Chinese Journal of Organic Chemistry,
Год журнала:
2022,
Номер
42(4), С. 1123 - 1123
Опубликована: Янв. 1, 2022
The
N-deacylation
of
amides
under
mild
conditions
is
highly
desirable
in
organic
synthesis,
but
it
remains
challenging
due
to
the
chemically
robust
nature
amide
bond.A
general
solution
with
NH3•H2O
and
scalable
(10
mmol)
was
developed.A
range
drugs
drug
derivatives
including
indomethacin,
N-acetyl
melatonin
carprofen
could
be
deacylated
release
free
amines
excellent
yields.The
good
functional
group
compatibility,
combined
operational
simplicity,
yield
cost
effectiveness
all
reagents,
makes
this
protocol
a
prime
candidate
for
amide.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(6), С. 871 - 876
Опубликована: Фев. 28, 2023
An
aerobic
Mn(III)-catalyzed
one-pot
three-component
synthesis
of
5-cyano-pyrazolo[1,5-a]pyrimidines
has
been
described.
The
synergistic
combination
Strecker
reaction
and
oxidatively-induced
6π-azacyclization
is
the
key
to
success
this
multicomponent
synthesis.
Differing
from
previous
reports
relied
on
toxic
cyanating
agents
or
multistep
synthesis,
mechanistically
distinct
protocol
serves
as
a
step-economic,
regioselective
functionally
tolerant
strategy
obtain
5-cyano-pyrazolo[1,5-a]pyrimidines.
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authors
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reviewed
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delivery,
but
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copy-edited
typeset.
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(other
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files)
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addressed
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note:
publisher
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any
Any
queries
content)
directed
corresponding
author
article.
Organic Chemistry Frontiers,
Год журнала:
2022,
Номер
9(5), С. 1403 - 1409
Опубликована: Янв. 1, 2022
An
I
2
-mediated
[3
+
2]
annulation
to
access
fused
imidazoles
from
methyl-azaarenes
and
alkyl
2-isocyanoacetates
was
developed.
This
method
can
be
used
for
the
structural
modification
of
natural
products,
gram
scale
reactions
further
transformations.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(11)
Опубликована: Окт. 2, 2023
Abstract
Biocatalysis
has
been
an
emerging
field
in
organic
synthetic
chemistry
recent
years
and
significantly
expanded
the
application
of
enzymes.
Further,
concept
enzymatic
promiscuity,
where
enzyme
catalyzes
reactions
beyond
its
natural
function,
recognized
as
a
valuable
phenomenon
that
can
enhance
versatility
biocatalyst.
Recent
advancements
synthesis,
driven
by
demand
for
more
efficient
environmentally
friendly
processes,
have
led
to
development
enzyme‐catalyzed
multicomponent
such
Biginelli
reaction,
Hantzsch
Mannich,
Ugi,
etc.
synthesis
N
‐Heterocyclic
compounds.
While
number
enzymes
played
important
role
this
context,
lipase
is
still
indispensable
due
low
cost,
easy
availability,
higher
solvent
tolerance.
In
particular,
immobilization
on
various
supports
enhances
stability,
reusability,
efficiency
catalyzing
transformation,
which
expands
traditional
biocatalytic
methods.
review,
we
mainly
compiled
findings
highlight
applications
lipases
manufacturing
several
types
‐containing
heterocyclic
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Июнь 20, 2022
N
-heterocycles
are
key
structural
units
in
many
drugs,
biologically
interesting
molecules
and
functional
materials.
To
avoid
the
residues
of
metal
catalysts,
construction
under
metal-free
conditions
has
attracted
much
research
attention
academia
industry.
Among
them,
intramolecular
electrochemical
C-H
aminations
arguably
constitute
environmentally
friendly
methodologies
for
-heterocycles,
mainly
due
to
direct
use
clean
electricity
as
redox
agents.
With
recent
renaissance
organic
electrosynthesis,
have
undergone
progress
years.
In
this
article,
we
would
like
summarize
advances
field
since
2019.
The
emphasis
is
placed
on
reaction
design
mechanistic
insight.
challenges
future
developments
also
discussed.
Molecules,
Год журнала:
2023,
Номер
28(3), С. 1397 - 1397
Опубликована: Фев. 1, 2023
The
first
example
of
paired
electrolysis-enabled
cyanation
diaryl
diselenides,
with
KSCN
as
the
green
cyanating
agent,
has
been
developed.
A
broad
range
aryl
selenocyanates
can
be
efficiently
synthesized
under
chemical-oxidant-
and
additive-free,
energy-saving
mild
conditions.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(4), С. 1009 - 1014
Опубликована: Янв. 1, 2023
The
reaction
of
arylaldehydes
and
arylamines
with
nontoxic
NH
4
SCN
in
the
presence
TBHP
led
to
a
divergent
Strecker
synthesis
aminonitriles
iminonitriles.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(17), С. 12244 - 12250
Опубликована: Авг. 22, 2023
A
copper-catalyzed
reaction
of
pyridinium
salts
and
trimethylsilyl
cyanide
(TMSCN)
in
the
presence
diethyl
phosphite
is
developed.
This
reaction,
which
allows
single-step
construction
biologically
important
2-cyanoimidazo[1,2-a]pyridine
from
readily
available
starting
materials,
realized
for
first
time
feasible
at
gram
scale.
The
scope
protocol
demonstrated
with
27
examples.
consecutive
double
cyanation
cyclization
can
be
achieved
this
one-pot
process.
TMSCN
plays
a
dual
role
not
only
as
"CN"
source
but
also
coupling
partner
imidazo[1,2-a]pyridines.
