Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(2), С. 55 - 55

Опубликована: Янв. 19, 2023

Hydrogels are three-dimensional crosslinked structures with physicochemical properties similar to the extracellular matrix (ECM). By changing hydrogel’s material type, crosslinking, molecular weight, chemical surface, and functionalization, it is possible mimic mechanical of native tissues. currently used in biomedical pharmaceutical fields for drug delivery systems, wound dressings, tissue engineering, contact lenses. Lately, research has been focused on hydrogels from natural sources. Polysaccharides have drawn attention recent years as a promising biological applications, due their biocompatibility, biodegradability, non-toxicity, excellent properties. Polysaccharide-based can be systems efficient release various types cancer therapeutics, enhancing therapeutic efficacy minimizing potential side effects. This review summarizes hydrogels’ classification, properties, synthesis methods. Furthermore, also covers several important polysaccharides (chitosan, alginate, hyaluronic acid, cellulose, carrageenan) widely and, particular, application treatment.

Язык: Английский

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Mechanical Properties of Alginate Hydrogels Cross-Linked with Multivalent Cations

Polymers, Год журнала: 2023, Номер 15(14), С. 3012 - 3012

Опубликована: Июль 12, 2023

Ionically, cross-linked alginate gels have a potential to be used in wide range of biomedical, environmental and catalytic applications. The study deals with preparation hydrogels various cations the analysis their equilibrium swelling mechanical properties. It is shown that type cross-linking process affects elastic moduli degree gels. experimental data small-amplitude oscillatory tests are fitted model involves two material parameters: modulus polymer network measure its inhomogeneity. influence on these quantities studied numerically. revealed dependence ionically differs from predicted by conventional theory for covalently

Язык: Английский

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Ionotropically-engineered synthesis of mechanically robust hybrid sodium alginate–silica aerogels with enhanced specific surface area for high-capacity and selective dye adsorption from wastewater

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160590 - 160590

Опубликована: Фев. 1, 2025

Язык: Английский

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Cellulose-alginate hydrogels and their nanocomposites for water remediation and biomedical applications

Environmental Research, Год журнала: 2023, Номер 243, С. 117889 - 117889

Опубликована: Дек. 10, 2023

In the last decade, both cellulose and alginate polysaccharides have been extensively utilized for synthesis of biocompatible hydrogels because their alluring characteristics like low cost, biodegradability, hydrophilicity, ease availability non-toxicity. The presence abundant hydrophilic functional groups (like carboxyl hydroxyl) on surface or derivatives makes these materials promising candidates preparation with appealing structures characteristics, leading to growing research in water treatment biomedical fields. These two are typically blended together improve hydrogels' desired qualities (mechanical strength, adsorption properties, cellulose/alginate yield). So, keeping view extensive applicability, present review article, recent advances development cellulose/nanocellulose-alginate-based relevance (adsorption dyes, heavy metals, etc.) field (wound healing, tissue engineering, drug delivery) has reviewed. Further, impact other inorganic/organic additives properties contaminants adsorption, delivery, etc., also studied. Moreover, current difficulties future prospects nanocellulose-alginate-based regarding purification applications discussed at end.

Язык: Английский

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A Review of Functional Hydrogels for Flexible Chemical Sensors

Advanced Sensor Research, Год журнала: 2023, Номер 3(3)

Опубликована: Май 3, 2023

Abstract Hydrogels have drawn considerable attention in the field of flexible chemical sensors due to their unique 3D structure, high permeability, ion‐conductivity, and tissue‐like mechanical properties. These structures properties allow them be functionalized into diverse sensing components respond signals complex environments. Herein, an overview functional hydrogel‐based is provided. First, representative hydrogel materials are introduced operating principles for discussed. Then, state‐of‐the‐art applications highlighted including gas sensors, humidity pH glucose wound monitoring, others. Finally, major challenges opportunities this

Язык: Английский

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Preparation of alginate coated Pt nanoparticle for radiosensitization of breast cancer tumor

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 233, С. 123273 - 123273

Опубликована: Янв. 13, 2023

Язык: Английский

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Hydrogel-assisted microfluidic spinning of stretchable fibers via fluidic and interfacial self-adaptations

Science Advances, Год журнала: 2023, Номер 9(42)

Опубликована: Окт. 20, 2023

Stretchable polymeric fibers have enormous potential, but their production requires rigorous environmental controls and considerable resource consumption. It's also challenging for elastic polymers with high performance poor spinnability, such as silicones like polydimethylsiloxane Ecoflex. We present a hydrogel-assisted microfluidic spinning (HAMS) method to address these challenges by encapsulating prepolymers within arbitrarily long, protective, sacrificable hydrogel fibers. By designing simple apparatuses manipulating the fluidic interfacial self-adaptations of oil/water flows, we successfully produce widely controllable diameter (0.04 3.70 millimeters), notable length, quality (e.g., smooth surface, whole-length uniformity, rounded section), remarkable stretchability (up 1300%) regardless spinnability. Uniquely, this allows an easy, effective, reshaping helical exceptional mechanical compliance. deeply reveal mechanisms in producing demonstrate potential textile components, optoelectronic devices, actuators. The HAMS would be powerful tool mass-producing high-quality stretchable

Язык: Английский

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Microfluidics with redox-responsive hydrogels for on-demand BPA degradation

Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 149542 - 149542

Опубликована: Фев. 20, 2024

An innovative electrochemical microreactor leveraging redox-responsive hydrogels for the targeted removal of organic pollutants has been presented in this study.The centrepiece is a alginate hydrogel cross-linked with iron ions, capable controlling release Fe ions by an external electrical stimulus.The were used to activate persulfate, leading formation reactive sulfate and hydroxyl radicals situ.The system was tested continuous degradation radical oxidation using bisphenol A (BPA) as model system.This unique, responsive feature enables its modulation thus BPA on demand.In operation, efficiency over 94 % achieved, demonstrating enormous potential microfluidic setup environmental remediation various pollutants.By tailoring process conditions, such residence time, even complete achieved.The robust portable design should enable utilization at site contamination.Due efficient control achieved through design, study further delves into adaptability different matrices showcases promising solution increasing global threat water pollution.Thereby, research opens up new strategies niche-oriented pollution management, including model-based approaches.The CFD applied simulate optimize enabling intensification.

Язык: Английский

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Development of a pH-responsive system based on starch and alginate-pectin hydrogels using coaxial 3D food printing

Food Hydrocolloids, Год журнала: 2024, Номер 153, С. 109989 - 109989

Опубликована: Март 11, 2024

Язык: Английский

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Injectable and Multifunctional Hydrogels Based on Poly(N-acryloyl glycinamide) and Alginate Derivatives for Antitumor Drug Delivery

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(12), С. 15322 - 15335

Опубликована: Март 12, 2024

Chemotherapy is a conventional treatment that uses drugs to kill cancer cells; however, it may induce side effects and be incompletely effective, leading the risk of tumor recurrence. To address this issue, we developed novel injectable thermal/near-infrared (NIR)-responsive hydrogels control drug release. The hydrogel formulation was composed biocompatible alginates, poly(N-acryloyl glycinamide) (PNAGA) copolymers with an upper critical solution temperature, NIR-responsive cross-linkers containing coumarin groups, which were gelated through bioorthogonal inverse electron demand Diels–Alder reactions. exhibited quick gelation times (120–800 s) high loading efficiencies (>90%). demonstrated higher percentage release at 37 °C than 25 due enhanced swelling behavior temperature-responsive PNAGA moieties. Upon NIR irradiation, released most entrapped doxorubicin (DOX) (97%) owing cleavage NIR-sensitive ester groups. displayed biocompatibility normal cells, while induced antitumor activity toward cells. DOX/hydrogels treated light inhibited growth in nude mice bearing tumors. In addition, injected emitted red fluorescence upon excitation green wavelength, so delivery degradation vivo could tracked xenograft model.

Язык: Английский

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