Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 723, P. 150173 - 150173
Published: May 24, 2024
Language: Английский
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6253 - 6277
Published: June 1, 2024
Abstract: The tumor microenvironment (TME) is a complex and dynamic entity, comprising stromal cells, immune blood vessels extracellular matrix, which intimately associated with the occurrence development of cancers, as well their therapy. Utilizing shared characteristics tumors, such an acidic environment, enzymes hypoxia, researchers have developed promising cancer therapy strategy known responsive release nano-loaded drugs, specifically targeted at tissues or cells. In this comprehensive review, we provide in-depth overview current fundamentals state-of-the-art intelligent strategies TME-responsive nanoplatforms, include pH, high GSH levels, high-level adenosine triphosphate, overexpressed enzymes, hypoxia reductive environment. Additionally, showcase latest advancements in nanoparticles. conclusion, thoroughly examine immediate challenges prospects nanopharmaceuticals, expectation that progress these nanoformulations will enable exploitation, overcoming modulation TME, ultimately leading to significantly more effective Keywords: microenvironment, stimulus-responsive, drug delivery, therapy, biomedicine
Language: Английский
Citations
22
Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100032 - 100032
Published: Jan. 29, 2024
Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.
Language: Английский
Citations
20
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 5, 2025
Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.
Language: Английский
Citations
2
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 548 - 564
Published: Sept. 9, 2023
Language: Английский
Citations
33
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12001 - 12001
Published: July 26, 2023
Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has advantages deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role process SDT, as their structure properties directly determine outcome. Inorganic sonosensitizers, with high stability longer circulation time human body, have great potential SDT. In this review, possible mechanisms SDT including ultrasonic cavitation, reactive oxygen species generation, activation immunity are briefly discussed. Then, latest research progress on inorganic sonosensitizers systematically summarized. Subsequently, strategies for optimizing efficacy introduced, combination image-guided therapy. The challenges future prospects sonodynamic It hoped that review will provide some guidance screening sonosensitizers.
Language: Английский
Citations
25
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(35), P. 46090 - 46101
Published: Aug. 22, 2024
Epigallocatechin gallate (EGCG)-based nanosystems have garnered significant attention for their ability to alleviate inflammation due excellent anti-inflammatory properties and enhanced drug delivery capabilities. However, the degradation of EGCG in strongly acidic environments poses a challenge potential administration, particularly oral formulations, where gastric resistance is essential. In this study, we develop "disintegration reorganization" strategy create acid-resistant antioxidant nanoparticles (EGA NPs) based on 5-aminosalicylic acid (5-ASA) mitigating colitis acute kidney injury. At pH, ester bond breaks down, producing two building blocks. These, together with 5-ASA formaldehyde, form oligomers through combination phenol–aldehyde condensation Mannich reaction. The resulting self-assemble into EGA NPs, which exhibit stability under both neutral pH conditions. This makes them suitable allowing withstand harsh conditions, as well intravenous injection. Importantly, these retain EGCG, effectively scavenging reactive oxygen species reducing intracellular oxidative stress. Additionally, shows carrier, efficiently loading agent curcumin (Cur) Cur@EGA NPs. vivo studies demonstrate efficacy alleviating injury following respectively. These nanoparticulate formulations superior reduction compared free Cur vivo. Overall, our findings introduce novel nanoplatform treatment inflammation.
Language: Английский
Citations
13
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3209 - 3225
Published: Jan. 1, 2024
This review summarizes the recent advances of nanoplatform-based strategies to efficiently amplify tumoricidal capability PDT.
Language: Английский
Citations
10
Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Composite nanozymes are composed of enzymes with similar or different catalytic capabilities and have higher activity than a single enzyme. In recent years, composite emerged as novel nanomaterial platforms for multiple applications in various research fields, where they used to produce oxygen, consume glutathione, toxic reactive oxygen species (ROS) cancer therapy. The therapeutic approach using is known chemo-dynamic therapy (CDT). Some also show special photothermal conversion effects, enabling them be combined pioneering treatments, such photodynamic (PDT), (PTT) sonodynamic (SDT), enhance the anti-cancer effects. this study, classification performances reviewed, along their advantages synthesis methods. Furthermore, treatment cancers emphasized, prospective challenges future discussed.
Language: Английский
Citations
1
Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Language: Английский
Citations
1
Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101040 - 101040
Published: Feb. 1, 2025
Language: Английский
Citations
1