International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9556 - 9556
Опубликована: Сен. 3, 2024
Personal
protective
equipment
(PPE)
has
attracted
more
attention
since
the
outbreak
of
epidemic
in
2019.
Advanced
nano
techniques,
such
as
electrospinning,
can
provide
new
routes
for
developing
novel
PPE.
However,
electrospun
antibacterial
PPE
is
not
easily
obtained.
Fibers
loaded
with
photosensitizers
prepared
using
single-fluid
electrospinning
have
a
relatively
low
utilization
rate
due
to
influence
embedding
and
their
inadequate
mechanical
properties.
For
this
study,
monolithic
nanofibers
core–shell
were
compared.
Monolithic
F1
fibers
comprising
polyethylene
oxide
(PEO),
poly(vinyl
alcohol-co-ethylene)
(PVA-co-PE),
photo-antibacterial
agent
vitamin
K3
(VK3)
created
blending
process.
Core–shell
F2
coaxial
which
extensible
material
PEO
was
set
core
section,
composite
consisting
PEO,
PVA-co-PE,
VK3
shell
section.
Both
designed
structural
properties
had
an
average
diameter
approximately
1.0
μm,
determined
scanning
electron
microscopy
transmission
microscopy.
amorphously
dispersed
within
polymeric
matrices
compatible
manner,
revealed
X-ray
diffraction
Fourier
transform
infrared
spectroscopy.
higher
tensile
strength
2.917
±
0.091
MPa,
whereas
longer
elongation
break
194.567
0.091%.
Photoreaction
tests
showed
that,
adjustment,
could
produce
0.222
μmol/L
·OH
upon
illumination.
slightly
better
performance
than
fibers,
inhibition
zones
1.361
0.012
cm
1.296
0.022
E.
coli
S.
aureus,
respectively,
but
less
VK3.
The
intentional
tailoring
components
compositions
nanostructures
improve
process–structure–performance
relationship
potential
sunlight-activated
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
The
shapes
of
micro‐
and
nano‐products
have
profound
influences
on
their
functional
performances,
which
has
not
received
sufficient
attention
during
the
past
several
decades.
Electrohydrodynamic
atomization
(EHDA)
techniques,
mainly
include
electrospinning
electrospraying,
are
facile
in
manipulate
products'
shapes.
In
this
review,
generated
using
EHDA
for
modifying
drug
release
profiles
reviewed.
These
linear
nanofibers,
round
micro‐/nano‐particles,
beads‐on‐a‐string
hybrids.
They
can
be
further
divided
into
different
kinds
sub‐shapes,
explored
providing
desired
pulsatile
release,
sustained
biphasic
delayed
pH‐sensitive
release.
Additionally,
resulted
from
organizations
electrospun
nanofibers
discussed
delivery,
inner
structures
considered
together
developing
novel
delivery
systems.
future,
related
shape–performance
relationships
at
nanoscale,
besides
size,
structure
structure–performance
relationships,
would
play
important
roles
promoting
developments
field.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Фев. 5, 2024
Diabetic
wounds
are
a
significant
subset
of
chronic
characterized
by
elevated
levels
inflammatory
cytokines,
matrix
metalloproteinases
(MMPs),
and
reactive
oxygen
species
(ROS).
They
also
associated
with
impaired
angiogenesis,
persistent
infection,
high
likelihood
hospitalization,
leading
to
substantial
economic
burden
for
patients.
In
severe
cases,
amputation
or
even
mortality
may
occur.
foot
ulcers
(DFUs)
common
complication
diabetes,
up
25%
diabetic
patients
being
at
risk
developing
over
their
lifetime,
more
than
70%
ultimately
requiring
amputation.
Electrospun
scaffolds
exhibit
structural
similarity
the
extracellular
(ECM),
promoting
adhesion,
growth,
migration
fibroblasts,
thereby
facilitating
formation
new
skin
tissue
wound
site.
The
composition
size
electrospun
can
be
easily
adjusted,
enabling
controlled
drug
release
through
fiber
structure
modifications.
porous
nature
these
facilitates
gas
exchange
absorption
exudate.
Furthermore,
surface
readily
modified
impart
specific
functionalities,
making
electrospinning
nanofiber
highly
promising
treatment
wounds.
This
article
provides
concise
overview
healing
process
in
normal
pathological
mechanisms
underlying
wounds,
including
complications
such
as
ulcers.
It
explores
advantages
treatment.
Additionally,
it
summarizes
findings
from
various
studies
on
use
different
types
reviews
methods
loading
onto
scaffolds.
These
advancements
broaden
horizon
effectively
treating
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(2)
Опубликована: Март 1, 2024
Core-shell
structure
is
a
concentric
circle
found
in
nature.
The
rapid
development
of
electrospinning
technology
provides
more
approaches
for
the
production
core-shell
nanofibers.
nanoscale
effects
and
expansive
specific
surface
area
nanofibers
can
facilitate
dissolution
drugs.
By
employing
ingenious
structural
designs
judicious
polymer
selection,
specialized
nanofiber
drug
delivery
systems
be
prepared
to
achieve
controlled
release.
synergistic
combination
materials
exhibits
strong
strategy
enhancing
utilization
efficiency
customizing
release
profile
Consequently,
multi-chamber
hold
great
promise
highly
efficient
disease
treatment.
However,
little
attention
concentration
focused
on
effect
In
this
review,
we
introduced
different
fabrication
techniques
nanostructures,
including
advanced
technologies
functionalization.
Subsequently,
reviewed
behaviors
their
potential
needs
comprehensive
elucidation
based
electrospun
nanostructures
could
inspire
exploration
novel
systems.
Furthermore,
once
these
fibers
with
customizable
profiles
move
toward
industrial
mass
production,
they
will
potentially
promote
pharmacy
treatment
various
diseases.
This
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies.
Polymers,
Год журнала:
2024,
Номер
16(4), С. 504 - 504
Опубликована: Фев. 12, 2024
In
the
21st
century,
chemotherapy
stands
as
a
primary
treatment
method
for
prevalent
diseases,
yet
drug
resistance
remains
pressing
challenge.
Utilizing
electrospinning
to
support
drugs
offers
sustained
and
controlled
release
methods
in
contrast
oral
implantable
delivery
modes,
which
enable
localized
of
distinct
tumor
types.
Moreover,
core–sheath
structure
bears
advantages
dual-drug
loading:
core
sheath
layers
can
carry
different
drugs,
facilitating
collaborative
counter
resistance.
This
approach
minimizes
patient
discomfort
associated
with
multiple-drug
administration.
Electrospun
fibers
not
only
transport
but
also
integrate
metal
particles
targeted
compounds,
enabling
combinations
magnetic
heat
therapies
comprehensive
cancer
treatment.
review
delves
into
preparation
techniques
tailored
various
cancers,
foreseeing
their
promising
roles
Nanomaterials,
Год журнала:
2024,
Номер
14(7), С. 646 - 646
Опубликована: Апрель 8, 2024
Dressings
with
multiple
functional
performances
(such
as
hemostasis,
promoting
regeneration,
analgesia,
and
anti-inflammatory
effects)
are
highly
desired
in
orthopedic
surgery.
Herein,
several
new
kinds
of
medicated
nanofibers
loaded
active
ingredients
for
providing
functions
were
prepared
using
the
modified
coaxial
electrospinning
processes.
With
an
electrospinnable
solution
composed
polycaprolactone
fenoprofen
core
working
fluid,
different
types
unspinnable
fluids
(including
pure
solvent,
nanosuspension
containing
tranexamic
acid
hydroxyapatite,
dilute
polymeric
comprising
acid,
polyvinylpyrrolidone)
explored
to
implement
processes
creating
multifunctional
nanofibers.
Their
morphologies
inner
structures
assessed
through
scanning
transmission
electron
microscopes,
which
all
showed
a
linear
format
without
discerned
beads
or
spindles
diameter
smaller
than
1.0
μm,
some
them
had
incomplete
core–shell
nanostructures,
represented
by
symbol
@.
Additionally,
strange
details
about
sheaths’
topographies
observed,
included
cracks,
adhesions,
embedded
nanoparticles.
XRD
FTIR
verified
that
drugs
presented
amorphous
state,
resulted
from
fine
compatibility
among
involved
components.
All
samples
demonstrated
have
hydrophilic
property
exhibited
lower
water
contact
angle
40°
300
ms.
In
vitro
dissolution
tests
indicated
was
released
sustained
manner
over
6
h
typical
Fickian
diffusion
mechanism.
Hemostatic
intentional
distribution
on
shell
sections
able
endow
rapid
hemostatic
effect
within
60
s.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
