
for
quantitative
analysis,
including
imaging-based
techniques,
chromatographic
technique
computational
approach
(molecular
dynamics
simulation),
are
becoming
powerful
tools
exploring
structure,
properties,
applications,
even
supramolecular
assembly
processes
of
peptides.
However,
a
comprehensive
review
concerning
these
remains
scarce.
In
this
review,
recent
investigation
biostability,
cellular
uptake,
biodistribution,
self-assembly
behaviors
peptide
etc.,
summarized.
Specific
applications
roles
highlighted
detail.
Finally,
challenges
outlook
field
concluded.
It
is
believed
that
will
provide
technical
guidance
researchers
peptide-based
materials
pharmaceuticals,
facilitate
related
research
newcomers
field.
