Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 17, 2025
Background
Heart
failure
(HF)
is
a
prevalent
cardiovascular
disease
that
currently
lacks
effective
treatment
options
due
to
its
intricate
pathogenesis.
A
recent
study
has
linked
disulfidoptosis,
novel
form
of
cell
demise,
with
the
development
range
diseases.
Nonetheless,
effect
disulfidoptosis
on
immune
microenvironment
HF
not
well
comprehended.
In
this
paper,
bioinformatics
analysis
was
performed
investigate
how
disulfidptosis-related
genes
(DRGs)
affect
HF.
Methods
The
expression
four
DRGs
initially
examined
using
bulk
RNA-Seq
and
single-cell
RNA
sequencing
data.
predictive
model
subsequently
developed.
Consensus
clustering
used
distinguish
between
two
clusters
DRGs.
these
characteristics
further
explored,
such
as
infiltrating
cells,
response
gene
sets,
HLAs
genes.
Results
All
were
dysregulated
in
samples.
based
effectively
differentiated
patients
healthy
individuals,
which
validated
experiment.
These
strongly
associated
abundance
monocytes.
Moreover,
our
identified
distinct
exhibited
differences
terms
abundance,
response,
HLA
expression.
biological
functions
also
revealed.
Conclusion
Our
discovery
underscores
pivotal
role
shaping
diversity
intricacy
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Апрель 2, 2024
Abstract
Cancer
immunotherapy
and
vaccine
development
have
significantly
improved
the
fight
against
cancers.
Despite
these
advancements,
challenges
remain,
particularly
in
clinical
delivery
of
immunomodulatory
compounds.
The
tumor
microenvironment
(TME),
comprising
macrophages,
fibroblasts,
immune
cells,
plays
a
crucial
role
response
modulation.
Nanoparticles,
engineered
to
reshape
TME,
shown
promising
results
enhancing
by
facilitating
targeted
These
nanoparticles
can
suppress
fibroblast
activation,
promote
M1
macrophage
polarization,
aid
dendritic
cell
maturation,
encourage
T
infiltration.
Biomimetic
further
enhance
increasing
internalization
agents
cells
such
as
cells.
Moreover,
exosomes,
whether
naturally
secreted
body
or
bioengineered,
been
explored
regulate
TME
immune-related
affect
cancer
immunotherapy.
Stimuli-responsive
nanocarriers,
activated
pH,
redox,
light
conditions,
exhibit
potential
accelerate
co-application
with
checkpoint
inhibitors
is
an
emerging
strategy
boost
anti-tumor
immunity.
With
their
ability
induce
long-term
immunity,
nanoarchitectures
are
structures
development.
This
review
underscores
critical
overcoming
current
driving
advancement
modification.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(10)
Опубликована: Янв. 10, 2024
Dendritic
cell
(DC)
maturation
and
antigen
presentation
are
key
factors
for
successful
vaccine-based
cancer
immunotherapy.
This
study
developed
manganese-based
layered
double
hydroxide
(Mn-LDH)
nanoparticles
as
a
self-adjuvanted
vaccine
carrier
that
not
only
promoted
DC
through
synergistically
depleting
endogenous
glutathione
(GSH)
activating
STING
signaling
pathway,
but
also
facilitated
the
delivery
of
model
ovalbumin
(OVA)
into
lymph
nodes
subsequent
in
DCs.
Significant
therapeutic-prophylactic
efficacy
OVA-loaded
Mn-LDH
(OVA/Mn-LDH)
nanovaccine
was
determined
by
tumor
growth
inhibition
mice
bearing
B16-OVA
tumor.
Our
results
showed
OVA/Mn-LDH
could
be
potent
system
development
without
need
adjuvant.
Therefore,
combination
GSH
exhaustion
pathway
activation
might
an
advisable
approach
promoting
presentation,
finally
improving
efficacy.
Abstract
Sonodynamic
therapy
(SDT),
featuring
noninvasive,
deeper
penetration,
low
cost,
and
repeatability,
is
a
promising
approach
for
deep‐seated
tumors.
However,
the
general
or
only
utilization
of
SDT
shows
efficiency
unsatisfactory
treatment
outcomes
due
to
complicated
tumor
microenvironment
(TME)
process.
To
circumvent
issues,
three
feasible
approaches
enhancing
SDT‐based
therapeutic
effects,
including
sonosensitizer
optimization,
strategies
conquering
hypoxia
TME,
combinational
are
summarized,
with
particular
focus
on
combination
other
modalities,
chemodynamic
therapy,
photodynamic
photothermal
chemotherapy,
starvation
gas
immunotherapy.
In
end,
current
challenges
in
tumors
discussed
enhanced
effects
provided.
It
envisioned
that
this
review
will
provide
new
insight
into
strategic
design
high‐efficiency
sonosensitizer‐derived
nanotheranostics,
thereby
augmenting
accelerating
potential
clinical
transformation.
Normal
life
requires
cell
division
to
produce
new
cells,
but
death
is
necessary
maintain
balance.
Dysregulation
of
can
lead
the
survival
and
proliferation
abnormal
promoting
tumor
development.
Unlike
apoptosis,
necrosis,
autophagy,
newly
recognized
forms
regulated
(RCD)
cuproptosis,
ferroptosis,
PANoptosis
provide
novel
therapeutic
strategies
for
treatment.
Increasing
research
indicates
that
immune
cells
mediated
by
these
discovered
regulate
microenvironment
(TME)
influence
effectiveness
immunotherapy.
This
review
primarily
elucidates
molecular
mechanisms
their
complex
effects
on
TME.
also
summarizes
exploration
nanoparticle
applications
in
therapy
based
vivo
vitro
evidence
derived
from
induction
or
inhibition
RCD
pathways.
Materials Horizons,
Год журнала:
2024,
Номер
11(18), С. 4275 - 4310
Опубликована: Янв. 1, 2024
This
comprehensive
review
systematically
summarizes
the
intrinsic
mechanism
of
different
metal
ion
(such
as
Fe
3+
/Fe
2+
,
Cu
/Cu
+
Ca
Zn
Mn
Na
/K
and
Mg
)-mediated
interference
therapies
their
research
progress
in
cancer
treatment.
