Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives

Carbohydrate Polymers, Год журнала: 2023, Номер 324, С. 121537 - 121537

Опубликована: Ноя. 2, 2023

Язык: Английский

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A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications

AAPS PharmSciTech, Год журнала: 2024, Номер 25(4)

Опубликована: Март 21, 2024

Язык: Английский

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3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(3), С. 1449 - 1468

Опубликована: Март 5, 2024

This study introduces a tyrosol-loaded niosome integrated into chitosan–alginate scaffold (Nio-Tyro@CS-AL), employing advanced electrospinning and 3D printing techniques for wound healing applications. The niosomes, measuring 185.40 ± 6.40 nm with polydispersity index of 0.168 0.012, encapsulated tyrosol an efficiency 77.54 1.25%. scaffold's microsized porous structure (600–900 μm) enhances water absorption, promoting cell adhesion, migration, proliferation. Mechanical property assessments revealed the enhanced resilience, niosomes increasing compressive strength, modulus, strain to failure, indicative its suitability healing. Controlled release was demonstrated in vitro, essential therapeutic efficacy. exhibited significant antibacterial activity against Pseudomonas aeruginosa Staphylococcus aureus, substantial biofilm inhibition downregulation bacterial genes (ndvb icab). A assay highlighted notable increase MMP-2 MMP-9 mRNA expression closure area (69.35 2.21%) HFF cells treated Nio-Tyro@CS-AL. In vivo studies mice confirmed biocompatibility, showing no inflammatory response, hypertrophic scarring, or foreign body reaction. Histological evaluations increased fibroblast macrophage activity, re-epithelialization, angiogenesis wounds Nio-Tyro@CS-AL, indicating effective tissue integration repair. Overall, Nio-Tyro@CS-AL presents advancement wound-healing materials, combining properties regeneration, holds promising potential clinical applications management.

Язык: Английский

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Recent advances in biopolymer-based smart hydrogel for wound healing

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105990 - 105990

Опубликована: Сен. 1, 2024

Язык: Английский

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Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Май 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Язык: Английский

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Evaluation of a hydrogel platform for encapsulated multivalent Vibrio antigen delivery to enhance immune responses and disease protection against vibriosis in Asian seabass (Lates calcarifer)

Fish & Shellfish Immunology, Год журнала: 2025, Номер 160, С. 110230 - 110230

Опубликована: Фев. 25, 2025

Язык: Английский

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Zinc‐Directed Coordination Network Hydrogels for A20‐Mediated Inflammation Modulation and Enhanced Axonal Regeneration in Spinal Cord Injury

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Abstract Remodeling the adaptive microenvironment with biomaterials presents a promising avenue for addressing chronic inflammation that contributes to spinal cord injury (SCI) repair. Hydrogels have been widely employed enhance tissue regeneration following SCI. Additionally, zinc (Zn) ions are effective in immune modulation central nervous system. However, significant challenges remain preparing hydrogels combining bioactive Zn 2+ biological functionality traumatic SCI In this study, self‐healing hydrogel composed of an alginate network based on dynamic /bisphosphonate (BP) cross–linking, and silk fibroin interpenetrating polymer is reported. It observed neurite outgrowth promoted by shows dependency concentration. Moreover, ‐releasing enhances neuronal axon growth influences neural stem cell proliferation differentiation. addition, regulates microglial fate upregulating anti‐inflammatory signaling molecule A20 through inhibition NF‐κB pathway. Therefore, effectively improves response while promoting functional recovery, including motor, sensory, bladder function completely transected These results indicate /BP‐based holds potential treatment.

Язык: Английский

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Preparation and Characterization of a Novel High-Stability Gel Foam with Sodium Alginate and Aluminum Ions for Inhibiting Coal Spontaneous Combustion

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136495 - 136495

Опубликована: Фев. 1, 2025

Язык: Английский

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Continuous flow catalytic water remediation using Pd and Pd-Pt nanoplates-functionalized alginate/PVA hydrogels

Journal of Water Process Engineering, Год журнала: 2025, Номер 71, С. 107427 - 107427

Опубликована: Март 1, 2025

Язык: Английский

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Biopolymer aerogels: Structural and functional tailoring of starch/sodium alginate networks

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142774 - 142774

Опубликована: Апрель 1, 2025

Язык: Английский

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