Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216718 - 216718
Published: April 22, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
158
MedComm, Journal Year: 2024, Volume and Issue: 5(10)
Published: Sept. 15, 2024
The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll-like to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific sustained killing via B cells, T antibodies. Traditionally, it has been assumed that activates immunity; however, recent studies have revealed more complex interactions. This review a detailed dissection composition function systems, emphasizing their synergistic roles in physiological pathological contexts, providing new insights into link between these two forms immunity. Precise regulation both systems at same time is beneficial fight against immune-related diseases, for example, cGAS-STING pathway found play an important role infections cancers. In addition, paper summarizes challenges future directions field immunity, including latest single-cell sequencing technologies, CAR-T cell therapy, checkpoint inhibitors. By summarizing developments, aims enhance our understanding complexity interactions perspectives system.
Language: Английский
Citations
23
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3224 - 3252
Published: Jan. 1, 2024
Neoantigens play a pivotal role in the field of tumour therapy, encompassing stimulation anti-tumour immune response and enhancement targeting capability. Nonetheless, numerous factors directly influence effectiveness neoantigens bolstering responses, including neoantigen quantity specificity, uptake rates by antigen-presenting cells (APCs), residence duration within microenvironment (TME), their ability to facilitate maturation APCs for activation. Nanotechnology assumes significant several aspects, facilitating release, promoting delivery cells, augmenting dendritic shielding from protease degradation, optimizing interactions between system. Consequently, development nanotechnology synergistically enhances efficacy cancer theranostics. In this review, we provide an overview sources, mechanisms neoantigen-induced evolution precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic other strategies tailored augment therapeutics. We also discuss current challenges prospects application nanomedicine, aiming expedite its clinical translation.
Language: Английский
Citations
19
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.
Language: Английский
Citations
3
Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 91, P. 105270 - 105270
Published: Dec. 14, 2023
Language: Английский
Citations
24
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)
Published: April 5, 2024
Abstract Rapid advances in nanotechnology have made it possible to combine photothermal therapy (PTT) with immunotherapy, enabling activate an situ vaccine effect. However, this effect is severely impeded by low antigen presentation level and highly suppressive tumor immune microenvironment (immune “cold” tumors). To overcome the obstacles, multifunctional carrier‐free nanoparticles (FCDP‐NPs) assembled from Fe 2+ , toll‐like receptor 9 agonist (CpG), cationic lipid (DOTAP) agent polydopamine are developed. After intratumoral injection, FCDP‐NPs carrying positive charge exposed under laser irradiation, which can capture tumor‐associated antigens (TAAs) generated upon post‐PTT form nanovaccines (FCD‐NPs@TAAs). The further promote cross‐presentation of TAAs, stimulate adaptive responses, shape “hot” tumors. As a result, improve survival rates elicit durable memory that remarkedly prevents metastasis, illustrating useful platform for PTT synergized immunotherapy.
Language: Английский
Citations
15
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Increasing evidence illustrates the significance of promoting tumor immunogenicity and an efficient immune response in immunotherapy, but immunosuppressive microenvironment (TME) remains obstacle. Herein, AlZn hydrotalcite (AZOH) was synthesized as a pyroptosis inducer further loaded with R848 to formulate R@AZOH. R@AZOH efficiently triggered CT26 cell through Zn2+ overload-evoked mitochondrial dysfunction its downstream caspase-1/GSDMD pathway, resulting release inflammatory cytokines, membrane fracture, immunogenic death (ICD). Moreover, served antigen traps facilitate presentation, thereby cooperating TLR activation dually stimulate dendritic cells (DCs). The combination rapidly initiated innate immunity prolonged adaptive response, suppression growth, "hot" niche. potent antitumor enhanced by checkpoint inhibitor (αCTLA-4), which inhibited both primary distant tumors, well systemic activation. Astonishingly, we also explored potential application vaccine adjuvant demonstrated ability elicit immunological memory prevent growth orthotopic melanoma model. Overall, our work emphasized combining overcome TME presented good candidate.
Language: Английский
Citations
1
Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102273 - 102273
Published: April 23, 2024
Language: Английский
Citations
7
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 547 - 563
Published: July 29, 2024
Language: Английский
Citations
7
Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123254 - 123254
Published: March 11, 2025
Language: Английский
Citations
1