Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159771 - 159771
Опубликована: Янв. 1, 2025
Язык: Английский
Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(6), С. 449 - 467
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
95
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Март 21, 2024
Abstract Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design precise side-chain engineering generate •O 2 − •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed skeletons can electron-hole pairs sensitize H O into with photoexcitation, achieving NIR-photoexcited oxygen-independent production. Further, compared commonly used alkyl side chains, glycol oligomer as the chain mitigates recombination offers more molecules around generated from hydrophobic skeletons, which yield 4-fold stronger production, thus allowing an high PDT effect. Finally, feasibility of developing activatable PSs in female mice further demonstrated irradiation 15 mW cm −2 . study not only provides insights mechanism also general guideline develop NIR PDT.
Язык: Английский
Процитировано
69
EcoEnergy, Год журнала: 2023, Номер 1(2), С. 248 - 295
Опубликована: Дек. 1, 2023
Abstract In the advancing world of graphene, highly anisotropic 2D semiconductor nanosheets, notable for their nanometer‐scale thickness, have emerged as a leading innovation, displaying immense potential in exploration renewable and clean energy production. These garnered significant attention from researchers. The nanosheets are marked by extraordinary electronic, optical, chemical attributes, positioning them attractive foundational components heterogeneous photocatalysts. This review diligently summarizes both seminal work ongoing developments pertaining to application solar within context photocatalysis. We begin detailing distinctive properties concentrating on pivotal roles augmenting photocatalytic efficiency, explaining intrinsic mechanisms that govern migration rate photogenerated carriers material's surface. Subsequently, we delineate methods employed synthesize typical nanosheets. alignment with overarching objective expanding light absorption capacity accelerating charge transfer, also examine current research hybridization techniques involving materials varied dimensions, well deployment diverse applications. conclude identifying promising avenues challenges await further this burgeoning field.
Язык: Английский
Процитировано
64
Advanced Materials, Год журнала: 2024, Номер 36(23)
Опубликована: Фев. 27, 2024
Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.
Язык: Английский
Процитировано
48
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(31)
Опубликована: Сен. 14, 2023
Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.
Язык: Английский
Процитировано
44
Advanced Materials, Год журнала: 2024, Номер 36(15)
Опубликована: Янв. 17, 2024
Abstract Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer chronic diseases promote growth nanomedicine. However, there are very few analytical descriptive studies regarding trajectory nanomedicine, key research powers, present landscape, focal investigative points, future outlooks. Herein, articles reviews published Science Citation Index Expanded Web Core Collection from first January 2000 to 18th July 2023 analyzed. a bibliometric visualization publication trends, countries/regions, institutions, journals, categories, themes, references, keywords is produced elaborated. Nanomedicine‐related academic output increasing since COVID‐19 pandemic, solidifying uneven global distribution performance. While China leads terms quantity has numerous highly productive USA advantages impact, commercialization, industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, which drug delivery nanoparticles remain points. Current focuses on integrating nanomedicine cell ferroptosis induction immunotherapy. The keyword “burst testing” identifies promising directions, including immunogenic death, chemodynamic therapy, tumor microenvironment, immunotherapy, extracellular vesicles. prospects, major challenges, barriers addressing these directions discussed.
Язык: Английский
Процитировано
40
Advanced Science, Год журнала: 2024, Номер 11(20)
Опубликована: Март 19, 2024
Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in structural composition ease of modification LDHs makes it possible develop specifically functionalized meet needs different applications. In this review, recent advances applications, which include LDH‐based drug delivery systems, cancer diagnosis therapy, tissue engineering, coatings, functional membranes, biosensors, are comprehensively discussed. From these various research fields, can be seen that there is great potential possibility use However, at same time, must recognized actual clinical translation still very limited. Therefore, current limitations related on discussed by combining limited examples with requirements biomaterials. Finally, an outlook future provided.
Язык: Английский
Процитировано
34
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Biomaterials, Год журнала: 2023, Номер 303, С. 122391 - 122391
Опубликована: Ноя. 15, 2023
Язык: Английский
Процитировано
42
Advanced Science, Год журнала: 2023, Номер 10(24)
Опубликована: Июнь 17, 2023
Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.
Язык: Английский
Процитировано
38