International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132436 - 132436
Опубликована: Май 16, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 180 - 200
Опубликована: Сен. 27, 2023
Язык: Английский
Процитировано
129
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Язык: Английский
Процитировано
83
Advanced Science, Год журнала: 2023, Номер 10(11)
Опубликована: Фев. 12, 2023
Abstract Photothermal therapy (PTT) has emerged as an attractive technique for the treatment of bacterial infections. However, uncontrolled heat generation in conventional PTT inevitably causes thermal damages to healthy tissues and/or organs. It is thus essential develop a smart and universal strategy regulate photothermal equilibrium temperature preset safe threshold. Herein, thermoresponsive hydrogel‐enabled thermostatic system enhanced healing bacteria‐infected wounds reported. In this system, near‐infrared (NIR)‐triggered by nanomaterials spontaneously transferred hydrogel with lower critical solution (LCST), leading its rapid phase transition forming considerable light‐scattering centers block NIR penetration. Such dynamic reversible process automatically regulates phase‐transition point LCST‐type hydrogel. contrast temperature‐uncontrolled severe damages, provides effective protection on organs, which remarkably accelerates wound efficient eradication. This study establishes smart, simple platform, holding great promise skin
Язык: Английский
Процитировано
78
Advanced Functional Materials, Год журнала: 2024, Номер 34(33)
Опубликована: Май 6, 2024
Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.
Язык: Английский
Процитировано
75
ACS Nano, Год журнала: 2023, Номер 17(21), С. 22106 - 22120
Опубликована: Окт. 30, 2023
Diabetic wounds represent a persistent global health challenge with substantial impact on patients' and overall well-being. Herein, hydrogel system that integrates functionalized gold nanorods (AuNRs) M2 macrophage-derived exosomes (M2-Exos) was developed to achieve an efficient synergistic therapy for diabetic wounds. We introduced ion-cross-linked dissipative network into prefabricated covalent cross-linked (long-chain polymer network), which prepared using AuNRs as specific cross-linker. The ion then the long-chain in situ form structure, imparting antiswelling photothermal effects hydrogel. This integrated effectively scavenged reactive oxygen species levels, inhibited inflammation, promoted angiogenesis, stimulated antibacterial activity through near-infrared (NIR) irradiation. To demonstrate potential of hydrogel, we established experimental animal models oral mucosa ulceration full-thickness skin defects. In vivo results confirmed M2-Exos released from hydrogels played crucial role wound closure. Furthermore, effect NIR eradicated bacterial infections area. Overall, our is promising tool accelerating chronic healing tissue regeneration. study highlights benefits combining bioactive platform satisfactory patients diabetes.
Язык: Английский
Процитировано
52
Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 148949 - 148949
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
38
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129828 - 129828
Опубликована: Янв. 29, 2024
Язык: Английский
Процитировано
34
Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150756 - 150756
Опубликована: Март 26, 2024
Язык: Английский
Процитировано
27
Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159545 - 159545
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
3
Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.
Язык: Английский
Процитировано
2