Modulating the Surface Concentration and Lifetime of Active Hydrogen in Cu-Based Layered Double Hydroxides for Electrocatalytic Nitrate Reduction to Ammonia DOI
Hongmei Li, S Li,

Renjun Guan

и другие.

ACS Catalysis, Год журнала: 2024, Номер 14(16), С. 12042 - 12050

Опубликована: Июль 29, 2024

Strategies incorporating heterometals to introduce surface-active hydrogen (*H) have been extensively utilized enhance the electrocatalytic activity of Cu-based catalysts in nitrate reduction reaction (NitRR). However, a comprehensive understanding *H behavior and its specific impact on regulating NitRR pathway remains elusive, particularly quantitative manner. In this study, we prepared group layered double hydroxides (LDHs) as model with diverse concentrations lifetimes. Our findings reveal that LDHs is highly dependent species could be modulated by incorporated heterometallic sites. Specifically, conducted situ analysis different LDH using time-resolved scanning electrochemical microscopy. The surface concentration lifetime at various applied potentials were quantified, enabling us establish relationship between performance. Therefore, optimal performance was achieved CuNi-LDHs, exhibiting faradaic efficiency 94.6% yield rate 2.7 mg h–1 cm–2 because appropriate lifetime. Additionally, observe trend CuNi > CuCo Cu CuRu CuFe CuMg terms for NH3 production. These results suggest effectively utilizing stable produced catalyst, one would allow favorable performance, offering promising strategy other hydrogenation reactions.

Язык: Английский

Ultrathin Clay Nanoparticles‐Mediated Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy DOI Open Access
Jianping Liu,

Jiezhao Zhan,

Ye Zhang

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(9)

Опубликована: Ноя. 8, 2023

Ferroptosis-triggered immunogenic cell death (ICD) is widely adopted to potentiate the body's antitumor immunity by catalyzing production of toxic reactive oxygen species (ROS). However, efficacy ferroptosis and immunotherapy greatly restricted intracellular abundant glutathione (GSH) immunosuppressive tumor microenvironment (TME). Herein, a facile bottom-up method for solvent-free synthesis ultrathin manganese (Mn)-based layered double hydroxide nanosheets with high loading efficiency pro-inflammatory cytokine interferon (IFNγ) (IFNγ/uMn-LDHs) proposed mutually reinforce systemic immunity. The introduction ions significantly contributes GSH depletion hydroxyl radical generation, which can be further enhanced IFNγ delivery-induced SLC7A11 downregulation. ICD effect after cooperates intrinsic immunomodulatory property IFNγ/uMn-LDHs facilitate maturation dendritic cells (DCs) priming T cells. secretion from activated CD8

Язык: Английский

Процитировано

69
Dual-Responsive Triple-Synergistic Fe-MOF for Tumor Theranostics DOI
Zhiwei Chen,

Yaoji Sun,

Jiawei Wang

и другие.

ACS Nano, Год журнала: 2023, Номер 17(10), С. 9003 - 9013

Опубликована: Апрель 28, 2023

The intelligent responsive drug delivery system has great application potential in cancer precision therapy. Although many antitumor methods have been developed based on systems, most of them yet suffer from poor efficiency. In this project, a near-infrared and pH dual-response multimodal collaborative platform for diagnosis treatment (PCN-DOX@PDA) was constructed. We used PCN-600 as vehicle loaded with antineoplastic drugs polydopamine (PDA). Under 633 nm laser irradiation, the ligand tetrakis(4-carboxyphenyl)porphyrin (TCPP) can generate singlet oxygen (1O2) kill tumor cells. PDA is photothermal agent PTT. PCN-DOX@PDA achieves release by responding to weak acidity microenvironment thermal stimulation generated NIR irradiation. addition, since central ion PCN Fe3+, realizes tumors through magnetic resonance imaging-mediated chemotherapy photodynamic synergistic This triple strategy showed excellent biocompatibility ability vivo experiments 4T1 tumor-bearing mouse model, indicating that good development prospect field therapy diversified biomedical applications.

Язык: Английский

Процитировано

66
Functional nanoporous graphene superlattice DOI Creative Commons
Hualiang Lv, Yuxing Yao,

Mingyue Yuan

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 12, 2024

Abstract Two-dimensional (2D) superlattices, formed by stacking sublattices of 2D materials, have emerged as a powerful platform for tailoring and enhancing material properties beyond their intrinsic characteristics. However, conventional synthesis methods are limited to pristine sublattices, posing significant practical challenge when it comes chemically modified sublattices. Here we report chemical method that overcomes this creating unique graphene superlattice, with monodisperse, nanometer-sized, square-shaped pores strategically doped elements at the pore edges. The resulting superlattice exhibits remarkable correlations between quantum phases both electron phonon levels, leading diverse functionalities, such electromagnetic shielding, energy harvesting, optoelectronics, thermoelectrics. Overall, our findings not only provide design principles synthesizing understanding functional superlattices but also expand enhanced functionality extensive application potential compared counterparts.

Язык: Английский

Процитировано

66
Size engineering of 2D MOF nanosheets for enhanced photodynamic antimicrobial therapy DOI

Baoli Xue,

Xiwen Geng,

Haohao Cui

и другие.

Chinese Chemical Letters, Год журнала: 2023, Номер 34(9), С. 108140 - 108140

Опубликована: Янв. 14, 2023

Язык: Английский

Процитировано

56
Review of photo- and electro-catalytic multi-metallic layered double hydroxides DOI

Chenjun Ning,

Sha Bai, Jikang Wang

и другие.

Coordination Chemistry Reviews, Год журнала: 2023, Номер 480, С. 215008 - 215008

Опубликована: Янв. 17, 2023

Язык: Английский

Процитировано

55
Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy DOI
Ji‐Na Hao,

Kaiming Ge,

Guoli Chen

и другие.

Chemical Society Reviews, Год журнала: 2023, Номер 52(22), С. 7707 - 7736

Опубликована: Янв. 1, 2023

This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.

Язык: Английский

Процитировано

54
Synergistic Interaction between Metal Single‐Atoms and Defective WO3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy DOI Creative Commons
Zhan Zhou, Tao Wang, Tingting Hu

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(23)

Опубликована: Фев. 27, 2024

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.

Язык: Английский

Процитировано

49
Advanced materials in sorbent-based analytical sample preparation DOI

Elham Torabi,

Abbas Abdar,

Nahid Lotfian

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215680 - 215680

Опубликована: Фев. 13, 2024

Язык: Английский

Процитировано

47
Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields DOI Creative Commons
Cristian Nomicisio, Marco Ruggeri, Eleonora Bianchi

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1368 - 1368

Опубликована: Апрель 29, 2023

Clay minerals are historically among the most used materials with a wide variety of applications. In pharmaceutical and biomedical fields, their healing properties have always been known in pelotherapy therefore attractive for potential. recent decades, research has focused on systematic investigation these properties. This review aims to describe relevant uses clays field, especially drug delivery tissue engineering purposes. minerals, which biocompatible non-toxic materials, can act as carriers active ingredients while controlling release increasing bioavailability. Moreover, combination polymers is useful it improve mechanical thermal polymers, well induce cell adhesion proliferation. Different types clays, both natural (such montmorillonite halloysite) synthetic origin (layered double hydroxides zeolites), were considered order compare them assess advantages different uses.

Язык: Английский

Процитировано

45
CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy DOI

Aidi Hou,

Yuhang Du,

Yumeng Su

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(9), С. 10998 - 11007

Опубликована: Апрель 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Язык: Английский

Процитировано

42