Chemical Communications,
Год журнала:
2022,
Номер
58(67), С. 9409 - 9412
Опубликована: Янв. 1, 2022
Sulfonyl
fluorides
are
emerging
as
key
structural
motifs
in
organic
synthesis,
medicinal
chemistry,
and
materials
science.
Herein
we
report
two
efficient
complementary
methods
for
direct
decarboxylative
fluorosulfonylation
of
carboxylic
acids
by
the
merging
copper
catalysis
with
different
N-centered
HAT
regents.
A
wide
range
structurally
diverse
sulfonyl
was
readily
accessed
from
primary,
secondary,
tertiary
a
single
step
under
mild
conditions.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(6), С. 2313 - 2382
Опубликована: Янв. 1, 2022
Visible-light
photoredox
catalysis
has
been
regarded
as
an
extremely
powerful
tool
in
organic
chemistry,
bringing
the
spotlight
back
to
radical
processes.
The
versatility
of
photocatalyzed
reactions
already
demonstrated
be
effective
providing
alternative
routes
for
cross-coupling
well
multicomponent
reactions.
photocatalyst
allows
generation
high-energy
intermediates
through
light
irradiation
rather
than
using
highly
reactive
reagents
or
harsh
reaction
conditions.
In
a
similar
vein,
electrochemistry
experienced
fruitful
renaissance
generating
without
need
any
catalyst.
Such
milder
approaches
pose
basis
toward
higher
selectivity
and
broader
applicability.
electrochemical
reactions,
species
acts
starter
cascade
events.
This
diverse
reactivity
use
is
usually
not
covered
by
classical
methods.
Owing
availability
cheaper
more
standardized
photo-
reactors,
easily
scalable
flow-setups,
it
surprising
that
these
two
fields
have
become
areas
increased
research
interest.
Keeping
view,
this
review
aimed
at
overview
synthetic
design
MCRs
involving
and/or
activation
crucial
step
with
particular
focus
on
choice
difunctionalized
reagent.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(47)
Опубликована: Июнь 7, 2022
Over
the
past
two
decades,
electro-organic
synthesis
has
gained
significant
interest,
both
in
technical
and
academic
research
as
well
terms
of
applications.
The
omission
stoichiometric
oxidizers
or
reducing
agents
enables
a
more
sustainable
route
for
redox
reactions
organic
chemistry.
Even
if
it
is
well-known
that
every
electrochemical
oxidation
only
viable
with
an
associated
reduction
reaction
vice
versa,
relevance
counter
often
less
addressed.
In
this
Review,
importance
corresponding
highlighted
how
can
affect
performance
selectivity
electrolytic
conversion.
A
selection
common
strategies
unique
concepts
to
tackle
issue
are
surveyed
provide
guide
select
appropriate
synthesis.
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(2), С. 338 - 366
Опубликована: Янв. 18, 2024
This
review
summarizes
examples
of
organic
electrosynthesis
from
the
peer-reviewed
literature
2000
to
2023
that
have
been
conducted
on
scales
20
g
or
above.
A
significant
portion
these
were
a
≤100
scale,
while
detailed
reports
kilogram-scale
remain
scarce
in
pharmaceutical
industry.
In
addition
chemical
transformation,
this
also
highlights
type
reactor
used
and
projected
productivity
metric
as
ways
compare
different
reports.
The
selected
scale-ups
described
herein
illustrate
remaining
challenges
currently
preventing
routine
use
large-scale
ChemSusChem,
Год журнала:
2021,
Номер
14(22), С. 4878 - 4902
Опубликована: Сен. 3, 2021
Sulfones
play
a
pivotal
role
in
modern
organic
chemistry.
They
are
highly
versatile
building
blocks
and
find
various
applications
as
drugs,
agrochemicals,
or
functional
materials.
Therefore,
sustainable
access
to
this
class
of
molecules
is
great
interest.
Herein,
the
goal
was
provide
summary
on
recent
developments
field
sulfone
synthesis.
Advances
existing
limitations
traditional
approaches
towards
sulfones
were
reviewed
selected
examples.
Furthermore,
novel
emerging
technologies
for
more
synthesis
future
directions
discussed.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(37)
Опубликована: Июль 12, 2022
Abstract
Simple
access
to
aryl
sulfinates
from
iodides
and
bromides
is
reported
using
an
inexpensive
Ni‐electrocatalytic
protocol.
The
reaction
exhibits
a
broad
scope,
uses
stock
solution
of
simple
SO
2
as
sulfur
source,
can
be
scaled
up
in
batch
recycle
flow
settings.
limitations
this
are
clearly
shown
put
into
context
by
benchmarking
with
state‐of‐the‐art
Pd‐based
methods.
RSC Advances,
Год журнала:
2022,
Номер
12(10), С. 6214 - 6233
Опубликована: Янв. 1, 2022
Techniques
utilizing
photo-
and
electrochemically
induced
reactions
have
been
developed
to
accelerate
organic
processes.
These
techniques
use
light
or
electrical
energy
(electron
transfer)
as
a
direct
source
without
using
an
initiator
reagent.
Thiocyanates
are
found
in
biologically
active
pharmacological
compounds
can
be
converted
into
various
functional
groups.
It
is
one
of
the
most
prominent
scaffolds.
Significant
development
electro-chemically
thiocyanation
procedures
has
made
recent
years
for
conception
carbon-sulfur
bonds
synthesis
pharmaceutically
important
molecules.
This
review
discusses
different
driven
C(sp
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(39), С. 21189 - 21196
Опубликована: Сен. 20, 2023
The
coupling
of
carboxylic
acids
and
amines
to
form
amide
linkages
is
the
most
commonly
performed
reaction
in
pharmaceutical
industry.
Herein,
we
report
a
new
strategy
that
merges
these
traditional
partners
generate
sulfonamides,
important
bioisosteres.
This
method
leverages
copper
ligand-to-metal
charge
transfer
(LMCT)
convert
aromatic
sulfonyl
chlorides,
followed
by
one-pot
amination
corresponding
sulfonamide.
process
requires
no
prefunctionalization
native
acid
or
amine
extends
diverse
set
aryl,
heteroaryl,
s-rich
aliphatic
substrates.
Further,
extend
this
synthesis
(hetero)aryl
fluorides,
which
have
found
utility
as
"click"
handles
chemical
probes
programmable
bifunctional
reagents.
Finally,
demonstrate
protocols
analogue
synthesis.
Chemical Communications,
Год журнала:
2023,
Номер
59(26), С. 3821 - 3826
Опубликована: Янв. 1, 2023
In
this
highlight,
we
survey
recent
exciting
advances
in
asymmetric
sulfonylation
by
using
sulfur
dioxide
surrogates,
and
discuss
induction
modes,
reaction
mechanisms,
substrate
scope
opportunities
for
further
studies.
