Advanced Materials,
Год журнала:
2023,
Номер
36(2)
Опубликована: Ноя. 14, 2023
Biomaterials
are
extensively
used
to
mimic
cell-matrix
interactions,
which
essential
for
cell
growth,
function,
and
differentiation.
This
is
particularly
relevant
when
developing
in
vitro
disease
models
of
organs
rich
extracellular
matrix,
like
the
liver.
Liver
involves
a
chronic
wound-healing
response
with
formation
scar
tissue
known
as
fibrosis.
At
early
stages,
liver
can
be
reverted,
but
progresses,
reversion
no
longer
possible,
there
cure.
Research
new
therapies
hampered
by
lack
adequate
that
replicate
mechanical
properties
biochemical
stimuli
present
fibrotic
Fibrosis
associated
changes
composition
matrix
directly
influence
behavior.
could
play
an
role
better
emulating
microenvironment.
In
this
paper,
recent
cutting-edge
biomaterials
creating
human
fibrosis
revised,
combination
cells,
bioprinting,
and/or
microfluidics.
These
technologies
have
been
instrumental
intricate
structure
unhealthy
promote
medium
perfusion
improves
growth
respectively.
A
comprehensive
analysis
impact
material
hints
cell-material
interactions
tridimensional
context
provided.
Bioactive Materials,
Год журнала:
2022,
Номер
20, С. 574 - 597
Опубликована: Июль 1, 2022
The
osteochondral
defect
repair
has
been
most
extensively
studied
due
to
the
rising
demand
for
new
therapies
diseases
such
as
osteoarthritis.
Tissue
engineering
proposed
a
promising
strategy
meet
of
simultaneous
regeneration
both
cartilage
and
subchondral
bone
by
constructing
integrated
gradient
tissue-engineered
scaffold
(IGTEOS).
This
review
brought
forward
main
challenges
establishing
satisfactory
IGTEOS
from
perspectives
complexity
physiology
microenvironment
tissue,
limitations
obtaining
desired
required
scaffold.
Then,
we
comprehensively
discussed
summarized
current
efforts
resolve
above
challenges,
including
architecture
strategies,
fabrication
techniques
Materials,
Год журнала:
2023,
Номер
16(15), С. 5459 - 5459
Опубликована: Авг. 3, 2023
The
treatment
of
skin
wounds
caused
by
trauma
and
pathophysiological
disorders
has
been
a
growing
healthcare
challenge,
posing
great
economic
burden
worldwide.
use
appropriate
wound
dressings
can
help
to
facilitate
the
repair
healing
rate
defective
skin.
Natural
polymer
biomaterials
such
as
collagen
hyaluronic
acid
with
excellent
biocompatibility
have
shown
promote
restoration
However,
low
mechanical
properties
fast
degradation
limited
their
applications.
Skin
based
on
biodegradable
biocompatible
synthetic
polymers
not
only
overcome
shortcomings
natural
but
also
possess
favorable
for
applications
in
wounds.
Herein,
we
listed
several
used
dressing
materials,
PVA,
PCL,
PLA,
PLGA,
PU,
PEO/PEG,
focusing
composition,
fabrication
techniques,
functions
promoting
healing.
Additionally,
future
development
prospects
polymer-based
are
put
forward.
Our
review
aims
provide
new
insights
further
using
polymers.
Journal of Clinical Medicine,
Год журнала:
2021,
Номер
10(21), С. 4966 - 4966
Опубликована: Окт. 26, 2021
Regenerative
medicine
is
an
emerging
field
that
centers
on
the
restoration
and
regeneration
of
functional
components
damaged
tissue.
Tissue
engineering
application
regenerative
seeks
to
create
tissue
whole
organs.
Using
3D
printing
technologies,
native
mimics
can
be
created
utilizing
biomaterials
living
cells.
Recently,
has
begun
employ
bioprinting
methods
highly
specialized
models
improve
upon
conventional
methods.
Here,
we
review
use
in
advancement
by
describing
process
its
advantages
over
other
Materials
techniques
are
also
reviewed,
addition
future
clinical
applications,
challenges,
directions
field.
Frontiers in Physiology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 22, 2022
Recently,
research
is
undergoing
a
drastic
change
in
the
application
of
animal
model
as
unique
investigation
strategy,
considering
an
alternative
approach
for
development
science
future.
Although
conventional
monolayer
cell
cultures
represent
established
and
widely
used
vitro
method,
lack
tissue
architecture
complexity
such
fails
to
inform
true
biological
processes
vivo
.
Recent
advances
culture
techniques
have
revolutionized
tools
biomedical
by
creating
powerful
three-dimensional
(3D)
models
recapitulate
heterogeneity,
structure
functions
primary
tissues.
These
also
bridge
gap
between
traditional
two-dimensional
(2D)
single-layer
models.
3D
systems
allow
researchers
recreate
human
organs
diseases
one
dish
thus
holds
great
promise
many
applications
regenerative
medicine,
drug
discovery,
precision
cancer
research,
gene
expression
studies.
Bioengineering
has
made
important
contribution
context
using
scaffolds
that
help
mimic
microenvironments
which
cells
naturally
reside,
supporting
mechanical,
physical
biochemical
requirements
cellular
growth
function.
We
therefore
speak
based
on
organoids,
bioreactors,
organ-on-a-chip
up
bioprinting
each
these
provides
its
own
advantages
applications.
All
prove
be
excellent
candidates
methods
testing,
well
revolutionizing
technology.
will
able
provide
new
ideas
study
interactions
both
basic
more
specialized
compliance
with
3R
principle.
In
this
review,
we
comparison
2D
culture,
details
some
different
currently
available
discussing
their
strengths
potential
Applied Bionics and Biomechanics,
Год журнала:
2022,
Номер
2022, С. 1 - 15
Опубликована: Фев. 9, 2022
Tissue
engineering
is
a
relatively
new
area
of
research
that
combines
medical,
biological,
and
fundamentals
to
create
tissue-engineered
constructs
regenerate,
preserve,
or
slightly
increase
the
functions
tissues.
To
mature
tissue,
extracellular
matrix
should
be
imitated
by
engineered
structures,
allow
for
oxygen
nutrient
transmission,
release
toxins
during
tissue
repair.
Numerous
recent
studies
have
been
devoted
developing
three-dimensional
nanostructures
engineering.
One
most
effective
these
methods
electrospinning.
nanofibrous
scaffolds
constructed
over
last
few
decades
repair
restoration.
The
current
review
gives
an
overview
attempts
construct
meshes
as
various
tissues
such
bone,
cartilage,
cardiovascular,
skin
Also,
article
addresses
improvements
difficulties
in
regeneration
using
Bioengineering,
Год журнала:
2022,
Номер
9(3), С. 109 - 109
Опубликована: Март 6, 2022
Novel
green
materials
not
sourced
from
animals
and
with
low
environmental
impact
are
becoming
increasingly
appealing
for
biomedical
cellular
agriculture
applications.
Marine
biomaterials
a
rich
source
of
structurally
diverse
compounds
various
biological
activities.
Kappa-carrageenan
(κ-c)
is
potential
candidate
tissue
engineering
applications
due
to
its
gelation
properties,
mechanical
strength,
similar
structural
composition
glycosaminoglycans
(GAGs),
possessing
several
advantages
when
compared
other
algae-based
typically
used
in
bioprinting
such
as
alginate.
For
those
reasons,
this
material
was
selected
the
main
polysaccharide
component
bioinks
developed
herein.
In
work,
pristine
κ-carrageenan
were
successfully
formulated
first
time
fabricate
3D
scaffolds
by
bioprinting.
Ink
formulation
printing
parameters
optimized,
allowing
manufacturing
complex
structures.
Mechanical
compression
tests
dry
weight
determination
revealed
young's
modulus
between
24.26
99.90
kPa
water
contents
above
97%.
Biocompatibility
assays,
using
mouse
fibroblast
cell
line,
showed
high
viability
attachment.
The
bioprinted
cells
spread
throughout
exhibiting
typical
fibroblast-like
morphology
controls.
bio-/printed
structures
remained
stable
under
culture
conditions
up
11
days,
preserving
values.
Overall,
we
established
strategy
manufacture
through
novel
agriculture.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(7)
Опубликована: Окт. 10, 2023
Abstract
Congenital
and
acquired
valvular
heart
diseases
(VHDs)
are
significant
causes
of
mortality
worldwide.
With
valve
replacement
being
the
primary
solution
for
VHD,
current
options
display
shortcomings,
including
calcification,
thrombogenicity,
hemodynamic
alteration,
leading
to
repetitive
surgeries.
Tissue
engineering,
however,
has
shown
great
potential
fabricating
valves
(HVs)
with
fewer
complications.
Here,
a
series
inks
developed,
combining
poly(vinyl
alcohol),
gelatin,
carrageenan
3D
printing
tissue‐engineered
(TEHVs).
The
inks/hydrogels
investigated
characterize
their
physico‐chemical,
morphological,
mechanical,
rheological
characteristics.
In
vitro
in
vivo
biocompatibility,
immune
response,
hemolysis,
thrombogenicity
also
evaluated.
Moreover,
hydrodynamics
TEHVs
under
physiological
conditions
reported.
Inks
demonstrate
mechanical
characteristics
comparable
native
leaflets.
Subcutaneous
implantation
reveals
that
hydrogels
do
not
induce
chronic
inflammation
can
undergo
remodeling.
hemocompatibility
assessments
show
minimal
hemolysis
low
thrombogenicity.
Different
sizes
types
HVs
successfully
printed
high
fidelity
air.
hydrodynamic
assessment
confirms
withstand
aortic
conditions.
Altogether,
3D‐printed
be
promising
alternative
solve
problems
associated
options.
