The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(9), С. 5321 - 5328
Опубликована: Апрель 10, 2023
Electrochemical
oxidation
of
alkene
difunctionalization
with
simultaneous
construction
C-Se
and
C-S
bonds
is
reported.
The
products
β-selenylethyl
dithiocarbamates
are
obtained
CS2,
amines,
alkenes,
diphenyl
diselenides
in
the
absence
any
oxidant
or
metal.
Furthermore,
transformation
compatible
various
groups.
In
preliminary
mechanism
studies,
we
propose
three
possible
pathways.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(11), С. 2830 - 2848
Опубликована: Янв. 1, 2023
Recent
advances
in
the
electrochemical
generation
of
1,3-dicarbonyl
radicals
from
C–H
bonds
and
their
mechanistic
insights
synthetic
applications
have
been
summarized.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(49)
Опубликована: Авг. 22, 2023
Abstract
Much
progress
has
been
made
in
the
development
of
methods
to
both
create
compounds
that
contain
C−F
bonds
and
functionalize
bonds.
As
such,
are
becoming
common
versatile
synthetic
functional
handles.
This
review
summarizes
advantages
defluorinative
functionalization
reactions
for
small
molecule
synthesis.
The
coverage
is
organized
by
type
carbon
framework
fluorine
attached
mono‐
polyfluorinated
motifs.
main
challenges,
opportunities
advances
discussed
each
class
organofluorine.
Most
text
focuses
on
case
studies
illustrate
how
defluorofunctionalization
can
improve
routes
targets
or
properties
enable
unique
mechanisms
reactions.
broader
goal
showcase
incorporating
exploiting
design
routes,
improvement
specific
advent
new
methods.
Green Chemistry,
Год журнала:
2023,
Номер
25(9), С. 3543 - 3548
Опубликована: Янв. 1, 2023
An
electrochemical
electrophilic
bromination/spirocyclization
of
N
-benzyl-acrylamides
to
brominated
2-azaspiro[4.5]decanes
with
2-bromoethan-1-ol
as
the
brominating
reagent
has
been
developed.
Chemical Communications,
Год журнала:
2024,
Номер
60(42), С. 5502 - 5505
Опубликована: Янв. 1, 2024
An
organophotoelectrocatalytic
method
for
the
C(sp
2
)–H
alkylation
of
heteroarenes
with
unactivated
3
compounds
via
dehydrogenation
cross-coupling
was
developed.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(16), С. 1913 - 1928
Опубликована: Апрель 24, 2024
Comprehensive
Summary
Organic
fluorine
compounds
are
ubiquitous
and
pivotally
important
organic
molecules,
yet
their
activation
transformation
have
long
been
a
formidable
challenge
due
to
the
high
energy
low
reactivity
of
C—F
bonds.
electrosynthesis,
an
environmentally
benign
synthetic
method
in
chemistry,
enables
myriad
chemical
transformations
without
need
for
external
redox
reagents.
In
recent
years,
electrochemistry
has
emerged
as
powerful
tool
achieving
bonds
fluorine‐containing
compounds.
This
review
aims
succinctly
recapitulate
latest
advancements
electrochemical
defluorinative
delve
into
reaction
design,
mechanistic
insights,
developmental
prospects
these
methods.
Key
Scientists
1959,
Lund
was
first
pioneer
electroreduction
CF
3
CH
group.
Electrochemistry
lately
provided
new
opportunities
efficient
conversion
fluorides.
2020,
Zhou
coworkers
discovered
carboxylation
α‐CF
alkenes.
Lambert
colleagues
reported
electrophotocatalytic
amination
aryl
Electrochemical
hydrodefluorination
trifluoromethylketones
developed
by
Lennox
2021.
same
year,
Wang
Guo
disclosed
radical
alkylation
alkenes
with
Katritzky
salts
alkyl
precursors.
Subsequently,
Wu
Liao
described
transition‐metal‐free,
site‐selective
arylation
polyfluoroarenes
(het)arenes
using
paired
electrophotocatalysis.
2023,
numerous
efforts
were
made
achieve
bond
activation.
Xia
organoboron‐controlled
chemoselective
sequential
(deutero)hydrodefluorination
trifluoroacetamides.
Chemical Science,
Год журнала:
2024,
Номер
15(8), С. 2712 - 2724
Опубликована: Янв. 1, 2024
Frustrated
Lewis
pair
(FLP)
bond
activation
chemistry
has
greatly
developed
over
the
last
two
decades
since
seminal
report
of
metal-free
reversible
hydrogen
activation.
Recently,
FLP
systems
have
been
utilized
to
allow
monoselective
C-F
(at
equivalent
sites)
in
polyfluoroalkanes.
The
problem
'over-defluorination'
functionalization
polyfluoroalkanes
(where
multiple
fluoro-positions
are
uncontrollably
functionalized)
a
long-standing
chemical
fluorocarbon
for
80
years.
mediated
is
complementary
other
solutions
address
and
offers
several
advantages
unique
opportunities.
This
perspective
highlights
some
these
opportunities
places
development
into
context
wider
effort
overcome
'over-defluorination'.
Organic Chemistry Frontiers,
Год журнала:
2022,
Номер
9(13), С. 3598 - 3623
Опубликована: Янв. 1, 2022
The
combination
of
visible
light
photoredox
catalysis
with
direct
difluoromethylation
has
allowed
the
synthesis
a
large
choice
CF
2
H-containing
value-added
molecules
under
very
mild
reaction
conditions.
Chemistry - An Asian Journal,
Год журнала:
2021,
Номер
17(1)
Опубликована: Ноя. 26, 2021
With
eco-friendly
and
sustainable
CO2
-derived
dimethyl
carbonate
as
the
sole
solvent,
visible-light-induced
cascade
radical
reactions
have
been
established
a
green
efficient
tool
for
constructing
various
CHF2
/CClF2
/CBrF2
-substituted
ring-fused
quinazolinones.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(14), С. 3585 - 3590
Опубликована: Янв. 1, 2023
An
organophotoelectrochemical
approach
for
silylation
cyclization
of
CF3-substituted
N
-arylacrylamides
with
organosilanes
under
transition-metal-free
and
oxidant-free
conditions
has
been
developed.
