Journal of Materials Chemistry C, Год журнала: 2024, Номер 12(29), С. 11012 - 11019
Опубликована: Янв. 1, 2024
By encapsulating luminol and Co 2+ within UiO-67-bpydc, we construct an enhanced chemiluminescence MOF material. UiO-67-bpydc⊃Co+Lu exhibits excellent sensing properties for H 2 O glucose, can accurately image skin inflammation.
Язык: Английский
ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.
Язык: Английский
Процитировано
202
Chemical Society Reviews, Год журнала: 2023, Номер 52(4), С. 1456 - 1490
Опубликована: Янв. 1, 2023
This review summarizes the synthesis, characterization and applications of AIE-active micelles. It is expected that this can guide future design micelle materials with fascinating structures functionalities.
Язык: Английский
Процитировано
71
Chemical Society Reviews, Год журнала: 2023, Номер 52(14), С. 4549 - 4566
Опубликована: Янв. 1, 2023
This tutorial review introduces recent advances in molecular afterglow imaging using organic materials with a focus on substrates, mechanisms, design principles of probes, and their biomedical applications.
Язык: Английский
Процитировано
58
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(24)
Опубликована: Апрель 13, 2023
Abstract There is growing interest in the development of chemiluminescence (CL) probes for phototheranostics because their minimized tissue autofluorescence. However, due to a lack near‐infrared (NIR)‐absorbing chemiluminophores, current NIR CL‐guided phototherapy are based on nanoparticles made up multiple components. We report bright unimolecular chemiluminophores with absorptions and emissions, long CL half‐lives ideal photodynamic efficiency. One luminophore modified into an activatable probe, DBP OL , turn‐on signal activity that specific cancer biomarker. The highly sensitive allows therapy which completely inhibits tumor growth lung metastasis mouse models, can be applied noninvasive monitoring metastasis. provide molecular guidelines NIR‐absorbing imaging‐guided phototherapy.
Язык: Английский
Процитировано
50
Chemical Reviews, Год журнала: 2023, Номер 123(24), С. 13966 - 14037
Опубликована: Ноя. 22, 2023
Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.
Язык: Английский
Процитировано
50
Small, Год журнала: 2023, Номер 19(31)
Опубликована: Март 25, 2023
Abstract Antibacterial photodynamic therapy (aPDT) is a promising antibiotics‐alternative strategy for bacterial infectious diseases, which features broad‐spectrum antibacterial activity with low risk of inducing resistance. However, clinical applications aPDT are still hindered by the hydrophobicity‐caused inadequate conventional photosensitizers and hypoxic microenvironment infections. To address these problems, herein, developed to achieve specific chemiluminescence (CL) imaging enhanced PDT infections using hemin‐modified carbon dots (H‐CDs). The H‐CDs can be facilely prepared exhibit favorable water solubility, augmented activity, unique peroxidase‐mimicking capacity. Compared free CDs, efficacy significantly due increased electron–hole separation efficiency. Moreover, peroxidase catalytic performance enables not only infection identification via microenvironment‐responsive CL but also oxygen self‐supplied hypoxia‐relief‐enhanced bacteria inactivation effects. Finally, efficiencies validated in both vivo abscess infected wound models. This work may provide an effective platform selective imaging‐guided treatment
Язык: Английский
Процитировано
49
Coordination Chemistry Reviews, Год журнала: 2024, Номер 507, С. 215717 - 215717
Опубликована: Март 5, 2024
Язык: Английский
Процитировано
47
Chemical Society Reviews, Год журнала: 2024, Номер 53(11), С. 5366 - 5393
Опубликована: Янв. 1, 2024
Recent advances in the design of AIE platinum complexes: structural regulation strategies, mechanisms, and applications.
Язык: Английский
Процитировано
39
Advanced Materials, Год журнала: 2023, Номер unknown
Опубликована: Сен. 22, 2023
Abstract The luminescence materials act as the key components in many functional devices, well detection and imaging systems, which can be permeated each aspect of modern life, attract more attention for creative technology applications. In addition to diverse properties organic luminogens, multiple molecular packing at aggregated states frequently offers new and/or exciting performance. However, there still lacks comprehensive analysis these materials, resulting an increased gap between design practical this review, from basic knowledge compounds single molecules, discernable property excimer, charge transfer (CT) complex or self‐assembly systems by adjacent finally opto‐electronic performance aggregates, relevant factors applications are discussed.
Язык: Английский
Процитировано
44
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(48)
Опубликована: Окт. 2, 2023
An accurate detection of lung metastasis is great significance for making better treatment choices and improving cancer prognosis, but remains a big challenge in clinical practice. In this study, we propose reinventing strategy to develop pH-activatable near-infrared (NIR) fluorescent nanoprobe, pulmonary tracer (denoted as PMT), based on assembly NIR dye IR780 calcium phosphate (CaP). By delicately tuning the intermolecular interactions during process doping content, well synthetic condition probe, fluorescence PMT could be finely adjusted via tumor acidity-triggered disassembly. Notably, selected PMT9 sharply convert subtle pH variations into distinct signal generate high ON/OFF contrast, dramatically reducing background signals. Benefiting from such preferable features, able precisely identify not only sites orthotopic models also metastases mice with remarkable signal-to-background ratio (SBR). This study provides unique turn shortcomings traditional vivo imaging advantages further expand application probe image associated lesions.
Язык: Английский
Процитировано
32