Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties DOI Open Access
Elisa Brambilla, Silvia Locarno, Salvatore Gallo

и другие.

Polymers, Год журнала: 2022, Номер 14(17), С. 3624 - 3624

Опубликована: Сен. 1, 2022

Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) great potential for periodontal disease treatment, thanks to their ability be liquid at room temperature and become viscous body temperature. However, some problems, related short situ residence time, reduce feasible clinical use. Thus, order improve effective applicability these materials, we studied how P407 thermogels are affected by pH inclusion different hydrophilic polymers, used as excipients increasing gel stiffness. For this scope, a complete chemical-physical characterization synthesized is provided, terms determination sol-gel transition temperature, viscosity erosion degree. The data correlated according statistical multivariate approach Principal Component Analysis mucoadhesion properties also tested Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, formulations able influence release pathway two antibacterial drugs (i.e., chlorhexidine digluconate doxycycline hyclate) largely oral diseases.

Язык: Английский

Strategies for body-conformable electronics DOI Creative Commons
Siyi Liu, Yifan Rao, Hongwoo Jang

и другие.

Matter, Год журнала: 2022, Номер 5(4), С. 1104 - 1136

Опубликована: Апрель 1, 2022

Язык: Английский

Процитировано

189

A review of etching methods of MXene and applications of MXene conductive hydrogels DOI
Can Zhou, Xiaohan Zhao, Yingshuo Xiong

и другие.

European Polymer Journal, Год журнала: 2022, Номер 167, С. 111063 - 111063

Опубликована: Фев. 8, 2022

Язык: Английский

Процитировано

185

Functional Hydrogels for Treatment of Chronic Wounds DOI Creative Commons

Ilayda Firlar,

Mine Altunbek,

Colleen McCarthy

и другие.

Gels, Год журнала: 2022, Номер 8(2), С. 127 - 127

Опубликована: Фев. 17, 2022

Chronic wounds severely affect 1-2% of the population in developed countries. It has been reported that nearly 6.5 million people United States suffer from at least one chronic wound their lifetime. The treatment is critical for maintaining physical and mental well-being patients improving quality life. There are a host methods wounds, including debridement, hyperbaric oxygen therapy, ultrasound, electromagnetic therapies, negative pressure skin grafts, hydrogel dressings. Among these, dressings represent promising viable choice because tunable functional properties, such as biodegradability, adhesivity, antimicrobial, anti-inflammatory, pre-angiogenic bioactivities, can accelerate healing wounds. This review summarizes types phases process, key therapeutic approaches. Hydrogel-based reviewed multifunctional properties advantages Examples commercially available also provided to demonstrate effectiveness over other healing.

Язык: Английский

Процитировано

147

Hydrogels for underwater adhesion: adhesion mechanism, design strategies and applications DOI
Xintao Ma, Xun Zhou, Junjie Ding

и другие.

Journal of Materials Chemistry A, Год журнала: 2022, Номер 10(22), С. 11823 - 11853

Опубликована: Янв. 1, 2022

This review summarizes the adhesion mechanism and design strategies of underwater hydrogels, generalizes their application fields (adhesives, motion monitoring, marine environmental exploration coatings).

Язык: Английский

Процитировано

146

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies DOI
Ilker S. Bayer

Advanced Materials Interfaces, Год журнала: 2022, Номер 9(18)

Опубликована: Май 23, 2022

Abstract Mucoadhesion is an extremely important field of adhesion science and the comprehensive understanding modulation mucoadhesion can lead to lifesaving materials technologies. For instance, deadly cases COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral overproduction mucus, which obstructs airways. Mucin key polymeric compound that known as a family high molecular weight, heavily glycosylated proteins in epithelial tissues. occur many different ways such receptor specific charge interactions, covalent or noncovalent bonds. New mucin‐mimic polymers replicate its beneficial traits prevent biofilm formation biofouling not only biotechnology but also membrane This review addresses latest understandings related mucin's role wet considering physiological conditions shows how this translates into interfacial polymer adhesion. Advances measurement techniques including rheological aspects polymer–mucin adhesive interactions presented. Specific mucoadhesive systems discussed hydrogel mucoadhesion, catechol/dopamine functionalization, nanoparticles. overview may expand current between soft contributes elastocapillary phenomena design applications new membranes, drugs, pharmaceutical devices, lubricated surfaces.

Язык: Английский

Процитировано

88

Injectable multifunctional hyaluronic acid/methylcellulose hydrogels for chronic wounds repairing DOI
Linyu Long, Cheng Hu, Wenqi Liu

и другие.

Carbohydrate Polymers, Год журнала: 2022, Номер 289, С. 119456 - 119456

Опубликована: Апрель 4, 2022

Язык: Английский

Процитировано

74

Carbon Dot‐Based Hydrogels: Preparations, Properties, and Applications DOI
Yijie Wang,

Tingjie Lv,

Keyang Yin

и другие.

Small, Год журнала: 2023, Номер 19(17)

Опубликована: Янв. 29, 2023

Hydrogels have extremely high moisture content, which makes it very soft and excellently biocompatible. They become an important material a wide range of applications in various fields such as biomedicine, bionic smart material, electrochemistry. Carbon dot (CD)-based hydrogels are based on carbon dots (CDs) auxiliary substances, forming gel with comprehensive properties individual components. CDs embedding could not only solve their aggregation-caused quenching (ACQ) effect, but also manipulate the even bring some novel properties, achieving win-win situation. In this review, preparation methods, formation mechanism, CD-based hydrogels, sensing, adsorption, energy storage, catalysis -are summarized. Finally, brief discussion future research directions will be given.

Язык: Английский

Процитировано

70

Gel-based strain/pressure sensors for underwater sensing: Sensing mechanisms, design strategies and applications DOI
Xun Zhou, Xiaohan Zhao, Yanyan Wang

и другие.

Composites Part B Engineering, Год журнала: 2023, Номер 255, С. 110631 - 110631

Опубликована: Фев. 21, 2023

Язык: Английский

Процитировано

70

Enhanced Strength for Double Network Hydrogel Adhesive Through Cohesion‐Adhesion Balance DOI Creative Commons
Rijian Song, Xiaoyu Wang, Melissa Johnson

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Фев. 15, 2024

Abstract Hydrogel adhesives exhibit great potential in various biomedical fields such as tissue sealing and soft robotics. However, the high‐water content defective network structures of these hydrogel result low intrinsic mechanical strength, severely impeding their application. In this study, it is reported that strong adhesive strength can be achieved when a balance established between forces cohesive forces. Based on principle, new double (DN) design created to combine an polyvinyl alcohol (PVA) first with flexible sodium alginate (SA) second network. A delicate cohesion adhesion by adjusting ratio rigid As result, balanced DN exhibits approximately three times higher than non‐balance situation.

Язык: Английский

Процитировано

68

Liquid Metal Patterning and Unique Properties for Next‐Generation Soft Electronics DOI Creative Commons
Minwoo Kim, Hyungjun Lim, Seung Hwan Ko

и другие.

Advanced Science, Год журнала: 2023, Номер 10(6)

Опубликована: Янв. 15, 2023

Room-temperature liquid metal (LM)-based electronics is expected to bring advancements in future soft owing its conductivity, conformability, stretchability, and biocompatibility. However, various difficulties arise when patterning LM because of rheological features such as fluidity surface tension. Numerous attempts are made overcome these difficulties, resulting LM-patterning methods. An appropriate choice method based on comprehensive understanding necessary fully utilize the unique properties. Therefore, authors aim provide thorough knowledge about methods properties for LM-based electronics. First, essential considerations investigated. Then, methods-serial-patterning, parallel-patterning, intermetallic bond-assisted patterning, molding/microfluidic injection-are categorized Finally, perspectives with provided. They include outstanding biocompatibility, permeability, restorability, recyclability. Also, they areas radio frequency electronics, robots, heterogeneous catalyst. devices permeate daily lives if aforementioned analyzed utilized.

Язык: Английский

Процитировано

67