Lecture notes on data engineering and communications technologies, Год журнала: 2025, Номер unknown, С. 699 - 709
Опубликована: Янв. 1, 2025
Язык: Английский
Natural Product Reports, Год журнала: 2023, Номер 40(2), С. 275 - 325
Опубликована: Янв. 1, 2023
A comprehensive review of 1425 new MNPs including a novel cyanobacterial cyclodepsipeptide, gatorbulin-1, that targets 7th tubulin binding site.
Язык: Английский
Процитировано
192
Microbiology Research, Год журнала: 2022, Номер 13(3), С. 418 - 465
Опубликована: Июль 1, 2022
There is a real consensus that new antibiotics are urgently needed and the best chance for combating antibiotic resistance. The phylum Actinobacteria one of main producers antibiotics, with recent paradigm shift whereby rare actinomycetes have been increasingly targeted as source secondary metabolites discovery antibiotics. However, this review shows genus Streptomyces still largest current producer innovative metabolites. Between January 2015 December 2020, significantly high number novel spp. isolated from different environments, including extreme symbionts, terrestrial soils, sediments also marine mainly invertebrates sediments. This highlights 135 species during 6-year period 108 environment 27 sources. A brief summary pre-treatment methods used successful isolation some discussed, well biological activities total 279 recorded 121 which exhibit diverse activity. greatest originated terrestrial-sourced
Язык: Английский
Процитировано
121
Natural Product Reports, Год журнала: 2024, Номер 41(2), С. 162 - 207
Опубликована: Янв. 1, 2024
A comprehensive review of 1411 new MNPs and their structural diversity analysis including the cyanobacterial metabolite lezoside.
Язык: Английский
Процитировано
73
Marine Drugs, Год журнала: 2023, Номер 21(5), С. 308 - 308
Опубликована: Май 19, 2023
Natural Products (NP) are essential for the discovery of novel drugs and products numerous biotechnological applications. The NP process is expensive time-consuming, having as major hurdles dereplication (early identification known compounds) structure elucidation, particularly determination absolute configuration metabolites with stereogenic centers. This review comprehensively focuses on recent technological instrumental advances, highlighting development methods that alleviate these obstacles, paving way accelerating towards Herein, we emphasize most innovative high-throughput tools advancing bioactivity screening, chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, three-dimensional elucidation.
Язык: Английский
Процитировано
65
Natural Product Reports, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
A comprehensive review of 1220 new MNPs including a novel sex inducing pheromone from the diatom Seminavis robusta .
Язык: Английский
Процитировано
3
Biotechnology Advances, Год журнала: 2021, Номер 54, С. 107871 - 107871
Опубликована: Ноя. 19, 2021
Язык: Английский
Процитировано
70
Natural Product Reports, Год журнала: 2022, Номер 39(9), С. 1803 - 1832
Опубликована: Янв. 1, 2022
The article summarizes over 200 cases of misassigned MNPs, identifying major pitfalls still plaguing the structural elucidation small molecules.
Язык: Английский
Процитировано
48
Microbiome, Год журнала: 2023, Номер 11(1)
Опубликована: Июнь 28, 2023
Abstract Background Marine prokaryotes are a rich source of novel bioactive secondary metabolites for drug discovery. Recent genome mining studies have revealed their great potential to bio-synthesize metabolites. However, the exact biosynthetic chemical space encoded by marine has yet be systematically evaluated. Results We first investigated metabolic analyzing diversity and novelty gene clusters (BGCs) in 7541 prokaryotic genomes from cultivated single cells, along with 26,363 newly assembled medium-to-high-quality environmental samples. To quantitatively evaluate unexplored prokaryotes, clustering thresholds constructing cluster molecular networks were optimized reach similar level similarity between family (GCF)-encoded (MF) scaffolds using MIBiG database. The global analysis demonstrated that predicted 70,011 BGCs organized into 24,536 mostly new (99.5%) GCFs, while reported natural products only classified 778 MFs at thresholds. number MF is 3.2% GCF-encoded scaffolds, suggesting least 96.8% untapped. was illustrated 88 antimicrobial peptides ribosomally synthesized post-translationally modified peptide BGCs. Furthermore, sea-water-derived Aquimarina strain selected illustrate diverse through untargeted metabolomics genomics approaches, which identified pathways group polyketides two known compounds (didemnilactone B macrolactin A 15-ketone). Conclusions present bioinformatics cheminformatics analyses highlight promising explore provide valuable knowledge targeted discovery biosynthesis products.
Язык: Английский
Процитировано
30
Marine Life Science & Technology, Год журнала: 2023, Номер 5(1), С. 85 - 93
Опубликована: Янв. 20, 2023
Further insights on the secondary metabolites of a soft coral-derived fungus Aspergillus versicolor under guidance MS/MS-based molecular networking led to isolation seven known cycloheptapeptides, namely, asperversiamides A-C (1-3) and asperheptatides A-D (4-7) an unusual pyrroloindoline-containing new cycloheptapeptide, asperpyrroindotide A (8). The structure 8 was elucidated by comprehensive spectroscopic data analysis, its absolute configuration determined advanced Marfey's method. semisynthetic transformation 1 into successfully achieved reaction conditions were optimized. Additionally, series derivatives (10-19) asperversiamide (1) semi-synthesized their anti-tubercular activities evaluated against Mycobacterium tuberculosis H37Ra. preliminary structure-activity relationships revealed that serine hydroxy groups tryptophan residue are important activity.The online version contains supplementary material available at 10.1007/s42995-022-00157-8.
Язык: Английский
Процитировано
24
Nano Today, Год журнала: 2025, Номер 61, С. 102651 - 102651
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
2