Fluorescent probes for lighting up ferroptotic cell death: A review DOI
Xiaopeng Yang, Shiyi Zhang, Miao Lai

et al.

Talanta, Journal Year: 2023, Volume and Issue: 260, P. 124628 - 124628

Published: May 5, 2023

Language: Английский

Near infrared fluorescent probes for detecting and imaging active small molecules DOI

Caiping Ding,

Tian‐Bing Ren

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215080 - 215080

Published: Feb. 21, 2023

Language: Английский

Citations

130
Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses DOI
Kun Peng, Yue Zheng, Wei Xia

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(8), P. 2790 - 2832

Published: Jan. 1, 2023

Organometallics act through specific biomolecular targets or tumor homeostasis perturbation to induce various cell death pathways.

Language: Английский

Citations

100
Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes DOI
Ya‐Lin Qi,

Yunzhan Li,

Ming-Jun Tan

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 486, P. 215130 - 215130

Published: April 10, 2023

Language: Английский

Citations

97
Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy DOI Creative Commons
Chengnan Chu, Xinyu Wang, Chao Yang

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 67, P. 102906 - 102906

Published: Oct. 4, 2023

Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) ferroptosis cause epithelial injury, little attention has been given to NETs, from circulatory neutrophils, affect cells during II/R. This study aimed unravel the mechanisms through which NETs microvascular dysfunction. We first detected heightened local NET infiltration around microvasculature, accompanied increased cell ferroptosis, resulting in both human animal II/R models. However, administration of inhibitor ferrostatin-1 or inhibition via neutrophil-specific peptidylarginine deiminase 4 (Pad4) deficiency led positive outcomes, with reduced function recovery. Moreover, RNA-seq analysis revealed significant enrichment mitophagy- ferroptosis-related signaling pathways HUVECs incubated NETs. Mechanistically, elevated formation induced Fundc1 phosphorylation at Tyr18 cells, mitophagy inhibition, mitochondrial quality control imbalance, excessive ROS generation lipid peroxidation, Nevertheless, using activator urolithin A AAV-Fundc1 transfection could reverse this process ameliorate damage. demonstrate that NETosis result microcirculatory conclude suppressed can mitigate improving Fundc1-dependent mitophagy. Targeting be promising approach treating II/R-induced

Language: Английский

Citations

67
Nanoprobe-based molecular imaging for tumor stratification DOI

Xianbin Ma,

Mingchuan Mao,

Jiaqi He

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

Citations

51
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

7
A TICT-based fluorescent probe for hypochlorous acid and its application to cellular and zebrafish imaging DOI

Sufang Shao,

Taorui Yang,

Yifeng Han

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 392, P. 134041 - 134041

Published: May 29, 2023

Language: Английский

Citations

37
Bifunctional Single-Molecular Fluorescent Probe: Visual Detection of Mitochondrial SO2 and Membrane Potential DOI

Wenming Ai,

Yingcui Bu,

Houshi Huang

et al.

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(15), P. 6287 - 6294

Published: April 4, 2023

Mitochondrial membrane potential (MMP) and sulfur dioxide (SO2) significantly affect the mitochondrial state. In this work, TC-2 TC-8 were constructed through side-chain engineering, in which bearing poorer hydrophobicity could localize on mitochondria better. Interestingly, short-wave emission was captured due to sensitive response of SO2 (LOD = 13.8 nM). Meanwhile, probe bind with DNA, presenting enhanced long-wave emission. Encouragingly, migrate from nucleus when MMP decreased, accompanied by increase fluorescence lifetime (9-fold). Hence, be used for dual-channel monitoring MMP, showed a completely different pathway commercial detectors JC-1/JC-10. The cellular experiments that gradually decreased reactive oxygen species-triggered oxidative stress, level up-regulated simultaneously. Overall, work proposed new method investigate diagnose mitochondrial-related diseases.

Language: Английский

Citations

28
Recent advance in the development of the fluorescent responsive probes for the study of ferroptosis DOI
Baoli Dong,

Shijing Li,

Yan Wang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 168, P. 117327 - 117327

Published: Sept. 23, 2023

Language: Английский

Citations

24
Reversible Dual Fluorescence-Lifetime Imaging of Mitochondrial GSH and Microviscosity: Real-Time Evaluation of Ferroptosis Status DOI
Siyu Wang, Yuchen Qu, Na Shao

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(11), P. 4570 - 4579

Published: March 5, 2024

Ferroptosis, as a new form of regulated cell death, is implicated in various physiological and pathological processes. Developing single probe for an independent analysis multiple analytes related to ferroptosis can provide more accurate information simplify the detection procedures, but it faces great challenges. In this work, we develop fluorescent simultaneous GSH through ratiometric fluorescence response microviscosity via lifetime model. Based on reversible Michael addition reaction between unsaturated C═C bond, responds reversibly with variation fast time (t1/2 = 4.7 s). At same time, sensitive environmental viscosity by changing its lifetimes. The was applied monitor drug-induced process both classical Xc–/GSH/GPX4- DHODH-mediated defense mechanisms. We hope that will useful molecular tool real-time live-cell imaging dynamics, which benefit unveiling

Language: Английский

Citations

16