Biomedicines,
Год журнала:
2023,
Номер
11(5), С. 1292 - 1292
Опубликована: Апрель 27, 2023
Skin
cancer
is
one
of
the
most
common
types
cancer,
and
its
incidence
continues
to
increase.
It
divided
into
two
main
categories,
melanoma
non-melanoma.
Treatments
include
surgery,
radiation
therapy,
chemotherapy.
The
relatively
high
mortality
in
existing
recurrence
rates,
both
for
non-melanoma,
create
need
studying
developing
new
approaches
skin
management.
Recent
studies
have
focused
on
immunotherapy,
photodynamic
photothermal
photoimmunotherapy.
Photoimmunotherapy
has
gained
much
attention
due
excellent
potential
outcomes.
combines
advantages
and/or
therapy
with
a
systemic
immune
response,
making
it
ideal
metastatic
cancer.
This
review
critically
discusses
different
nanomaterials’
properties
mechanisms
action
photoimmunotherapy
results
obtained
field.
Biomacromolecules,
Год журнала:
2024,
Номер
25(3), С. 1408 - 1428
Опубликована: Янв. 18, 2024
The
efficacy
of
the
dendritic
cell
(DC)
has
failed
to
meet
expectations
thus
far,
and
crucial
problems
such
as
immature
state
DCs,
low
targeting
efficiency,
insufficient
number
cells,
microenvironment
are
still
current
focus.
To
address
these
problems,
we
developed
two
self-assembling
peptides,
RLDI
RQDT,
that
mimic
extracellular
matrix
(ECM).
These
peptides
can
be
self-assembled
into
highly
ordered
three-dimensional
nanofiber
scaffold
structures,
where
form
gelation
immediately.
In
addition,
found
RQDT
enhance
biological
function
including
releasing
antigens
sustainably,
adhering
promoting
maturation
increasing
ability
DC
antigen
presentation.
Moreover,
peptide
hydrogel-based
treatment
significantly
achieved
prophylactic
effects
on
colon
cancer.
results
have
certain
implications
for
design
new
broad-spectrum
vaccines
in
future.
iScience,
Год журнала:
2022,
Номер
26(1), С. 105789 - 105789
Опубликована: Дек. 10, 2022
Covalently
triggered
peptide
self-assembly
is
achieved
through
sequential
integration
of
spontaneous
covalent
reaction
and
noncovalent
interactions,
thus
both
enhancing
the
physiological
stability
extending
unexpected
functionality
resulting
peptide-based
assemblies,
different
from
popular
supramolecular
merely
associated
with
interactions.
This
review
summarizes
recent
progress
on
development
covalently
for
cancer
theranostics.
Especially,
we
propose
fundamental
design
principle
constructing
a
variety
assemblies
including
nanoparticles,
nanofibers,
hollow
nanospheres,
other
nanoarchitectures.
Subsequently,
discussion
anchored
in
an
overview
representative
assembled
nanodrugs
Finally,
challenges
perspectives
clinical
potential
are
highlighted.
will
provide
new
insights
into
construction
combination
prompt
their
applications
diagnosis
therapeutics.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Triple-negative
breast
cancer
(TNBC)
is
known
for
its
poor
prognosis
and
aggressive
behavior,
being
highly
prone
to
recurrence
metastasis,
currently
has
limited
effective
treatment
options.
Photothermal
therapy
(PTT)
an
emerging,
minimally
invasive,
low-drug-resistance,
precisely
controllable
therapeutic
method
treatment,
offering
hope
break
through
the
bottleneck
in
TNBC
therapy.
The
antitumor
efficiency
of
PTT
predominantly
contingent
upon
performance
photothermal
drugs.
Therefore,
there
urgent
need
develop
drugs
that
not
only
have
excellent
conversion
but
also
possess
strong
tumor-targeting
capabilities
good
biosafety.
Here,
we
developed
a
tumor-targeted
agent
with
near-infrared
(NIR)
absorption
capability
based
on
strategy
biomolecular
assembly,
utilizing
biliverdin
manganese
complexes
(MnBV)
amphiphilic
phospholipid–polymer
conjugates
(DSPE-PEG
DSPE-PEG-cKNGRE).
This
assembled
drug
exhibits
uniform
size,
stability,
ideal
efficiency.
In
4T1
tumor-bearing
mouse
model
TNBC,
it
shows
tumor
dual-targeting
significant
enrichment
performance.
While
ablating
primary
tumor,
further
stimulates
maturation
dendritic
cells
(DCs),
enhancing
infiltration
T
lymphocytes
into
spleen
thus
reshaping
immune
microenvironment
thereby
effectively
inhibiting
metastasis
recurrence.
provides
innovative
candidate
paradigm
potential
advance
precise,
targeted,
safe
invasive
malignancies.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(38)
Опубликована: Июль 21, 2022
Photodynamic
therapy
(PDT)
is
a
highly
promising
therapeutic
modality
for
cancer
treatment.
The
development
of
stimuli-responsive
photosensitizer
nanomaterials
overcomes
certain
limitations
in
clinical
PDT.
Herein,
we
report
the
rational
design
sensitive
PEGylated
photosensitizer-peptide
nanofiber
(termed
PHHPEG
Bioconjugate Chemistry,
Год журнала:
2023,
Номер
34(12), С. 2155 - 2180
Опубликована: Ноя. 13, 2023
Porphyrins
have
been
vastly
explored
and
applied
in
many
cutting-edge
fields
with
plenty
of
encouraging
achievements
because
their
excellent
properties.
As
important
derivatives
porphyrins,
porphyrin-based
amphiphiles
(PBAs)
not
only
maintain
the
advanced
properties
porphyrins
(catalysis,
imaging,
energy
transfer)
but
also
possess
self-assembly
encapsulation
capability
aqueous
solution.
Accordingly,
PBAs
self-assembles
had
roles
diagnosing
treating
tumors
inflammation
lesions
vivo,
limited
to
these.
In
this
article,
we
introduce
research
progress
PBAs,
including
constitution,
structure
design
strategies,
performances
tumor
lesion
diagnosis
treatments.
On
that
basis,
defects
synthesized
during
application
possible
effective
strategies
overcome
limitations
are
proposed.
Finally,
perspectives
on
exploration
updated
based
our
knowledge.
We
hope
review
will
bring
researchers
from
various
domains
insights
about
PBAs.
Immunotherapy,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Март 3, 2025
Light-based
immunotherapy
uses
specific
wavelengths
of
light
to
activate
or
modulate
immune
responses.
It
primarily
employs
two
mechanisms:
direct
activation
cells
and
indirect
modulation
the
tumor
microenvironment
(TME).
Several
light-based
technologies
are
under
investigation
clinical
use
in
immunotherapy,
including
photodynamic
(PDIT)
photothermal
therapy
(PTT).
Optogenetic
tools
have
potential
precisely
control
T-cell
receptor
activation,
cytokine
release,
activity
other
effector
cells.
present
innovative
opportunities
within
realm
immunotherapy.
The
ability
regulate
cell
via
optogenetics,
alongside
improved
targeting
cancer
through
photoimmunotherapy,
signifies
a
transformative
shift
our
strategies
for
modulation.
Although
many
these
remain
experimental
stage
various
applications,
initial
findings
encouraging,
especially
concerning
treatment
Continued
research
trials
essential
fully
harness
capabilities
technology
context
therapy.
Livers,
Год журнала:
2023,
Номер
3(1), С. 121 - 160
Опубликована: Март 13, 2023
With
an
expected
incidence
of
more
than
1
million
cases
by
2025,
liver
cancer
remains
a
problem
for
world
health.
over
90%
cases,
hepatocellular
carcinoma
(HCC)
is
the
most
prevalent
kind
cancer.
In
this
review,
we
presented
range
experimental
therapeutics
patients
with
advanced
HCC,
successes
and
failures
new
treatments,
areas
future
development,
evaluation
dose-limiting
toxicity
in
different
drugs,
safety
profile
dysfunction
related
to
underlying
chronic
disease.
addition
unmet
demand
biomarkers
guide
treatment
decisions
burgeoning
fields
immunotherapy
systemic
therapy
carcinoma,
development
old
including
their
current
advancements,
has
been
reviewed.
This
review
aims
evaluate
updated
optimal
clinical
unresectable
carcinomas
practice,
mainly
through
targeted
therapy.
Although
surgical
can
significantly
enhance
survival
probability
early
intermediate-stage
patients,
it
unsuitable
HCC
due
lack
donors.
Due
severe
toxicity,
few
first-line
anti-HCC
such
as
sorafenib,
are
often
reserved
whom
other
therapies
have
failed.
The
second-line
drugs
usually
alternatives
intolerance
or
resistance.
Consequently,
ongoing
growth
possible
preclinical
studies
on
miRNAs,
lncRNAs,
numerous
signaling
pathway
targets
developing
novel
may
introduce
additional
prospects
HCC.
Expert Opinion on Drug Delivery,
Год журнала:
2022,
Номер
19(7), С. 847 - 860
Опубликована: Июнь 24, 2022
Peptide-based
supramolecular
self-assembly
has
been
demonstrated
to
be
a
flexible
approach
for
the
fabrication
of
programmable
de
novo
nanodrugs
by
employing
synergistic
or
reciprocal
intermolecular
non-covalent
interactions.
This
class
nanomaterials
holds
significant
promise
clinical
translation,
especially
as
cancer
theranostics.In
this
review,
we
describe
concept
theranostic
drug
assembly
That
is,
molecular
drugs
are
formulated
into
nanoscale
and
even
microscale
architectures
peptide-modulated
self-assembly.
A
series
peptide-based
discussed,
with
an
emphasis
on
relation
between
structural
feature
performance.Molecular
design,
manipulation
interactions,
elucidation
structure-function
relationships
not
only
facilitate
implementation
principles
in
development,
but
also
provide
new
means
advancing
anticancer
nanostructured
toward
application.
