Octadecyl Gallate and Lipid‐Modified MnSe₂ Nanoparticles Enhance Radiosensitivity in Esophageal Squamous Cell Carcinoma and Promote Radioprotection in Normal Tissues

Advanced Materials, Год журнала: 2024, Номер 36(23)

Опубликована: Фев. 26, 2024

Abstract Radiotherapy, a widely used therapeutic strategy for esophageal squamous cell carcinoma (ESCC), is always limited by radioresistance of tumor tissues and side‐effects on normal tissues. Herein, signature based four core genes cyclic GMP‐AMP synthase‐stimulator interferon (cGAS‐STING) pathway, developed to predict prognosis assess immune infiltration, indicating that the cGAS‐STING pathway radiotherapy efficacy are closely intertwined in ESCC. A novel lipid‐modified manganese diselenide nanoparticle (MnSe 2 ‐lipid) with extraordinarily uniform sphere morphology microenvironment (TME) responsiveness simultaneously overcome reduce radiation. The MnSe encapsulated lipid effectively achieves accumulation. Octadecyl gallate surface forming pH‐responsive metal–phenolic covalent realizes rapid degradation TME. released Mn 2+ promotes radiosensitivity generating reactive oxygen species induced Fenton‐like reaction activating pathway. Spontaneously, selenium strengthens response promoting secretion cytokines increasing white blood cells, performs antioxidant activity radiotherapy. Overall, this multifunctional remedy which responsive TME capable providing pathway‐mediated immunostimulation chemodynamic therapy, radioprotection tissues, highlighted here optimize ESCC treatment.

Язык: Английский

---

A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(37)

Опубликована: Май 22, 2024

Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8

Язык: Английский

---

Hydrogen‐Bonded Organic Framework Nanoscintillators for X‐Ray‐Induced Photodynamic Therapy in Hepatocellular Carcinoma

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract X‐ray induced photodynamic therapy (X‐PDT) leverages penetrating to generate singlet oxygen ( 1 O 2 ) for treating deep‐seated tumors. However, conventional X‐PDT typically relies on heavy metal inorganic scintillators and organic photosensitizers produce , which presents challenges related toxicity energy conversion efficiency. In this study, highly biocompatible phosphorescent nanoscintillators based hydrogen‐bonded frameworks (HOF) are designed engineered, termed BPT‐HOF@PEG, enhance in hepatocellular carcinoma (HCC) treatment. BPT‐HOF@PEG functions simultaneously as both scintillator photosensitizer, effectively absorbing transferring abundant . Both vitro vivo investigations demonstrate that internalized efficiently produces significant quantities of upon irradiation. Additionally, exposure directly inflicts DNA damage, the synergistic effects these mechanisms result pronounced cell death substantial tumor growth inhibition, with a inhibition rate up 90.4% assessments. RNA sequencing analyses reveal induces apoptosis Hepa1‐6 cells while inhibiting proliferation, culminating death. Therefore, work highlights considerable potential efficient HOF nanoscintillators‐based promising therapeutic approach HCC, providing effective alternative negligible patients unresectable

Язык: Английский

---

Anaerobic Probiotics-in situ Se nanoradiosensitizers Selectively Anchor to Tumor with Immuno-regulations for Robust Cancer Radio-immunotherapy

Biomaterials, Год журнала: 2025, Номер 318, С. 123117 - 123117

Опубликована: Янв. 21, 2025

Язык: Английский

---

Anion exchange regulated charge separation engineering in bismuth nanoflowers for sonocatalytic radio-immunotherapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 687, С. 801 - 816

Опубликована: Фев. 17, 2025

Язык: Английский

---

Regulation of Ion Homeostasis for Enhanced Tumor Radio‐Immunotherapy

Advanced Science, Год журнала: 2023, Номер 10(32)

Опубликована: Сен. 22, 2023

Intra/extracellular ion content affects the growth and metastasis of tumor cells, as well efficacy various antitumor therapies. Herein, a carbonic anhydrase inhibitor (CAI) is loaded onto pH-responsive calcium carbonate (CaCO3 ) nanoparticles then modify theses with liposomes to obtain biocompatible CaCO3 /CAI@Lipsome (CCL) for enhance radio-immunotherapy. CCL can specially decompose in microenvironment, releasing (Ca2+ CAI, increasing pH value extracellular fluid. CAI restrains flow hydrogen (H+ inside outside resulting reversal acidic microenvironment increase intracellular H+ , both which improve sensitivity radiotherapy. Afterward, increased together radiotherapy-causes reactive oxygen species promotes influx, leading cellular overload. Moreover, CCL-tailored Ca2+ strengthens radiotherapy-induced immunogenic cell death dendritic maturation, amplifying systemic anti-tumor adaptive immunity. Meanwhile, macrophages CCL-treated tumors are polarized from pro-tumor M2 M1 under X-ray exposure, owing neutralization enhances content. Therefore, multi-directional regulation intra/extra pH/calcium by simple nano-preparation would provide powerful way

Язык: Английский

---

Engineering nanosystems for ROS-bridged cancer cascade therapy

Chemical Engineering Journal, Год журнала: 2023, Номер 473, С. 145415 - 145415

Опубликована: Авг. 12, 2023

Язык: Английский

---

Nanodrug Delivery Systems in Antitumor Immunotherapy

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Cancer has become one of the most important factors threatening human health, and global cancer burden been increasing rapidly. Immunotherapy another clinical research hotspot after surgery, chemotherapy, radiotherapy because its high efficiency tumor metastasis prevention. However, problems such as lower immune response rate immune-related adverse reaction in application immunotherapy need to be urgently solved. With development nanodrug delivery systems, various nanocarrier materials have used antitumor with encouraging therapeutic results. In this review, we mainly summarized combination systems from following 4 aspects: (a) combined cytokine therapy improve cytokines vivo; (b) provided a suitable platform for checkpoint blockade other treatments; (c) helped deliver antigens adjuvants vaccines enhance effects; (d) improved treatment reduced toxicity adoptive cell therapy. Nanomaterials chosen by researchers construct their function were also introduced detail. Finally, discussed current challenges future prospects combining immunotherapy.

Язык: Английский

---

Light-driven sextuple theranostics: nanomedicine involving second near-infrared AIE-active Ir(III) complex for prominent cancer treatment

Science China Chemistry, Год журнала: 2024, Номер 67(7), С. 2314 - 2324

Опубликована: Июнь 11, 2024

Язык: Английский

---

Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

Nanoscale, Год журнала: 2024, Номер 16(9), С. 4392 - 4406

Опубликована: Янв. 1, 2024

This review summarizes the amplification effect of SNAs in various combined therapy treatment strategies and highlights recent advances clinical translation.

Язык: Английский

---