Chemical Physics Reviews,
Год журнала:
2022,
Номер
3(4)
Опубликована: Ноя. 9, 2022
Metal-centered
(MC)
excited
states
(ESs)
of
3d
transition
metal
complexes
(TMCs)
often
possess
rather
low
energies
so
that
these
represent
the
lowest
energy
ESs.
Additionally,
MC
are
strongly
distorted,
hence
they
efficiently
decay
non-radiatively
to
ground
state.
As
bimolecular
photoinduced
electron
transfer
(PET)
and
(EnT)
processes
require
contact
substrate,
confinement
ES
wavefunction
makes
challenging.
Consequently,
considered
less
useful
as
compared
long-lived
charge
higher
with
wavefunctions
extending
onto
ligands.
Despite
supposed
drawbacks,
some
classes
TMCs
can
successfully
engage
in
PET
EnT
being
photoactive
states.
We
discuss
initial
examples
reactivity
covering
chromium,
manganese,
iron,
cobalt
aim
gain
a
deeper
understanding
identify
decisive
key
parameters.
Finally,
we
present
catalytic
photoredox
using
photosensitizers
suitable
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(32), С. 14420 - 14440
Опубликована: Авг. 4, 2022
There
has
been
emerging
interest
in
the
exploitation
of
photophysical
and
photochemical
properties
transition
metal
complexes
for
diagnostic
therapeutic
applications.
In
this
Perspective,
we
highlight
major
recent
advances
development
luminescent
photofunctional
complexes,
particular,
those
rhenium(I),
ruthenium(II),
osmium(II),
iridium(III),
platinum(II),
as
bioimaging
reagents
phototherapeutic
agents,
with
a
focus
on
molecular
design
strategies
that
harness
modulate
interesting
behavior
complexes.
We
also
discuss
current
challenges
future
outlook
both
fundamental
research
clinical
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(19)
Опубликована: Март 18, 2023
Abstract
The
excited‐state
tuning
of
luminescent
metal–organic
compounds
has
made
great
progress
in
the
fields
optical
imaging,
photocatalysis,
photodynamic
therapy,
light‐emitting
devices,
sensors,
and
so
on.
Although
with
high
luminescence
efficiency
can
be
realized
via
enhanced
molecular
rigidity
heavy‐atom
effect,
their
corresponding
lifetimes
are
still
limited
on
order
a
nanosecond
to
millisecond,
owing
inherent
competition
between
luminous
lifetime.
Therefore,
advanced
applications
(i.e.,
persistent
afterglow
information
security,
anti‐counterfeiting,
smart
materials,
among
others)
related
long
(LPL,
typically
lifetime
larger
than
millisecond)
seriously
hindered.
This
review
gives
timely
systematic
summary
for
realizing
room‐temperature
phosphorescence
(RTP)‐type
thermally
activated
delayed
fluorescence
(TADF)‐type
LPL
during
last
few
years.
Particularly,
based
perspectives
time,
space,
energy
dimensions,
fundamental
materials
design
coordination
assembly
systematically
described
first
time.
Moreover,
internal
external
factors
influencing
properties
terms
efficiency,
lifetime,
color
illustrated.
Last
but
not
least,
challenges
also
discussed
developing
from
compounds.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(13), С. 4392 - 4442
Опубликована: Янв. 1, 2023
Metal
agents
have
made
incredible
strides
in
preclinical
research
and
clinical
applications,
but
their
short
emission/absorption
wavelengths
continue
to
be
a
barrier
distribution,
therapeutic
action,
visual
tracking,
efficacy
evaluation.
Chemical Reviews,
Год журнала:
2023,
Номер
123(16), С. 10135 - 10155
Опубликована: Авг. 3, 2023
Over
the
last
few
decades,
various
forms
of
regulated
cell
death
(RCD)
have
been
discovered
and
were
found
to
improve
cancer
treatment.
Although
there
are
several
reviews
on
RCD
induced
by
photodynamic
therapy
(PDT),
a
comprehensive
summary
covering
metal-based
photosensitizers
(PSs)
as
inducers
has
not
yet
presented.
In
this
review,
we
systematically
summarize
works
PSs
that
induce
different
types
RCD,
including
ferroptosis,
immunogenic
(ICD),
pyroptosis.
The
characteristics
mechanisms
each
explained.
At
end
section,
reported
commonalities
between
inducing
same
is
emphasized,
future
perspectives
novel
discussed
at
review.
Considering
essential
roles
in
therapy,
hope
review
will
provide
stage
for
advances
inducers.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(15)
Опубликована: Фев. 14, 2023
Abstract
Although
metallacycle‐based
supramolecular
photosensitizers
(PSs)
have
attracted
increasing
attention
in
biomedicine,
their
clinical
translation
is
still
hindered
by
inherent
dark
toxicity.
Herein,
we
report
what
to
our
knowledge
the
first
example
of
a
molecular
engineering
approach
building
blocks
metallacycles
for
constructing
series
PSs
(
RuA–RuD
),
with
aim
simultaneously
reducing
toxicity
and
enhancing
phototoxicity,
consequently
obtaining
high
phototoxicity
indexes
(PI).
Detailed
vitro
investigations
demonstrate
that
display
cancer
cellular
uptake
remarkable
antitumor
activity
even
under
hypoxic
conditions.
Notably,
RuD
exhibited
no
displayed
highest
PI
value
(≈406).
Theoretical
calculations
verified
has
largest
steric
hindrance
lowest
singlet‐triplet
energy
gap
(Δ
E
ST
,
0.61
eV).
Further
vivo
studies
confirmed
allows
safe
effective
phototherapy
against
A549
tumors.
Chemical Science,
Год журнала:
2023,
Номер
14(6), С. 1461 - 1471
Опубликована: Янв. 1, 2023
Conventional
photodynamic
therapy
mainly
causes
a
therapeutic
effect
on
the
primary
tumor
through
localized
generation
of
reactive
oxygen
species,
while
metastatic
tumors
remain
poorly
affected.
Complementary
immunotherapy
is
effective
in
eliminating
small,
non-localized
distributed
across
multiple
organs.
Here,
we
report
Ir(iii)
complex
Ir-pbt-Bpa
as
highly
potent
immunogenic
cell
death
inducing
photosensitizer
for
two-photon
against
melanoma.
can
produce
singlet
and
superoxide
anion
radicals
upon
light
irradiation,
causing
by
combination
ferroptosis
death.
In
mouse
model
with
two
physically
separated
melanoma
tumors,
although
only
one
was
irradiated,
strong
reduction
both
observed.
Upon
not
induced
immune
response
CD8
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(13), С. 8991 - 9003
Опубликована: Март 21, 2024
Though
immunogenic
cell
death
(ICD)
has
garnered
significant
attention
in
the
realm
of
anticancer
therapies,
effectively
stimulating
strong
immune
responses
with
minimal
side
effects
deep-seated
tumors
remains
challenging.
Herein,
we
introduce
a
novel
self-assembled
near-infrared-light-activated
ruthenium(II)
metallacycle,
Ru1105
(λem
=
1105
nm),
as
first
example
Ru(II)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
and
reduces
adverse
through
multiple
regulated
approaches,
including
NIR-light
excitation,
increased
reactive
oxygen
species
(ROS)
generation,
selective
targeting
tumor
cells,
precision
organelle
localization,
improved
penetration/retention
capabilities.
Specifically,
demonstrates
excellent
depth-activated
ROS
production
(∼1
cm),
resistance
to
diffusion,
anti-ROS
quenching.
Moreover,
exhibits
promising
results
cellular
uptake
generation
cancer
cells
multicellular
spheroids.
Importantly,
induces
more
efficient
an
ultralow
dose
(10
μM)
compared
conventional
agent,
oxaliplatin
(300
μM).
In
vivo
experiments
further
confirm
Ru1105's
potency
inducer,
eliciting
CD8+
T
depleting
Foxp3+
effects.
Our
research
lays
foundation
for
design
secure
exceptionally
potent
metal-based
agents
immunotherapy.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(3), С. 1207 - 1220
Опубликована: Янв. 10, 2024
Photoactivated
pesticides
(PPs)
have
photodynamic
antimicrobial
activities
and
show
good
environmental
compatibility
slow
resistance
development.
However,
the
disadvantages
of
easy
aggregation,
short
duration,
low
efficiency
seriously
restrict
efficient
application
PPs.
Hollow
mesoporous
copper
sulfide
nanoparticles
(HMCuS
NPs)
with
unique
optical
properties
activity
under
light
irradiation,
which
are
considered
smart
drug
delivery
carriers
due
to
their
water
dispersivity
high
encapsulation
surface
area.
Herein,
novel
acid-responsive
photoactivated
pesticide
nanocapsules
(PPs@HMCuS-CTS
were
established
by
electrostatically
coating
HMCuS
NPs
loaded
PPs
(curcumin
physcion)
chitosan
(CTS).
The
results
showed
that
obtained
had
desirable
(PDI0.25)
release
properties.
PPs@HMCuS-CTS
irradiation
was
more
than
1.47
times
those
alone
mixture
synergistic
activity.
Rainfastness,
safety
assessment,
genotoxicity
evaluation
demonstrated
deposited
1.28
on
plant
foliage
without
any
damage
crop.
Therefore,
based
potential
be
an
safe
system.
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
A
series
of
dinuclear
Ir(III)
complexes
have
been
constructed
for
enhanced
photodynamic
and
photothermal
therapy
(PDT
PTT)
cisplatin-resistant
non-small-cell
lung
cancer.
They
enter
cells
via
caveolar
endocytosis,
target
mitochondria
but
not
nuclear,
generate
both
singlet
oxygen
superoxide
anion,
release
heat
when
exposed
to
infrared
(IR)
irradiation,
thus
inducing
reactive
species
(ROS)-associated
cell
disruption
thermal
ablation.
The
IR-generated
ROS
can
further
activate
caspases,
triggering
apoptosis.
Additionally,
the
deplete
intracellular
glutathione,
lead
lipid
peroxidation,
induce
ferroptosis.
selected
complex
