Near infrared fluorescent probes for detecting and imaging active small molecules

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215080 - 215080

Published: Feb. 21, 2023

Language: Английский

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Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(8), P. 2790 - 2832

Published: Jan. 1, 2023

Organometallics act through specific biomolecular targets or tumor homeostasis perturbation to induce various cell death pathways.

Language: Английский

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Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 486, P. 215130 - 215130

Published: April 10, 2023

Language: Английский

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Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy

Redox Biology, Journal Year: 2023, Volume and Issue: 67, P. 102906 - 102906

Published: Oct. 4, 2023

Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) ferroptosis cause epithelial injury, little attention has been given to NETs, from circulatory neutrophils, affect cells during II/R. This study aimed unravel the mechanisms through which NETs microvascular dysfunction. We first detected heightened local NET infiltration around microvasculature, accompanied increased cell ferroptosis, resulting in both human animal II/R models. However, administration of inhibitor ferrostatin-1 or inhibition via neutrophil-specific peptidylarginine deiminase 4 (Pad4) deficiency led positive outcomes, with reduced function recovery. Moreover, RNA-seq analysis revealed significant enrichment mitophagy- ferroptosis-related signaling pathways HUVECs incubated NETs. Mechanistically, elevated formation induced Fundc1 phosphorylation at Tyr18 cells, mitophagy inhibition, mitochondrial quality control imbalance, excessive ROS generation lipid peroxidation, Nevertheless, using activator urolithin A AAV-Fundc1 transfection could reverse this process ameliorate damage. demonstrate that NETosis result microcirculatory conclude suppressed can mitigate improving Fundc1-dependent mitophagy. Targeting be promising approach treating II/R-induced

Language: Английский

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Nanoprobe-based molecular imaging for tumor stratification

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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A TICT-based fluorescent probe for hypochlorous acid and its application to cellular and zebrafish imaging

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 392, P. 134041 - 134041

Published: May 29, 2023

Language: Английский

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Bifunctional Single-Molecular Fluorescent Probe: Visual Detection of Mitochondrial SO₂ and Membrane Potential

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(15), P. 6287 - 6294

Published: April 4, 2023

Mitochondrial membrane potential (MMP) and sulfur dioxide (SO2) significantly affect the mitochondrial state. In this work, TC-2 TC-8 were constructed through side-chain engineering, in which bearing poorer hydrophobicity could localize on mitochondria better. Interestingly, short-wave emission was captured due to sensitive response of SO2 (LOD = 13.8 nM). Meanwhile, probe bind with DNA, presenting enhanced long-wave emission. Encouragingly, migrate from nucleus when MMP decreased, accompanied by increase fluorescence lifetime (9-fold). Hence, be used for dual-channel monitoring MMP, showed a completely different pathway commercial detectors JC-1/JC-10. The cellular experiments that gradually decreased reactive oxygen species-triggered oxidative stress, level up-regulated simultaneously. Overall, work proposed new method investigate diagnose mitochondrial-related diseases.

Language: Английский

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A naphthalimide-based fluorescent probe with mitochondria targeting for GSH sensing and cancer cell recognition

Dyes and Pigments, Journal Year: 2023, Volume and Issue: 211, P. 111089 - 111089

Published: Jan. 9, 2023

Language: Английский

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Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(4), P. 2238 - 2263

Published: Feb. 2, 2024

Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation iron metabolism and accumulation lipid peroxides. This nonapoptotic mode implicated in various physiological pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. article focuses on ferroptosis-based therapeutic strategies precision covering molecular mechanisms ferroptosis, four major types ferroptosis inducers their inhibitory effects diverse carcinomas, detection fluorescent probes, implementation image-guided therapy. These state-of-the-art tactics manifested enhanced selectivity efficacy malignant carcinomas. Given administration therapy still at burgeoning stage, some challenges future perspectives discussed clinical translation into treatment.

Language: Английский

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