Bioinorganic Chemistry and Applications,
Journal Year:
2022,
Volume and Issue:
2022(1)
Published: Jan. 1, 2022
Solid
tumors
have
a
unique
tumor
microenvironment
(TME),
which
includes
hypoxia,
low
acidity,
and
high
hydrogen
peroxide
glutathione
(GSH)
levels,
among
others.
These
factors,
offer
favourable
microenvironments
nourishment
for
development
spread,
also
serve
as
gateway
specific
successful
cancer
therapies.
A
good
example
is
metal
structures
been
synthesized
utilized
to
enhance
oxygen
supply
they
shown
great
promise
in
the
alleviation
of
hypoxia.
In
hypoxic
environment,
certain
oxygen‐dependent
treatments
such
photodynamic
therapy
radiotherapy
fail
respond
therefore
modulating
has
found
antitumor
impact
drugs.
Under
acidic
environments,
produced
by
reaction
peroxides
with
water
not
only
induces
oxidative
stress
but
produces
additional
oxygen.
This
achieved
since
acts
reactive
substrate
molecules
catalyse
enzymes,
alleviating
hypoxia
observed
microenvironment.
Metal
ions
released
process
can
distinct
bioactivity
their
own
right.
used
anticancer
are
rapidly
evolving
field,
there
evidence
that
option
regulating
therapy.
this
regard,
synthesis
mechanisms
behind
application
specifically
target
highlighted
review.
Various
characteristics
TME
angiogenesis,
inflammation,
acidity
ion
homeostasis
addressed
together
forms
synergistic
combination
treatments.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
67, P. 102906 - 102906
Published: Oct. 4, 2023
Microvascular
endothelial
damage
caused
by
intestinal
ischemia‒reperfusion
(II/R)
is
a
primary
catalyst
for
microcirculation
dysfunction
and
enterogenous
infection.
Previous
studies
have
mainly
focused
on
how
neutrophil
extracellular
traps
(NETs)
ferroptosis
cause
epithelial
injury,
little
attention
has
been
given
to
NETs,
from
circulatory
neutrophils,
affect
cells
during
II/R.
This
study
aimed
unravel
the
mechanisms
through
which
NETs
microvascular
dysfunction.
We
first
detected
heightened
local
NET
infiltration
around
microvasculature,
accompanied
increased
cell
ferroptosis,
resulting
in
both
human
animal
II/R
models.
However,
administration
of
inhibitor
ferrostatin-1
or
inhibition
via
neutrophil-specific
peptidylarginine
deiminase
4
(Pad4)
deficiency
led
positive
outcomes,
with
reduced
function
recovery.
Moreover,
RNA-seq
analysis
revealed
significant
enrichment
mitophagy-
ferroptosis-related
signaling
pathways
HUVECs
incubated
NETs.
Mechanistically,
elevated
formation
induced
Fundc1
phosphorylation
at
Tyr18
cells,
mitophagy
inhibition,
mitochondrial
quality
control
imbalance,
excessive
ROS
generation
lipid
peroxidation,
Nevertheless,
using
activator
urolithin
A
AAV-Fundc1
transfection
could
reverse
this
process
ameliorate
damage.
demonstrate
that
NETosis
result
microcirculatory
conclude
suppressed
can
mitigate
improving
Fundc1-dependent
mitophagy.
Targeting
be
promising
approach
treating
II/R-induced
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(18), P. 6447 - 6496
Published: Jan. 1, 2023
This
review
highlights
the
use
of
nanoprobes
to
stratify
various
therapeutic
modalities
and
provides
an
outlook
on
challenges
future
directions
for
patient
stratification.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(15), P. 6287 - 6294
Published: April 4, 2023
Mitochondrial
membrane
potential
(MMP)
and
sulfur
dioxide
(SO2)
significantly
affect
the
mitochondrial
state.
In
this
work,
TC-2
TC-8
were
constructed
through
side-chain
engineering,
in
which
bearing
poorer
hydrophobicity
could
localize
on
mitochondria
better.
Interestingly,
short-wave
emission
was
captured
due
to
sensitive
response
of
SO2
(LOD
=
13.8
nM).
Meanwhile,
probe
bind
with
DNA,
presenting
enhanced
long-wave
emission.
Encouragingly,
migrate
from
nucleus
when
MMP
decreased,
accompanied
by
increase
fluorescence
lifetime
(9-fold).
Hence,
be
used
for
dual-channel
monitoring
MMP,
showed
a
completely
different
pathway
commercial
detectors
JC-1/JC-10.
The
cellular
experiments
that
gradually
decreased
reactive
oxygen
species-triggered
oxidative
stress,
level
up-regulated
simultaneously.
Overall,
work
proposed
new
method
investigate
diagnose
mitochondrial-related
diseases.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(11), P. 4570 - 4579
Published: March 5, 2024
Ferroptosis,
as
a
new
form
of
regulated
cell
death,
is
implicated
in
various
physiological
and
pathological
processes.
Developing
single
probe
for
an
independent
analysis
multiple
analytes
related
to
ferroptosis
can
provide
more
accurate
information
simplify
the
detection
procedures,
but
it
faces
great
challenges.
In
this
work,
we
develop
fluorescent
simultaneous
GSH
through
ratiometric
fluorescence
response
microviscosity
via
lifetime
model.
Based
on
reversible
Michael
addition
reaction
between
unsaturated
C═C
bond,
responds
reversibly
with
variation
fast
time
(t1/2
=
4.7
s).
At
same
time,
sensitive
environmental
viscosity
by
changing
its
lifetimes.
The
was
applied
monitor
drug-induced
process
both
classical
Xc–/GSH/GPX4-
DHODH-mediated
defense
mechanisms.
We
hope
that
will
useful
molecular
tool
real-time
live-cell
imaging
dynamics,
which
benefit
unveiling
