Analytical Chemistry,
Год журнала:
2022,
Номер
94(31), С. 11089 - 11095
Опубликована: Июль 28, 2022
Cancer
is
a
health
threat
worldwide,
and
it
urgent
to
develop
more
sensitive
cancer
detection
methods.
Herein,
polarity-sensitive
cell
membrane
probe
(named
COP)
was
developed
for
detecting
cells
tumors
sensitively
selectively
at
the
level.
The
shows
strong
polarity-dependent
fluorescence
excellent
targeting
ability
visualize
with
red
non-washing
process.
Notably,
COP
can
light
up
tumor
membranes,
which
reveals
that
membranes
have
lower
polarity
than
normal
membranes.
giant
unilamellar
vesicle
model
imaging
studies
proved
this.
Moreover,
effectively
tumors.
Overall,
this
work
demonstrates
of
quite
different
based
on
this,
probes
be
tumors,
opens
new
way
diagnosis
cellular
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(5), С. 1795 - 1835
Опубликована: Янв. 1, 2022
The
discovery
of
a
near-infrared
(NIR,
650-900
nm)
fluorescent
chromophore
hemicyanine
dye
with
high
structural
tailorability
is
great
significance
in
the
field
detection,
bioimaging,
and
medical
therapeutic
applications.
It
exhibits
many
outstanding
advantages
including
absorption
emission
NIR
region,
tunable
spectral
properties,
photostability
as
well
large
Stokes
shift.
These
properties
are
superior
to
those
conventional
fluorogens,
such
coumarin,
fluorescein,
naphthalimides,
rhodamine,
cyanine.
Researchers
have
made
remarkable
progress
developing
activity-based
multifunctional
probes
based
on
skeletons
for
monitoring
vital
biomolecules
living
systems
through
output
fluorescence/photoacoustic
signals,
integration
diagnosis
treatment
diseases
using
chemotherapy
or
photothermal/photodynamic
therapy
combination
therapy.
achievements
prompted
researchers
develop
more
smart
fluorogen
template.
In
this
review,
we
begin
by
describing
brief
history
dyes,
synthetic
approaches,
design
strategies
functional
probes.
Then,
selected
hemicyanine-based
that
can
detect
ions,
small
biomolecules,
overexpressed
enzymes
diagnostic
reagents
systematically
highlighted.
Finally,
potential
drawbacks
outlook
future
investigation
clinical
medicine
transformation
activatable
also
discussed.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(16), С. 5607 - 5651
Опубликована: Янв. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(6), С. 2011 - 2030
Опубликована: Янв. 1, 2023
Ferroptosis
is
a
form
of
regulatory
cell
death
distinct
from
caspase-dependent
apoptosis
and
visualization
its
process
based
on
fluorescence
imaging
technology
important
for
life
entities.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(18), С. 7752 - 7778
Опубликована: Янв. 1, 2022
Ferroptosis
is
an
iron-dependent,
non-apoptotic
form
of
programmed
cell
death
driven
by
excessive
lipid
peroxidation
(LPO).
Mounting
evidence
suggests
that
the
unique
modality
involved
in
development
and
progression
several
diseases
including
cancer,
cardiovascular
(CVDs),
neurodegenerative
disorders,
etc.
However,
pathogenesis
signalling
pathways
ferroptosis
are
not
fully
understood,
possibly
due
to
lack
robust
tools
for
highly
selective
sensitive
imaging
analytes
complex
living
systems.
Up
now,
various
small-molecule
fluorescent
probes
have
been
applied
as
promising
chemosensors
studying
through
tracking
biomolecules
or
microenvironment-related
parameters
vitro
vivo.
In
this
review,
we
comprehensively
reviewed
recent
ferroptosis,
with
a
focus
on
analytes,
design
strategies
bioimaging
applications.
We
also
provided
new
insights
overcome
major
challenges
emerging
field.
Molecules,
Год журнала:
2022,
Номер
27(8), С. 2443 - 2443
Опубликована: Апрель 10, 2022
Dual-state
emissive
(DSE)
fluorophores
are
organic
dyes
displaying
fluorescence
emission
both
in
dilute
and
concentrated
solution
the
solid-state,
as
amorphous,
single
crystal,
polycrystalline
samples
or
thin
films.
This
comes
contrast
to
vast
majority
of
fluorescent
which
typically
show
intense
but
quenched
media
solid-state
owing
π-stacking
interactions;
a
well-known
phenomenon
called
aggregation-caused
quenching
(ACQ).
On
contrary,
molecular
rotors
with
significant
number
free
rotations
have
been
engineered
strong
aggregated-state
thanks
restriction
intramolecular
motions.
is
concept
aggregation-induced
(AIE).
DSE
far
less
explored
despite
fact
that
they
at
crossroad
ACQ
AIE
phenomena
allow
targeting
applications
(bio-conjugation,
sensing,
imaging)
(organic
electronics,
data
encryption,
lasing,
luminescent
displays).
Excited-State
Intramolecular
Proton
Transfer
(ESIPT)
particularly
suitable
engineer
dyes.
Indeed,
ESIPT
fluorescence,
relies
on
phototautomerism
between
normal
tautomeric
species,
characterized
by
along
large
Stokes’
shift,
an
enhanced
photostability
sensitivity
close
environment,
feature
prone
be
used
bio-sensing.
A
drawback
needs
overcome
their
weak
intensity
solution,
detrimental
motions
excited-state.
Several
strategies
proposed
regard.
In
past
few
years,
growing
examples
DSE-ESIPT
indeed
emerged
literature,
enriching
database
such
attractive
review
aims
brief
concise
overview
exploitation
luminescence
for
optimization
properties.
perspective,
synergistic
approach
synthesis,
spectroscopy
ab
initio
calculations
has
proven
efficient
tool
construction
fluorophores.
Chemical Science,
Год журнала:
2022,
Номер
13(38), С. 11280 - 11293
Опубликована: Янв. 1, 2022
Polymethine
cyanine
dyes,
as
the
most
important
class
of
organic
near-infrared-II
(NIR-II)
fluorophores,
recently
received
increasing
attention
due
to
their
high
molar
extinction
coefficients,
intensive
fluorescence
brightness,
and
flexible
wavelength
tunability
for
fluorescent
bioimaging
applications.
Very
recently,
remarkable
advances
have
been
made
in
development
NIR-II
polymethine
fluorophores
with
improved
optical
performance,
mainly
including
tunable
fluorescence,
water
solubility
stability.
In
this
review,
we
summarize
recent
research
molecular
tailoring
design
strategies
then
emphasize
representative
biosensing
The
potential
challenges
perspectives
emerging
field
are
also
discussed.
This
review
may
provide
guidance
reference
further
high-performance
boost
clinical
translation
future.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(11)
Опубликована: Дек. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
