Polymers,
Год журнала:
2022,
Номер
14(17), С. 3624 - 3624
Опубликована: Сен. 1, 2022
Thermogelling
amphiphilic
block
copolymers
have
been
widely
investigated
in
the
development
of
pharmaceutical
drug
carriers.
In
particular,
thermosensitive
gels
based
on
poloxamer
407
(P407)
great
potential
for
periodontal
disease
treatment,
thanks
to
their
ability
be
liquid
at
room
temperature
and
become
viscous
body
temperature.
However,
some
problems,
related
short
situ
residence
time,
reduce
feasible
clinical
use.
Thus,
order
improve
effective
applicability
these
materials,
we
studied
how
P407
thermogels
are
affected
by
pH
inclusion
different
hydrophilic
polymers,
used
as
excipients
increasing
gel
stiffness.
For
this
scope,
a
complete
chemical-physical
characterization
synthesized
is
provided,
terms
determination
sol-gel
transition
temperature,
viscosity
erosion
degree.
The
data
correlated
according
statistical
multivariate
approach
Principal
Component
Analysis
mucoadhesion
properties
also
tested
Tapping
mode-Atomic
Force
Microscopy
(TM-AFM)
imaging.
Finally,
formulations
able
influence
release
pathway
two
antibacterial
drugs
(i.e.,
chlorhexidine
digluconate
doxycycline
hyclate)
largely
oral
diseases.
Chronic
wounds
severely
affect
1-2%
of
the
population
in
developed
countries.
It
has
been
reported
that
nearly
6.5
million
people
United
States
suffer
from
at
least
one
chronic
wound
their
lifetime.
The
treatment
is
critical
for
maintaining
physical
and
mental
well-being
patients
improving
quality
life.
There
are
a
host
methods
wounds,
including
debridement,
hyperbaric
oxygen
therapy,
ultrasound,
electromagnetic
therapies,
negative
pressure
skin
grafts,
hydrogel
dressings.
Among
these,
dressings
represent
promising
viable
choice
because
tunable
functional
properties,
such
as
biodegradability,
adhesivity,
antimicrobial,
anti-inflammatory,
pre-angiogenic
bioactivities,
can
accelerate
healing
wounds.
This
review
summarizes
types
phases
process,
key
therapeutic
approaches.
Hydrogel-based
reviewed
multifunctional
properties
advantages
Examples
commercially
available
also
provided
to
demonstrate
effectiveness
over
other
healing.
Journal of Materials Chemistry A,
Год журнала:
2022,
Номер
10(22), С. 11823 - 11853
Опубликована: Янв. 1, 2022
This
review
summarizes
the
adhesion
mechanism
and
design
strategies
of
underwater
hydrogels,
generalizes
their
application
fields
(adhesives,
motion
monitoring,
marine
environmental
exploration
coatings).
Advanced Materials Interfaces,
Год журнала:
2022,
Номер
9(18)
Опубликована: Май 23, 2022
Abstract
Mucoadhesion
is
an
extremely
important
field
of
adhesion
science
and
the
comprehensive
understanding
modulation
mucoadhesion
can
lead
to
lifesaving
materials
technologies.
For
instance,
deadly
cases
COVID‐19
(SARS‐CoV‐2)
cytokine
storm
are
associated
with
viral
overproduction
mucus,
which
obstructs
airways.
Mucin
key
polymeric
compound
that
known
as
a
family
high
molecular
weight,
heavily
glycosylated
proteins
in
epithelial
tissues.
occur
many
different
ways
such
receptor
specific
charge
interactions,
covalent
or
noncovalent
bonds.
New
mucin‐mimic
polymers
replicate
its
beneficial
traits
prevent
biofilm
formation
biofouling
not
only
biotechnology
but
also
membrane
This
review
addresses
latest
understandings
related
mucin's
role
wet
considering
physiological
conditions
shows
how
this
translates
into
interfacial
polymer
adhesion.
Advances
measurement
techniques
including
rheological
aspects
polymer–mucin
adhesive
interactions
presented.
Specific
mucoadhesive
systems
discussed
hydrogel
mucoadhesion,
catechol/dopamine
functionalization,
nanoparticles.
overview
may
expand
current
between
soft
contributes
elastocapillary
phenomena
design
applications
new
membranes,
drugs,
pharmaceutical
devices,
lubricated
surfaces.
Hydrogels
have
extremely
high
moisture
content,
which
makes
it
very
soft
and
excellently
biocompatible.
They
become
an
important
material
a
wide
range
of
applications
in
various
fields
such
as
biomedicine,
bionic
smart
material,
electrochemistry.
Carbon
dot
(CD)-based
hydrogels
are
based
on
carbon
dots
(CDs)
auxiliary
substances,
forming
gel
with
comprehensive
properties
individual
components.
CDs
embedding
could
not
only
solve
their
aggregation-caused
quenching
(ACQ)
effect,
but
also
manipulate
the
even
bring
some
novel
properties,
achieving
win-win
situation.
In
this
review,
preparation
methods,
formation
mechanism,
CD-based
hydrogels,
sensing,
adsorption,
energy
storage,
catalysis
-are
summarized.
Finally,
brief
discussion
future
research
directions
will
be
given.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Фев. 15, 2024
Abstract
Hydrogel
adhesives
exhibit
great
potential
in
various
biomedical
fields
such
as
tissue
sealing
and
soft
robotics.
However,
the
high‐water
content
defective
network
structures
of
these
hydrogel
result
low
intrinsic
mechanical
strength,
severely
impeding
their
application.
In
this
study,
it
is
reported
that
strong
adhesive
strength
can
be
achieved
when
a
balance
established
between
forces
cohesive
forces.
Based
on
principle,
new
double
(DN)
design
created
to
combine
an
polyvinyl
alcohol
(PVA)
first
with
flexible
sodium
alginate
(SA)
second
network.
A
delicate
cohesion
adhesion
by
adjusting
ratio
rigid
As
result,
balanced
DN
exhibits
approximately
three
times
higher
than
non‐balance
situation.
Room-temperature
liquid
metal
(LM)-based
electronics
is
expected
to
bring
advancements
in
future
soft
owing
its
conductivity,
conformability,
stretchability,
and
biocompatibility.
However,
various
difficulties
arise
when
patterning
LM
because
of
rheological
features
such
as
fluidity
surface
tension.
Numerous
attempts
are
made
overcome
these
difficulties,
resulting
LM-patterning
methods.
An
appropriate
choice
method
based
on
comprehensive
understanding
necessary
fully
utilize
the
unique
properties.
Therefore,
authors
aim
provide
thorough
knowledge
about
methods
properties
for
LM-based
electronics.
First,
essential
considerations
investigated.
Then,
methods-serial-patterning,
parallel-patterning,
intermetallic
bond-assisted
patterning,
molding/microfluidic
injection-are
categorized
Finally,
perspectives
with
provided.
They
include
outstanding
biocompatibility,
permeability,
restorability,
recyclability.
Also,
they
areas
radio
frequency
electronics,
robots,
heterogeneous
catalyst.
devices
permeate
daily
lives
if
aforementioned
analyzed
utilized.
