Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(2)
Опубликована: Ноя. 29, 2023
Abstract
Dendritic
cell
vaccine
(DCV)
holds
great
potential
in
tumor
immunotherapy
owing
to
its
potent
ability
eliciting
tumor‐specific
immune
responses.
Aiming
at
engineering
enhanced
DCV,
we
report
the
first
effort
construct
a
glycopolymer‐engineered
DC
(G‐DCV)
via
metabolicglycoengineering
and
copper‐free
click‐chemistry.
Model
G‐DCV
was
prepared
by
firstly
delivering
antigens,
ovalbumin
(OVA)
into
dendritic
cells
(DC)
with
fluoroalkane‐grafted
polyethyleneimines,
followed
conjugating
glycopolymers
terminal
group
of
dibenzocyclooctyne
(DBCO)
onto
cells.
Compared
unmodified
our
could
induce
stronger
T
activation
due
adhesion
between
DCs
Notably,
such
more
effectively
inhibit
growth
mouse
B16‐OVA
(expressing
OVA
antigen)
model
after
adoptive
transfer.
Moreover,
combination
an
checkpoint
inhibitor,
showed
further
increased
anti‐tumor
effects
treating
different
models.
Thus,
work
provides
novel
strategy
enhance
therapeutic
effectiveness
vaccines.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Фев. 7, 2024
Cancer
nanovaccines
have
attracted
widespread
attention
by
inducing
potent
cytotoxic
T
cell
responses
to
improve
immune
checkpoint
blockade
(ICB)
therapy,
while
the
lack
of
co-stimulatory
molecules
limits
their
clinical
applications.
Here,
a
genetically
engineered
cancer
cytomembrane
nanovaccine
is
reported
that
simultaneously
overexpresses
molecule
CD40L
and
inhibitor
PD1
elicit
robust
antitumor
immunity
for
immunotherapy.
The
tumor
antigens
inherited
from
cytomembranes
effectively
stimulate
dendritic
(DC)-mediated
activation
cells,
on
significantly
blocks
PD1/PD-L1
signaling
pathway,
synergistically
stimulating
responses.
Benefiting
targeting
ability
cytomembranes,
this
formula
shows
an
enhanced
lymph
node
trafficking
retention.
Compared
with
original
induces
twofold
DC
maturation
satisfactory
precaution
efficacy
in
breast
mouse
model.
This
offers
simple,
safe,
strategy
incorporating
components
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(28), С. 19218 - 19228
Опубликована: Июль 2, 2024
The
messenger
RNA
(mRNA)
vaccines
hold
great
significance
in
contagion
prevention
and
cancer
immunotherapy.
However,
safely
effectively
harnessing
innate
immunity
to
stimulate
robust
durable
adaptive
immune
protection
is
crucial,
yet
challenging.
In
this
study,
we
synthesized
a
library
of
stimuli-responsive
bivalent
ionizable
lipids
(srBiv
iLPs)
with
smart
molecular
blocks
responsive
esterase,
H
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Pathogen-mimicking
nanoparticles
have
emerged
at
the
forefront
of
vaccine
delivery
technology,
offering
potent
immune
activation
and
excellent
biocompatibility.
Among
these
innovative
carriers,
mannan,
a
critical
component
yeast
cell
walls,
shows
promise
as
an
exemplary
carrier.
Nevertheless,
it
faces
challenges
like
unpredictable
immunogenicity,
rapid
elimination,
limited
antigen
loading
due
to
high
water
solubility.
Herein,
mannan
with
varying
carbon
chain
ratios
is
innovatively
modified,
yielding
series
dodecyl
chains
modified
(Mann-C
Abstract
The
use
of
cancer
immunotherapeutics
is
currently
increasing.
Cancer
vaccines,
as
a
form
immunotherapy,
are
gaining
much
attention
in
the
medical
community
since
specific
tumor-antigens
can
activate
immune
cells
to
induce
an
anti-tumor
response.
However,
delivery
vaccines
presents
many
issues
for
research
scientists
when
designing
treatments
and
requires
further
investigation.
Nanoparticles,
synthetic
liposomes,
bacterial
vectors,
viral
particles,
mammalian
exosomes
have
delivered
vaccines.
In
contrast,
these
nanotechnologies
produces
cytotoxicity,
immunogenicity,
rapid
clearance
by
mononuclear
phagocyte
system
(MPS).
Plant-exosome-like
nanovesicles
(PELNVs)
provide
solutions
challenges
because
they
innocuous
nonimmunogenic
delivering
nanomedicines.
Hence,
this
review
will
describe
potential
PELNVs
deliver
review,
different
approaches
vaccine
be
detailed,
mechanism
oral
vaccination
described,
discuss
improved
drug
systems
via
administration
while
also
addressing
subsequent
advancing
their
usage
into
clinical
setting.
