Coordination Chemistry Reviews, Год журнала: 2025, Номер 538, С. 216718 - 216718
Опубликована: Апрель 22, 2025
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Язык: Английский
Процитировано
158
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Сен. 15, 2024
The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll-like to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific sustained killing via B cells, T antibodies. Traditionally, it has been assumed that activates immunity; however, recent studies have revealed more complex interactions. This review a detailed dissection composition function systems, emphasizing their synergistic roles in physiological pathological contexts, providing new insights into link between these two forms immunity. Precise regulation both systems at same time is beneficial fight against immune-related diseases, for example, cGAS-STING pathway found play an important role infections cancers. In addition, paper summarizes challenges future directions field immunity, including latest single-cell sequencing technologies, CAR-T cell therapy, checkpoint inhibitors. By summarizing developments, aims enhance our understanding complexity interactions perspectives system.
Язык: Английский
Процитировано
23
Chemical Society Reviews, Год журнала: 2024, Номер 53(7), С. 3224 - 3252
Опубликована: Янв. 1, 2024
Neoantigens play a pivotal role in the field of tumour therapy, encompassing stimulation anti-tumour immune response and enhancement targeting capability. Nonetheless, numerous factors directly influence effectiveness neoantigens bolstering responses, including neoantigen quantity specificity, uptake rates by antigen-presenting cells (APCs), residence duration within microenvironment (TME), their ability to facilitate maturation APCs for activation. Nanotechnology assumes significant several aspects, facilitating release, promoting delivery cells, augmenting dendritic shielding from protease degradation, optimizing interactions between system. Consequently, development nanotechnology synergistically enhances efficacy cancer theranostics. In this review, we provide an overview sources, mechanisms neoantigen-induced evolution precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic other strategies tailored augment therapeutics. We also discuss current challenges prospects application nanomedicine, aiming expedite its clinical translation.
Язык: Английский
Процитировано
19
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.
Язык: Английский
Процитировано
3
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 91, С. 105270 - 105270
Опубликована: Дек. 14, 2023
Язык: Английский
Процитировано
24
Advanced Functional Materials, Год журнала: 2024, Номер 34(29)
Опубликована: Апрель 5, 2024
Abstract Rapid advances in nanotechnology have made it possible to combine photothermal therapy (PTT) with immunotherapy, enabling activate an situ vaccine effect. However, this effect is severely impeded by low antigen presentation level and highly suppressive tumor immune microenvironment (immune “cold” tumors). To overcome the obstacles, multifunctional carrier‐free nanoparticles (FCDP‐NPs) assembled from Fe 2+ , toll‐like receptor 9 agonist (CpG), cationic lipid (DOTAP) agent polydopamine are developed. After intratumoral injection, FCDP‐NPs carrying positive charge exposed under laser irradiation, which can capture tumor‐associated antigens (TAAs) generated upon post‐PTT form nanovaccines (FCD‐NPs@TAAs). The further promote cross‐presentation of TAAs, stimulate adaptive responses, shape “hot” tumors. As a result, improve survival rates elicit durable memory that remarkedly prevents metastasis, illustrating useful platform for PTT synergized immunotherapy.
Язык: Английский
Процитировано
15
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Increasing evidence illustrates the significance of promoting tumor immunogenicity and an efficient immune response in immunotherapy, but immunosuppressive microenvironment (TME) remains obstacle. Herein, AlZn hydrotalcite (AZOH) was synthesized as a pyroptosis inducer further loaded with R848 to formulate R@AZOH. R@AZOH efficiently triggered CT26 cell through Zn2+ overload-evoked mitochondrial dysfunction its downstream caspase-1/GSDMD pathway, resulting release inflammatory cytokines, membrane fracture, immunogenic death (ICD). Moreover, served antigen traps facilitate presentation, thereby cooperating TLR activation dually stimulate dendritic cells (DCs). The combination rapidly initiated innate immunity prolonged adaptive response, suppression growth, "hot" niche. potent antitumor enhanced by checkpoint inhibitor (αCTLA-4), which inhibited both primary distant tumors, well systemic activation. Astonishingly, we also explored potential application vaccine adjuvant demonstrated ability elicit immunological memory prevent growth orthotopic melanoma model. Overall, our work emphasized combining overcome TME presented good candidate.
Язык: Английский
Процитировано
1
Nano Today, Год журнала: 2024, Номер 56, С. 102273 - 102273
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
7
Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 547 - 563
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
7
Biomaterials, Год журнала: 2025, Номер 320, С. 123254 - 123254
Опубликована: Март 11, 2025
Язык: Английский
Процитировано
1