Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6253 - 6277

Опубликована: Июнь 1, 2024

Abstract: The tumor microenvironment (TME) is a complex and dynamic entity, comprising stromal cells, immune blood vessels extracellular matrix, which intimately associated with the occurrence development of cancers, as well their therapy. Utilizing shared characteristics tumors, such an acidic environment, enzymes hypoxia, researchers have developed promising cancer therapy strategy known responsive release nano-loaded drugs, specifically targeted at tissues or cells. In this comprehensive review, we provide in-depth overview current fundamentals state-of-the-art intelligent strategies TME-responsive nanoplatforms, include pH, high GSH levels, high-level adenosine triphosphate, overexpressed enzymes, hypoxia reductive environment. Additionally, showcase latest advancements in nanoparticles. conclusion, thoroughly examine immediate challenges prospects nanopharmaceuticals, expectation that progress these nanoformulations will enable exploitation, overcoming modulation TME, ultimately leading to significantly more effective Keywords: microenvironment, stimulus-responsive, drug delivery, therapy, biomedicine

Язык: Английский

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Tumor microenvironment responsive nanozymes for multimodal imaging of tumors

Nano TransMed, Год журнала: 2024, Номер 3, С. 100032 - 100032

Опубликована: Янв. 29, 2024

Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.

Язык: Английский

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Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.

Язык: Английский

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Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases

Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер 20(2), С. 101040 - 101040

Опубликована: Фев. 27, 2025

Cellular hitchhiking is an emerging therapeutic strategy that uses endogenous cell migration mechanism to deliver therapeutics specific sites in the body. Owing low permeability and presence of blood-brain barrier (BBB), targeted delivery limited, leading inadequate localization brain. NCs fail extravasate significantly into tumor microenvironment (TME), demonstrating poor accumulation penetration. The novel cellular concept has been utilized promote systemic half-life targeting. Neoplastic neuroinflammatory diseases brain, including glioblastoma neuroinflammation, face critical hurdles for efficiently delivering entities owing BBB. can surmount these by utilizing various populations, such as stem cells, monocytes/macrophages, neutrophils, platelets, potential functional carriers cargo through These carrier cells have innate capability traverse BBB, transit brain parenchyma, specifically reach disease inflammatory neoplastic lesions chemotactic navigation, i.e., movement attributed chemical stimuli. Chemotherapeutic drugs delivered achieve tumor-specific targeting discussed. This article explores types TME with in-depth mechanisms characterization techniques decipher backpack dissociation dynamics (nanoparticle payload detachment characteristics from hitchhiked cells) challenges toward prospective clinical translation.

Язык: Английский

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Nano-enabled colorectal cancer therapy

Journal of Controlled Release, Год журнала: 2023, Номер 362, С. 548 - 564

Опубликована: Сен. 9, 2023

Язык: Английский

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A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12001 - 12001

Опубликована: Июль 26, 2023

Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has advantages deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role process SDT, as their structure properties directly determine outcome. Inorganic sonosensitizers, with high stability longer circulation time human body, have great potential SDT. In this review, possible mechanisms SDT including ultrasonic cavitation, reactive oxygen species generation, activation immunity are briefly discussed. Then, latest research progress on inorganic sonosensitizers systematically summarized. Subsequently, strategies for optimizing efficacy introduced, combination image-guided therapy. The challenges future prospects sonodynamic It hoped that review will provide some guidance screening sonosensitizers.

Язык: Английский

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Acid-Resistant Nano-antioxidants Based on Epigallocatechin Gallate Alleviate Acute Intestinal and Kidney Inflammation

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(35), С. 46090 - 46101

Опубликована: Авг. 22, 2024

Epigallocatechin gallate (EGCG)-based nanosystems have garnered significant attention for their ability to alleviate inflammation due excellent anti-inflammatory properties and enhanced drug delivery capabilities. However, the degradation of EGCG in strongly acidic environments poses a challenge potential administration, particularly oral formulations, where gastric resistance is essential. In this study, we develop "disintegration reorganization" strategy create acid-resistant antioxidant nanoparticles (EGA NPs) based on 5-aminosalicylic acid (5-ASA) mitigating colitis acute kidney injury. At pH, ester bond breaks down, producing two building blocks. These, together with 5-ASA formaldehyde, form oligomers through combination phenol–aldehyde condensation Mannich reaction. The resulting self-assemble into EGA NPs, which exhibit stability under both neutral pH conditions. This makes them suitable allowing withstand harsh conditions, as well intravenous injection. Importantly, these retain EGCG, effectively scavenging reactive oxygen species reducing intracellular oxidative stress. Additionally, shows carrier, efficiently loading agent curcumin (Cur) Cur@EGA NPs. vivo studies demonstrate efficacy alleviating injury following respectively. These nanoparticulate formulations superior reduction compared free Cur vivo. Overall, our findings introduce novel nanoplatform treatment inflammation.

Язык: Английский

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Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(13), С. 3209 - 3225

Опубликована: Янв. 1, 2024

This review summarizes the recent advances of nanoplatform-based strategies to efficiently amplify tumoricidal capability PDT.

Язык: Английский

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Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Nano Today, Год журнала: 2024, Номер 57, С. 102386 - 102386

Опубликована: Июль 13, 2024

Язык: Английский

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Coordinating effect of ferroptosis and in situ disulfiram toxification for enhanced cancer therapy

Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149313 - 149313

Опубликована: Фев. 6, 2024

Язык: Английский

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