Materials & Design,
Год журнала:
2023,
Номер
233, С. 112231 - 112231
Опубликована: Авг. 9, 2023
Bacterial
infection
continues
to
be
one
of
the
biggest
threats
human
health.
The
therapeutic
effect
is
significantly
reduced
as
a
result
development
super-bacteria-resistant
bacteria
due
overuse
antibiotics
for
conventional
antimicrobial
treatment.
emergence
drug-resistant
makes
it
necessary
develop
new
treatments.
Following
successful
application
photothermal
therapy
in
field
oncology
treatment,
more
and
researchers
are
applying
treatments
achieving
important
results,
especially
treatment
bacterial
infections.
As
non-invasive
anti-infection
method,
has
advantages
broad-spectrum
properties,
short
period,
low
systemic
impact.
In
PTT,
efficacy
strongly
depends
on
different
laser
properties
choice
agents
(PTAs).
purpose
this
review
discuss
most
recent
developments
nanomaterials
that
antibacterial.
We
will
delve
into
principles
spectrum
PTAs
provide
summary
current
synthesis,
classification,
structural
features,
physicochemical
antibacterial
performance
research.
challenges
future
prospects
enhanced
cytotoxicity
investigated.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
Abstract
Bacterial
biofilm‐related
infectious
diseases
severely
influence
human
health.
Under
typical
situations,
pathogens
can
colonize
inert
or
biological
surfaces
and
form
biofilms.
Biofilms
are
functional
aggregates
that
coat
bacteria
with
extracellular
polymeric
substances
(EPS).
The
main
reason
for
the
failure
of
biofilm
infection
treatment
is
low
permeability
enrichment
therapeutic
agents
within
biofilm,
which
results
from
particular
features
matrix
barriers
such
as
negatively
charged
components
highly
viscous
compact
EPS
structures.
Hence,
developing
novel
strategies
enhanced
penetrability
crucial.
Herein,
current
progress
nanotechnology
methods
to
improve
agents’
against
matrix,
regulating
material
morphology
surface
properties,
utilizing
physical
penetration
nano/micromotors
microneedle
patches,
equipping
nanoparticles
degradation
enzymes
signal
molecules,
first
summarized.
Finally,
challenges,
perspectives,
future
implementations
engineered
delivery
systems
manage
infections
presented
in
detail.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(13), С. 4392 - 4442
Опубликована: Янв. 1, 2023
Metal
agents
have
made
incredible
strides
in
preclinical
research
and
clinical
applications,
but
their
short
emission/absorption
wavelengths
continue
to
be
a
barrier
distribution,
therapeutic
action,
visual
tracking,
efficacy
evaluation.
