Cancers,
Год журнала:
2024,
Номер
16(12), С. 2171 - 2171
Опубликована: Июнь 7, 2024
Cancer
cells
show
altered
antioxidant
defense
systems,
dysregulated
redox
signaling,
and
increased
generation
of
reactive
oxygen
species
(ROS).
Targeting
cancer
through
ROS-mediated
mechanisms
has
emerged
as
a
significant
therapeutic
strategy
due
to
its
implications
in
progression,
survival,
resistance.
Extensive
research
focused
on
selective
H2O2
for
cell
killing
by
employing
various
strategies
such
metal-based
prodrugs,
photodynamic
therapy,
enzyme-based
nano-particle
mediated
approaches,
chemical
modulators,
combination
therapies.
Many
these
H2O2-amplifying
approaches
have
demonstrated
promising
anticancer
effects
selectivity
preclinical
investigations.
They
selectively
induce
cytotoxicity
while
sparing
normal
cells,
sensitize
resistant
modulate
the
tumor
microenvironment.
However,
challenges
remain
achieving
selectivity,
addressing
heterogeneity,
ensuring
efficient
delivery,
managing
safety
toxicity.
To
address
those
issues,
H2O2-generating
agents
been
combined
with
other
treatments
leading
optimized
This
review
focuses
agents/approaches
that
kill
via
H2O2-mediated
mechanisms.
Different
categories
compounds
generate
are
summarized,
their
underlying
function
elucidated,
clinical
studies
well
recent
advancements
discussed,
prospects
targeted
utility
explored.
By
understanding
potential
compounds,
researchers
can
pave
way
development
effective
personalized
treatments.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(48)
Опубликована: Авг. 16, 2022
Nanocatalytic
therapy,
involving
the
nanozyme-triggered
production
of
reactive
oxygen
species
(ROS)
in
tumor
microenvironment
(TME),
has
demonstrated
potential
but
nanozymes
still
face
challenges
activity
and
specificity
that
compromise
therapeutic
efficacy.
Herein,
we
report
a
strategy
based
on
single-atom
nanozyme
to
initiate
cascade
enzymatic
reactions
TME
for
tumor-specific
treatment.
The
cobalt-single-atom
nanozyme,
with
Co-N
coordination
N-doped
porous
carbon
(Co-SAs@NC),
displays
catalase-like
decomposes
cellular
endogenous
H2
O2
produce
,
subsequent
oxidase-like
converts
into
cytotoxic
superoxide
radicals
efficiently
kill
cells.
By
incorporation
doxorubicin,
therapy
achieves
significantly
enhanced
antitumor
effect
vivo.
Our
findings
show
TME-specific
catalytic
combined
chemotherapy
is
promising
efficient
therapy.
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Янв. 9, 2023
Abstract
Nanozymes
with
intrinsic
enzyme‐mimicking
activities
have
shown
great
potential
to
become
surrogates
of
natural
enzymes
in
many
fields
by
virtue
their
advantages
high
catalytic
stability,
ease
functionalization,
and
low
cost.
However,
due
the
lack
predictable
descriptors,
most
nanozymes
reported
past
been
obtained
mainly
through
trial‐and‐error
strategies,
efficacy,
substrate
specificity,
as
well
practical
application
effect
under
physiological
conditions,
are
far
inferior
that
enzymes.
To
optimize
efficacies
functions
biomedical
settings,
recent
studies
introduced
biosystem‐inspired
strategies
into
nanozyme
design.
In
this
review,
advances
engineering
leveraging
refined
structure
enzymes,
simulating
behavior
changes
process,
mimicking
specific
biological
processes
or
living
organisms,
introduced.
Furthermore,
currently
involved
applications
summarized.
More
importantly,
current
opportunities
challenges
design
discussed.
It
is
hoped
based
on
bioinspired
will
be
beneficial
for
constructing
new
generation
broadening
applications.
Journal of Functional Biomaterials,
Год журнала:
2022,
Номер
13(4), С. 289 - 289
Опубликована: Дек. 9, 2022
Electrospinning
is
an
advanced
technology
for
the
preparation
of
drug-carrying
nanofibers
that
has
demonstrated
great
advantages
in
biomedical
field.
Electrospun
nanofiber
membranes
are
widely
used
field
drug
administration
due
to
their
such
as
large
specific
surface
area
and
similarity
extracellular
matrix.
Different
electrospinning
technologies
can
be
prepare
different
structures,
those
with
a
monolithic
structure,
core–shell
Janus
or
porous
structure.
It
also
possible
controlled-release
functions,
sustained
release,
delayed
biphasic
targeted
release.
This
paper
elaborates
on
drug-loaded
using
various
concludes
mechanisms
behind
controlled
release
drugs.
Polymers,
Год журнала:
2023,
Номер
15(4), С. 921 - 921
Опубликована: Фев. 12, 2023
Electrospun
porous
nanofibers
have
gained
a
lot
of
interest
recently
in
various
fields
because
their
adjustable
structure,
high
specific
surface
area,
and
large
number
active
sites,
which
can
further
enhance
the
performance
materials.
This
paper
provides
an
overview
common
polymers,
preparation,
applications
electrospun
nanofibers.
Firstly,
polymers
commonly
used
to
construct
structures
main
pore-forming
methods
by
electrospinning,
namely
template
method
phase
separation
method,
are
introduced.
Secondly,
recent
air
purification,
water
treatment,
energy
storage,
biomedicine,
food
packaging,
sensor,
sound
wave
absorption,
flame
retardant,
heat
insulation
reviewed.
Finally,
challenges
possible
research
directions
for
future
study
discussed.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(16)
Опубликована: Янв. 4, 2024
Abstract
As
a
powerful
tool,
nanozyme
catalysts
broaden
the
avenues
to
implement
bio‐inspired
solutions
for
addressing
many
important
concerns,
covering
energy,
healthcare,
environment,
and
more.
Recent
endeavors,
characterized
by
atomic
precision,
have
enabled
extensive
exploration
of
single‐atom
nanozymes
(SAzymes)
with
high
catalytic
activity,
superior
substrate
selectivity,
integrated
multifunctionalities,
thus
becoming
an
emerging
field
that
bridges
nanotechnology
biology.
This
review
provides
brief
outline
progress
summarizes
latest
research
advances
regarding
SAzymes
in
biomedical
therapeutics,
mainly
including
tumor
therapy,
wound
antibacterial
tissue
anti‐inflammatory
focus
on
their
prototypical
synthesis
therapeutic
mechanisms.
Finally,
current
challenges
future
perspectives
engineering
advanced
are
also
discussed
outlooked.
It
is
anticipated
this
area
shall
provide
useful
guidance
therapy.
Biomolecules,
Год журнала:
2023,
Номер
13(1), С. 184 - 184
Опубликована: Янв. 16, 2023
Herbal
medicine
has
a
long
history
of
medical
efficacy
with
low
toxicity,
side
effects
and
good
biocompatibility.
However,
the
bioavailability
extract
raw
herbs
bioactive
compounds
is
poor
because
their
water
solubility.
In
order
to
overcome
solubility
issues,
electrospinning
technology
can
offer
delivery
alternative
resolve
them.
The
electrospun
fibers
have
advantages
high
specific
surface
area,
porosity,
excellent
mechanical
strength
flexible
structures.
At
same
time,
various
natural
synthetic
polymer-bound
mimic
extracellular
matrix
applications
in
different
fields.
this
paper,
development
polymers
used
for
incorporating
herbal
into
nanofibers
are
reviewed.
Finally,
recent
progress
these
biomedical
(drug
delivery,
wound
dressing,
tissue
engineering)
food
fields
along
future
prospects
discussed.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 15, 2023
Bacterial
prostatitis
is
a
challenging
condition
to
treat
with
traditional
dosage
forms.
Physicians
often
prescribe
variety
of
forms
different
administration
methods,
which
fail
provide
an
efficient
and
convenient
mode
drug
delivery.
The
aim
this
work
was
develop
new
type
hybrid
material
incorporating
both
electrosprayed
core-shell
microparticles
electrospun
nanofibers.
A
Chinese
medicine
(Ningmitai,
NMT)
Western
(ciprofloxacin,
CIP)
were
co-encapsulated
within
designed
be
released
in
separately
controlled
manner.
Utilizing
polyvinylpyrrolidone
(PVP)
as
hydrophilic
filament-forming
polymer
pH-sensitive
Eudragit
®
S100
(ES100)
the
particulate
polymeric
matrix,
combined
electrohydrodynamic
atomization
(EHDA)
method
comprising
coaxial
electrospraying
blending
electrospinning,
used
create
hybrids
single-step
straightforward
series
characterization
methods
conducted
analyze
working
process
its
final
products.
Scanning
electron
microscopy
transmission
revealed
that
EHDA
comprised
CIP-PVP
nanofibers
NMT-ES100
microparticles.
Multiple
confirmed
rapid
release
CIP
sustained
NMT.
antibacterial
experiments
indicated
exhibited
more
potent
effect
against
Escherichia
coli
dh5α
Bacillus
subtilis
Wb800
than
either
separate
or
amalgamation
fibrous
nanomedicine
micromedicine
can
expand
horizon
types
medicines.
integration
electrospinning
provides
approach
fabrication.
By
combining
soluble
polymers
hybrids,
we
ensure
sequential
NMT
for
potential
synergistic
therapy
bacterial
prostatitis.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 27, 2024
Surgery
is
the
mainstay
of
treatment
modality
for
malignant
melanoma.
However,
deteriorative
hypoxic
microenvironment
after
surgery
recognized
as
a
stemming
cause
tumor
recurrence/metastasis
and
delayed
wound
healing.
Here
we
design
construct
sprayable
therapeutic
hydrogel
(HIL@Z/P/H)
encapsulating
tumor-targeted
nanodrug
photosynthetic
cyanobacteria
(PCC
7942)
to
prevent
while
promote
In
postsurgical
B16F10
melanoma
model
in
female
mice,
can
disrupt
cellular
redox
homeostasis
via
photodynamic
therapy-induced
cascade
reactions
within
cells.
Besides,
photosynthetically
generated
O
Catalysts,
Год журнала:
2023,
Номер
13(4), С. 758 - 758
Опубликована: Апрель 15, 2023
Dyes,
antibiotics,
heavy
metal
ions,
and
bacteria
are
important
sources
of
water
pollution.
How
to
solve
these
issues
has
become
a
problem
in
the
fields
science
technology.
People
have
developed
variety
technologies
treat
pollutants
water.
Photocatalytic
technology
came
into
being.
As
simple
environmentally
friendly
treatment
technology,
it
been
widely
studied
by
scientific
community.
Traditional
powder
photocatalysts
cause
secondary
pollution
environment
not
conducive
recycling.
Therefore,
large
specific
surface
area
reusable
membrane
built
electrospinning
favorite
today’s
Nanofiber
membranes
prepared
structures,
which
can
meet
needs
different
occasions.
This
review
summarizes
discusses
research
progress
relationship
between
structure
electrospun
fiber
membranes,
their
impacts
on
photocatalytic
performance
nanofiber
membranes.
The
performance,
challenges,
future
development
directions
with
kinds
techniques
using
photocatalysis
pollutants,
reviewed.
