Recent advances of Au@Ag core–shell SERS‐based biosensors

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Feb. 1, 2023

The methodological advancements in surface-enhanced Raman scattering (SERS) technique with nanoscale materials based on noble metals, Au, Ag, and their bimetallic alloy Au-Ag, has enabled the highly efficient sensing of chemical biological molecules at very low concentration values. By employing innovative various type Ag nanoparticles especially, high efficiency Au@Ag nanomaterials as substrate SERS biosensors have revolutionized detection components including; proteins, antigens antibodies complex, circulating tumor cells, DNA, RNA (miRNA), etc. This review is about SERS-based Au/Ag enhanced activity by focusing different factors related to them. emphasis this research describe recent developments field conceptual behind Furthermore, article we apex understanding impact variation basic features like effects size, shape varying lengths, thickness core-shell influence large-scale magnitude morphology. Moreover, detailed information applications these importantly receptor binding domain (RBD) protein COVID-19 provided.

Language: Английский

---

Recent development of surface-enhanced Raman scattering for biosensing

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 6, 2023

Abstract Surface-Enhanced Raman Scattering (SERS) technology, as a powerful tool to identify molecular species by collecting spectral signals at the single-molecule level, has achieved substantial progresses in fields of environmental science, medical diagnosis, food safety, and biological analysis. As deepening research is delved into SERS sensing, more high-performance or multifunctional substrate materials emerge, which are expected push sensing application fields. Especially field analysis, intrinsic extrinsic schemes have been widely used explored due their fast, sensitive reliable advantages. Herein, recent developments substrates applications biomolecular detection (SARS-CoV-2 virus, tumor etc.), imaging pesticide summarized. The concepts (including its basic theory mechanism) important strategies (extending from nanomaterials with tunable shapes nanostructures surface bio-functionalization modifying affinity groups specific biomolecules) for improving biosensing performance comprehensively discussed. For data analysis identification, machine learning methods software acquisition sources diagnosing discussed detail. In conclusion, challenges perspectives future presented.

Language: Английский

---

Raman Scattering-Based Biosensing: New Prospects and Opportunities

Biosensors, Journal Year: 2021, Volume and Issue: 11(12), P. 512 - 512

Published: Dec. 13, 2021

The growing interest in the development of new platforms for application Raman spectroscopy techniques biosensor technologies is driven by potential these identifying chemical compounds, as well structural and functional features biomolecules. effect scattering a result inelastic light processes, which lead to emission scattered with different frequency associated molecular vibrations identified molecule. Spontaneous usually weak, resulting complexities separation weak inelastically intense Rayleigh scattering. These limitations have led various enhancing scattering, including resonance (RRS) nonlinear (coherent anti-Stokes stimulated spectroscopy). Furthermore, discovery phenomenon enhanced near metallic nanostructures gave impetus surface-enhanced (SERS) its combination spectroscopic techniques. resonant optical effects metal substrates or nanoparticles can be used increase speed, spatial resolution, signal amplification spectroscopy, making promising analysis characterization biological samples. This review provides main provisions listed advantages present when applied life sciences research. recent advances SERS SERS-combined are summarized, such SERRS, SE-CARS, SE-SRS bioimaging biosensing molecules, form basis future applications technology. In addition, an overview given tools success biosensors based on techniques, achieved choosing one following approaches: (i) fabrication reproducible substrate, (ii) synthesis nanotag, (iii) implementation on-site testing.

Language: Английский

---

The Local Vibrational Mode Theory and Its Place in the Vibrational Spectroscopy Arena

The Journal of Physical Chemistry A, Journal Year: 2022, Volume and Issue: 126(47), P. 8781 - 8798

Published: Nov. 8, 2022

This Feature Article starts highlighting some recent experimental and theoretical advances in the field of IR Raman spectroscopy, giving a taste breadth dynamics this striving field. The local mode theory is then reviewed, showing how vibrational modes are derived from fundamental normal modes. New features introduced that add to current efforts: (i) unique measure bond strength based on force constants ranging bonding single molecules different environments periodic systems crystals (ii) new way interpret spectra by pinpointing probing interactions between particular stretching contributions All represents means work around very nature modes, namely motions polyatomic delocalized. Three focus points analysis reported, demonstrating extracts important information hidden spectroscopy data supporting experiments: metal–ligand heme proteins, such as myoglobin neuroglobin; disentanglement DNA modes; (iii) hydrogen water clusters ice. Finally, use other research groups summarized. Our vision future will be routinely applied community serves an incubator for collaborations experiment theory.

Language: Английский

---

Surface-enhanced Raman scattering-based immunoassay for severe acute respiratory syndrome coronavirus 2

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 202, P. 114008 - 114008

Published: Jan. 20, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected humans worldwide for over a year now. Although various tests have been developed the detection of SARS-CoV-2, advanced sensing methods are required diagnosis, screening, and surveillance disease 2019 (COVID-19). Here, we report surface-enhanced Raman scattering (SERS)-based immunoassay involving an antibody pair, SERS-active hollow Au nanoparticles (NPs), magnetic beads SARS-CoV-2. The selected pair against SARS-CoV-2 antigen, along with beads, facilitates accurate direct virus. NPs exhibit strong, reproducible SERS signals, allowing sensitive quantitative This assay had limits 2.56 fg/mL antigen 3.4 plaque-forming units/mL lysates. Furthermore, it facilitated identification in human nasopharyngeal aspirates diagnosis COVID-19 within 30 min using portable device. Thus, this can be potentially used prevention COVID-19.

Language: Английский

---

High-sensitivity and point-of-care detection of SARS-CoV-2 from nasal and throat swabs by magnetic SERS biosensor

Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 365, P. 131974 - 131974

Published: April 28, 2022

Language: Английский

---

Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 208, P. 114200 - 114200

Published: March 22, 2022

Language: Английский

---

Plasmonic Nanostars: Systematic Review of their Synthesis and Applications

ACS Applied Nano Materials, Journal Year: 2022, Volume and Issue: 5(10), P. 14051 - 14091

Published: Sept. 23, 2022

The emergence of plasmonic nanostars with their attractive properties and unique versatility has enabled a wide range advanced technologies critical to human health, safety, energy, environmental remediation vast potential for further exploration. In addition superior surface-to-volume ratios compared those other nanostructures, arguably possess the largest numbers hotspots intensely amplified electric fields when they are subjected suitable electromagnetic waves trigger localized surface plasmon resonance (LSPR). These outstanding characteristics make ideal many applications that benefit from enhancement effect LSPR and/or large area. Over past decade, an increasing number research endeavors been reported on synthesis application advance state-of-the-art various existing technologies. contributions pertinent real-time image-guided multifunctional anticancer theranostics, ultrasensitive on-site detection devastating virus SARS-CoV-2, multimodal multiplexed brain imaging, greatly enhanced catalysts energy processes, or more efficient stable solar cells. important but familiar technologies, have also employed push technological frontiers in multiple enable such as maskless write-on lithography, nanosized field electron emitters, coherent random lasers, neural activity modulation, optically controlled electrical currents. Despite great performance since introduction, nascency this class nanostructures rise types nanostars, dominance gold recent years, indicate there still opportunities study, exploration, development. This Review outlines comprehensive picture current state nanostar focus scientific applications. We hope will enlighten future collective develop effective incorporate them into mainstream so these stars can truly shine.

Language: Английский

---

Raman spectroscopy for viral diagnostics

Biophysical Reviews, Journal Year: 2023, Volume and Issue: 15(2), P. 199 - 221

Published: April 1, 2023

Abstract Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has detection of viruses. Here we review various techniques employed investigation Different are discussed including conventional spectroscopy, surface-enhanced tweezer, tip-enhanced Spectroscopy, coherent anti-Stokes scattering. Surface-enhanced scattering can play an essential role in viral by multiplexing nanotechnology, microfluidics, machine learning ensuring spectral reproducibility efficient workflow sample processing detection. The application these to diagnose SARS-CoV-2 virus is also reviewed. Graphical abstract

Language: Английский

---

Challenges and opportunities for SERS in the infrared: materials and methods

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(8), P. 2132 - 2166

Published: Jan. 1, 2023

NIR-SERS and the concomitant tailoring of detection setup, as well tuning shape, material, architecture enhancing substrates, allow for bioanalytical studies, including cell through-tissue measurements.

Language: Английский

---