Chemical Reviews,
Год журнала:
2022,
Номер
122(24), С. 17479 - 17646
Опубликована: Окт. 14, 2022
Alkenes
and
their
derivatives
are
featured
widely
in
a
variety
of
natural
products,
pharmaceuticals,
advanced
materials.
Significant
efforts
have
been
made
toward
the
development
new
practical
methods
to
access
this
important
class
compounds
by
selectively
activating
alkenyl
C(sp2)–H
bonds
recent
years.
In
comprehensive
review,
we
describe
state-of-the-art
strategies
for
direct
functionalization
sp2
C–H
C–F
until
June
2022.
Moreover,
metal-free,
photoredox,
electrochemical
also
covered.
For
clarity,
review
has
divided
into
two
parts;
first
part
focuses
on
currently
available
using
different
alkene
as
starting
materials,
second
describes
bond
easily
accessible
gem-difluoroalkenes
material.
This
includes
scope,
limitations,
mechanistic
studies,
stereoselective
control
(using
directing
groups
well
metal-migration
strategies),
applications
complex
molecule
synthesis
where
appropriate.
Overall,
aims
document
considerable
advancements,
current
status,
emerging
work
critically
summarizing
contributions
researchers
working
fascinating
area
is
expected
stimulate
novel,
innovative,
broadly
applicable
functionalizations
coming
Green Synthesis and Catalysis,
Год журнала:
2022,
Номер
4(1), С. 20 - 34
Опубликована: Июнь 23, 2022
The
pyrrole
moiety
is
an
important
structural
motif
in
functional
materials,
natural
products,
and
pharmaceuticals.
More
more
synthetic
strategies
toward
pyrroles
have
emerged,
where
various
efficient
building
blocks
are
developed
these
synthons
enable
the
syntheses
of
with
different
numbers
components.
However,
no
review
specifically
summarizes
according
to
type
number
employed
blocks.
To
aid
researchers
design
appropriate
substrates
for
synthesis,
herein
we
summarized
advances
classified
reactions
into
four
categories
components,
which
may
shed
light
on
developing
methods
substituted
pyrroles.
Organic Letters,
Год журнала:
2023,
Номер
25(20), С. 3812 - 3817
Опубликована: Май 17, 2023
Intramolecular
electro-oxidative
addition
of
enamines
or
amides
to
nonactivated
alkynes
was
attained
access
carbonyl-pyrroles
-oxazoles
from
N-propargyl
derivatives.
Organoselenium
employed
as
the
electrocatalyst,
which
played
a
crucial
role
π-Lewis
acid
and
selectively
activated
alkyne
for
successful
nucleophilic
addition.
The
synthetic
strategy
permits
wide
range
substrate
scope
up
93%
yield.
Several
mechanistic
experiments,
including
isolation
selenium-incorporated
intermediate
adduct,
enlighten
electrocatalytic
pathway.
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(28)
Опубликована: Фев. 24, 2023
Using
benzylamines
as
the
C4
source
of
1,4-dihydropyridines
(1,4-DHPs),
a
Cu-catalyzed
oxidative
[1+2+1+2]
cascade
cyclization
for
synthesis
1,4-DHPs
was
firstly
developed.
A
broad
range
easily
available
N,N-dimethyl
enaminones
and
are
employed
smoothly
to
provide
diverse
with
high
efficiency.
This
method
is
performed
by
one-pot
C(sp3
)-H
bond
functionalization/C(sp3
)-N
cleavage/cyclization
strategy
form
simultaneously
two
)-C(sp2
)
bonds,
C(sp2
1,4-DHP
ring.
Organic Letters,
Год журнала:
2024,
Номер
26(20), С. 4189 - 4193
Опубликована: Май 14, 2024
An
efficient
and
practical
tandem
reaction
of
4-arylidene
isoxazol-5-ones
with
enamino
esters
catalyzed
by
an
inexpensive
copper
salt
has
been
established
in
a
ball
mill.
This
innovative
approach
yields
diverse
array
structurally
novel
pyrrole-2-carboxylic
acids,
showing
excellent
tolerance
toward
different
functional
groups.
By
integrating
spiroannulation
ring-opening
aromatization
processes,
this
protocol
introduces
facile
cost-effective
strategy
for
synthesizing
highly
functionalized
pyrrole
derivatives.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(3), С. 1407 - 1416
Опубликована: Янв. 10, 2024
A
novel
chromatography-
and
catalyst-free
methodology
has
been
developed
for
the
synthesis
of
poly
substituted
pyrrole
in
good
yields
via
a
multicomponent
reaction
arylglyoxal,
1,3-dicarbonyl,
indole,
aromatic
amine.
This
strategy
provides
various
advantages
such
as
simple
experimental
workup
procedures,
mild
conditions,
no
added
catalyst,
use
green
solvent,
purification
procedure
pure
product
without
using
column
chromatography.
method
offers
highly
effective
to
synthesize
wide
range
indole–pyrrole
conjugates
one-pot
operation.
