The
methodological
advancements
in
surface-enhanced
Raman
scattering
(SERS)
technique
with
nanoscale
materials
based
on
noble
metals,
Au,
Ag,
and
their
bimetallic
alloy
Au-Ag,
has
enabled
the
highly
efficient
sensing
of
chemical
biological
molecules
at
very
low
concentration
values.
By
employing
innovative
various
type
Ag
nanoparticles
especially,
high
efficiency
Au@Ag
nanomaterials
as
substrate
SERS
biosensors
have
revolutionized
detection
components
including;
proteins,
antigens
antibodies
complex,
circulating
tumor
cells,
DNA,
RNA
(miRNA),
etc.
This
review
is
about
SERS-based
Au/Ag
enhanced
activity
by
focusing
different
factors
related
to
them.
emphasis
this
research
describe
recent
developments
field
conceptual
behind
Furthermore,
article
we
apex
understanding
impact
variation
basic
features
like
effects
size,
shape
varying
lengths,
thickness
core-shell
influence
large-scale
magnitude
morphology.
Moreover,
detailed
information
applications
these
importantly
receptor
binding
domain
(RBD)
protein
COVID-19
provided.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 6, 2023
Abstract
Surface-Enhanced
Raman
Scattering
(SERS)
technology,
as
a
powerful
tool
to
identify
molecular
species
by
collecting
spectral
signals
at
the
single-molecule
level,
has
achieved
substantial
progresses
in
fields
of
environmental
science,
medical
diagnosis,
food
safety,
and
biological
analysis.
As
deepening
research
is
delved
into
SERS
sensing,
more
high-performance
or
multifunctional
substrate
materials
emerge,
which
are
expected
push
sensing
application
fields.
Especially
field
analysis,
intrinsic
extrinsic
schemes
have
been
widely
used
explored
due
their
fast,
sensitive
reliable
advantages.
Herein,
recent
developments
substrates
applications
biomolecular
detection
(SARS-CoV-2
virus,
tumor
etc.),
imaging
pesticide
summarized.
The
concepts
(including
its
basic
theory
mechanism)
important
strategies
(extending
from
nanomaterials
with
tunable
shapes
nanostructures
surface
bio-functionalization
modifying
affinity
groups
specific
biomolecules)
for
improving
biosensing
performance
comprehensively
discussed.
For
data
analysis
identification,
machine
learning
methods
software
acquisition
sources
diagnosing
discussed
detail.
In
conclusion,
challenges
perspectives
future
presented.
Biosensors,
Год журнала:
2021,
Номер
11(12), С. 512 - 512
Опубликована: Дек. 13, 2021
The
growing
interest
in
the
development
of
new
platforms
for
application
Raman
spectroscopy
techniques
biosensor
technologies
is
driven
by
potential
these
identifying
chemical
compounds,
as
well
structural
and
functional
features
biomolecules.
effect
scattering
a
result
inelastic
light
processes,
which
lead
to
emission
scattered
with
different
frequency
associated
molecular
vibrations
identified
molecule.
Spontaneous
usually
weak,
resulting
complexities
separation
weak
inelastically
intense
Rayleigh
scattering.
These
limitations
have
led
various
enhancing
scattering,
including
resonance
(RRS)
nonlinear
(coherent
anti-Stokes
stimulated
spectroscopy).
Furthermore,
discovery
phenomenon
enhanced
near
metallic
nanostructures
gave
impetus
surface-enhanced
(SERS)
its
combination
spectroscopic
techniques.
resonant
optical
effects
metal
substrates
or
nanoparticles
can
be
used
increase
speed,
spatial
resolution,
signal
amplification
spectroscopy,
making
promising
analysis
characterization
biological
samples.
This
review
provides
main
provisions
listed
advantages
present
when
applied
life
sciences
research.
recent
advances
SERS
SERS-combined
are
summarized,
such
SERRS,
SE-CARS,
SE-SRS
bioimaging
biosensing
molecules,
form
basis
future
applications
technology.
In
addition,
an
overview
given
tools
success
biosensors
based
on
techniques,
achieved
choosing
one
following
approaches:
(i)
fabrication
reproducible
substrate,
(ii)
synthesis
nanotag,
(iii)
implementation
on-site
testing.
The Journal of Physical Chemistry A,
Год журнала:
2022,
Номер
126(47), С. 8781 - 8798
Опубликована: Ноя. 8, 2022
This
Feature
Article
starts
highlighting
some
recent
experimental
and
theoretical
advances
in
the
field
of
IR
Raman
spectroscopy,
giving
a
taste
breadth
dynamics
this
striving
field.
The
local
mode
theory
is
then
reviewed,
showing
how
vibrational
modes
are
derived
from
fundamental
normal
modes.
New
features
introduced
that
add
to
current
efforts:
(i)
unique
measure
bond
strength
based
on
force
constants
ranging
bonding
single
molecules
different
environments
periodic
systems
crystals
(ii)
new
way
interpret
spectra
by
pinpointing
probing
interactions
between
particular
stretching
contributions
All
represents
means
work
around
very
nature
modes,
namely
motions
polyatomic
delocalized.
Three
focus
points
analysis
reported,
demonstrating
extracts
important
information
hidden
spectroscopy
data
supporting
experiments:
metal–ligand
heme
proteins,
such
as
myoglobin
neuroglobin;
disentanglement
DNA
modes;
(iii)
hydrogen
water
clusters
ice.
Finally,
use
other
research
groups
summarized.
Our
vision
future
will
be
routinely
applied
community
serves
an
incubator
for
collaborations
experiment
theory.
Biosensors and Bioelectronics,
Год журнала:
2022,
Номер
202, С. 114008 - 114008
Опубликована: Янв. 20, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
affected
humans
worldwide
for
over
a
year
now.
Although
various
tests
have
been
developed
the
detection
of
SARS-CoV-2,
advanced
sensing
methods
are
required
diagnosis,
screening,
and
surveillance
disease
2019
(COVID-19).
Here,
we
report
surface-enhanced
Raman
scattering
(SERS)-based
immunoassay
involving
an
antibody
pair,
SERS-active
hollow
Au
nanoparticles
(NPs),
magnetic
beads
SARS-CoV-2.
The
selected
pair
against
SARS-CoV-2
antigen,
along
with
beads,
facilitates
accurate
direct
virus.
NPs
exhibit
strong,
reproducible
SERS
signals,
allowing
sensitive
quantitative
This
assay
had
limits
2.56
fg/mL
antigen
3.4
plaque-forming
units/mL
lysates.
Furthermore,
it
facilitated
identification
in
human
nasopharyngeal
aspirates
diagnosis
COVID-19
within
30
min
using
portable
device.
Thus,
this
can
be
potentially
used
prevention
COVID-19.
ACS Applied Nano Materials,
Год журнала:
2022,
Номер
5(10), С. 14051 - 14091
Опубликована: Сен. 23, 2022
The
emergence
of
plasmonic
nanostars
with
their
attractive
properties
and
unique
versatility
has
enabled
a
wide
range
advanced
technologies
critical
to
human
health,
safety,
energy,
environmental
remediation
vast
potential
for
further
exploration.
In
addition
superior
surface-to-volume
ratios
compared
those
other
nanostructures,
arguably
possess
the
largest
numbers
hotspots
intensely
amplified
electric
fields
when
they
are
subjected
suitable
electromagnetic
waves
trigger
localized
surface
plasmon
resonance
(LSPR).
These
outstanding
characteristics
make
ideal
many
applications
that
benefit
from
enhancement
effect
LSPR
and/or
large
area.
Over
past
decade,
an
increasing
number
research
endeavors
been
reported
on
synthesis
application
advance
state-of-the-art
various
existing
technologies.
contributions
pertinent
real-time
image-guided
multifunctional
anticancer
theranostics,
ultrasensitive
on-site
detection
devastating
virus
SARS-CoV-2,
multimodal
multiplexed
brain
imaging,
greatly
enhanced
catalysts
energy
processes,
or
more
efficient
stable
solar
cells.
important
but
familiar
technologies,
have
also
employed
push
technological
frontiers
in
multiple
enable
such
as
maskless
write-on
lithography,
nanosized
field
electron
emitters,
coherent
random
lasers,
neural
activity
modulation,
optically
controlled
electrical
currents.
Despite
great
performance
since
introduction,
nascency
this
class
nanostructures
rise
types
nanostars,
dominance
gold
recent
years,
indicate
there
still
opportunities
study,
exploration,
development.
This
Review
outlines
comprehensive
picture
current
state
nanostar
focus
scientific
applications.
We
hope
will
enlighten
future
collective
develop
effective
incorporate
them
into
mainstream
so
these
stars
can
truly
shine.
Biophysical Reviews,
Год журнала:
2023,
Номер
15(2), С. 199 - 221
Опубликована: Апрель 1, 2023
Abstract
Raman
spectroscopy
offers
the
potential
for
fingerprinting
biological
molecules
at
ultra-low
concentration
and
therefore
has
detection
of
viruses.
Here
we
review
various
techniques
employed
investigation
Different
are
discussed
including
conventional
spectroscopy,
surface-enhanced
tweezer,
tip-enhanced
Spectroscopy,
coherent
anti-Stokes
scattering.
Surface-enhanced
scattering
can
play
an
essential
role
in
viral
by
multiplexing
nanotechnology,
microfluidics,
machine
learning
ensuring
spectral
reproducibility
efficient
workflow
sample
processing
detection.
The
application
these
to
diagnose
SARS-CoV-2
virus
is
also
reviewed.
Graphical
abstract
Nanoscale Advances,
Год журнала:
2023,
Номер
5(8), С. 2132 - 2166
Опубликована: Янв. 1, 2023
NIR-SERS
and
the
concomitant
tailoring
of
detection
setup,
as
well
tuning
shape,
material,
architecture
enhancing
substrates,
allow
for
bioanalytical
studies,
including
cell
through-tissue
measurements.
