Polycyclic aromatic compounds,
Год журнала:
2023,
Номер
unknown, С. 1 - 19
Опубликована: Ноя. 7, 2023
Research
on
synthetic
methods
for
the
preparation
of
oxazoles
is
an
important
issue
among
chemists
because
oxazole
derivatives
are
structural
subunits
various
natural
active
products
and
valuable
pharmaceutical
precursors.
In
this
research
work,
we
constructed
CuBr
supported
surface
magnetic
Fe3O4
nanoparticles
modified
with
6-(aminomethyl)nicotinic
acid
[Fe3O4@AMNA-CuBr
nanocomposite]
evaluated
its
catalytic
activity
highly
substituted
through
one-pot
three-component
reactions
diphenylacetylene
aryl
nitriles
water
in
PEG
as
solvent.
The
results
shown
that
Fe3O4@AMNA-CuBr
catalyst
was
used
8
times
without
significant
decrease
activity.
XRD
TEM
analysis
confirmed
structure
morphology
did
not
change
after
runs.
Organic Letters,
Год журнала:
2023,
Номер
25(38), С. 7014 - 7019
Опубликована: Сен. 18, 2023
Organoelectrophotocatalytic
generation
of
acyl
radicals
from
formamides
and
aldehydes
to
synthesize
acylated
3-CF3-2-oxindoles
has
been
developed.
This
protocol
features
a
monocatalytic
system
using
9,10-phenanthrenequinone
(PQ)
both
as
catalyst
hydrogen
atom
transfer
(HAT)
reagent,
which
avoids
the
use
an
external
HAT
metal
oxidant.
A
variety
have
obtained
in
satisfactory
yields
CF3-substituted
N-arylacrylamides
via
tandem
radical
cyclization.
Chemical Communications,
Год журнала:
2024,
Номер
60(42), С. 5502 - 5505
Опубликована: Янв. 1, 2024
An
organophotoelectrocatalytic
method
for
the
C(sp
2
)–H
alkylation
of
heteroarenes
with
unactivated
3
compounds
via
dehydrogenation
cross-coupling
was
developed.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(16), С. 1913 - 1928
Опубликована: Апрель 24, 2024
Comprehensive
Summary
Organic
fluorine
compounds
are
ubiquitous
and
pivotally
important
organic
molecules,
yet
their
activation
transformation
have
long
been
a
formidable
challenge
due
to
the
high
energy
low
reactivity
of
C—F
bonds.
electrosynthesis,
an
environmentally
benign
synthetic
method
in
chemistry,
enables
myriad
chemical
transformations
without
need
for
external
redox
reagents.
In
recent
years,
electrochemistry
has
emerged
as
powerful
tool
achieving
bonds
fluorine‐containing
compounds.
This
review
aims
succinctly
recapitulate
latest
advancements
electrochemical
defluorinative
delve
into
reaction
design,
mechanistic
insights,
developmental
prospects
these
methods.
Key
Scientists
1959,
Lund
was
first
pioneer
electroreduction
CF
3
CH
group.
Electrochemistry
lately
provided
new
opportunities
efficient
conversion
fluorides.
2020,
Zhou
coworkers
discovered
carboxylation
α‐CF
alkenes.
Lambert
colleagues
reported
electrophotocatalytic
amination
aryl
Electrochemical
hydrodefluorination
trifluoromethylketones
developed
by
Lennox
2021.
same
year,
Wang
Guo
disclosed
radical
alkylation
alkenes
with
Katritzky
salts
alkyl
precursors.
Subsequently,
Wu
Liao
described
transition‐metal‐free,
site‐selective
arylation
polyfluoroarenes
(het)arenes
using
paired
electrophotocatalysis.
2023,
numerous
efforts
were
made
achieve
bond
activation.
Xia
organoboron‐controlled
chemoselective
sequential
(deutero)hydrodefluorination
trifluoroacetamides.
Chinese Journal of Chemistry,
Год журнала:
2023,
Номер
41(22), С. 2963 - 2968
Опубликована: Июнь 24, 2023
Comprehensive
Summary
A
photoelectrochemical
approach
for
the
C—H
silylation
of
heteroarenes
through
dehydrogenation
cross‐coupling
with
H
2
evolution
has
been
developed.
The
depends
on
hydrogen
atom
transfer
(HAT)
from
silanes
to
Cl‐radical
generated
light‐induced
homolytic
cleavage
Cl
,
in
which
was
produced
by
electrochemical
oxidation
chloride.
large
number
silylated
heterocyclic
molecules
are
rapidly
constructed
satisfactory
yields
without
relying
oxidants
and
metal
reagents.
Saudi Pharmaceutical Journal,
Год журнала:
2023,
Номер
31(12), С. 101874 - 101874
Опубликована: Ноя. 22, 2023
Novel
α-amylase
inhibitors
play
a
crucial
role
in
managing
diabetes
and
obesity,
contributing
to
improved
public
health
by
addressing
these
challenging
prevalent
conditions.
Moreover,
the
synthesis
of
anti-oxidant
agents
is
essential
due
their
potential
combating
oxidative
stress-related
diseases
promoting
overall
health.Synthesis
thoisemicarbazone
derivatives
2,4-dichlorophenyl
acetic
acid
screened
them
for
biological
activities.Thiosemicarbazone
(4-13)
were
synthesized
refluxing
with
sulfuric
ethanol
get
ester
(2),
which
was
further
refluxed
thiosemicarbazide
compound
(3).
Finally,
different
aromatic
aldehydes
(3)
catalytic
amount
obtained
final
products
(4-13).
Using
modern
spectroscopic
techniques
including
HR-ESI-MS,
13C-,
1H
NMR,
structures
created
confirmed.The
showed
excellent
good
inhibitory
activity
range
IC50
values
4.95
±
0.44
69.71
0.05
µM
against
enzyme
when
compared
standard
drug
acarbose
(IC50
=
21.55
1.31
µM).
In
case
iron
chelating
activity,
potent
better
than
EDTA
66.43
1.07
µM)
22.43
2.09
61.21
2.83
µM.
However,
also
show
28.30
1.17
64.66
2.43
hydroxyl
radical
scavenging
vitamin
C
60.51
1.02
DFT
used
calculate
reactivity
factors
ionization
potential,
electronegativity,
electron
affinity,
chemical
softness,
hardness
calculated
using
frontier
molecular
orbital
(FMO)
computations.
The
docking
studies
carried
out
AutoDock
Vina
understand
binding
affinities
active
sites
protein.
Green Chemistry,
Год журнала:
2024,
Номер
26(7), С. 4199 - 4208
Опубликована: Янв. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2352 - 2362
Опубликована: Апрель 5, 2024
Abstract
While
the
emergence
of
electrophotochemistry
provides
opportunities,
such
a
chemistry
at
this
stage
suffers
from
limited
reaction
types
and
high
photocatalyst
loadings.
A
self‐catalyzed
electrophotosynthesis
as
well
one
with
low
loading
is
presented.
These
external‐oxidant‐free
cyclizations
are
enabling
applicable
to
range
activated
alkenes,
affording
diverse
array
thiocyanato
heterocycles
including
4‐pyrrolin‐2‐ones,
isoquinoline‐1,3‐diones,
indolo[2,1‐
]isoquinolin‐6(5
H
)‐ones,
benzoimidazo[2,1‐
)‐ones
indolin‐2‐ones,
protocols
amenable
late‐stage
diversification
complex
molecular
architectures
gram‐scale
syntheses.
Sunlight
could
serve
light
source,
be
conducted
in
an
all‐solar‐driven
mode
using
commercially
available
photovoltaic
panel
produce
electricity.
Chemical Reviews,
Год журнала:
2024,
Номер
124(21), С. 12264 - 12304
Опубликована: Окт. 23, 2024
Electrocatalysis
and
photocatalysis
have
been
the
focus
of
extensive
research
efforts
in
organic
synthesis
recent
decades,
these
powerful
strategies
provided
a
wealth
new
methods
to
construct
complex
molecules.
Despite
intense
efforts,
only
recently
has
there
significant
on
combined
use
two
modalities.
Nevertheless,
past
five
years
witnessed
rapidly
growing
interest
area
electrophotocatalysis.
This
hybrid
strategy
capitalizes
enormous
benefits
using
photons
as
reagents
while
also
employing
an
electric
potential
convenient
tunable
source
or
sink
electrons.
Research
this
topic
led
number
for
C-H
functionalization,
reductive
cross-coupling,
olefin
addition
among
others.
field
seen
broad
range
catalyst
types,
including
both
metal
organocatalysts.
Of
particular
note
work
with
open-shell
photocatalysts,
which
tend
comparatively
large
redox
potentials.
Electrochemistry
provides
means
generate
such
species,
making
electrophotocatalysis
particularly
amenable
intriguing
class
catalyst.
review
surveys
applied
synthesis,
organized
broadly
into
oxidative,
reductive,
neutral
transformations.
