Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Language: Английский

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The interaction of innate immune and adaptive immune system

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 15, 2024

The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll-like to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific sustained killing via B cells, T antibodies. Traditionally, it has been assumed that activates immunity; however, recent studies have revealed more complex interactions. This review a detailed dissection composition function systems, emphasizing their synergistic roles in physiological pathological contexts, providing new insights into link between these two forms immunity. Precise regulation both systems at same time is beneficial fight against immune-related diseases, for example, cGAS-STING pathway found play an important role infections cancers. In addition, paper summarizes challenges future directions field immunity, including latest single-cell sequencing technologies, CAR-T cell therapy, checkpoint inhibitors. By summarizing developments, aims enhance our understanding complexity interactions perspectives system.

Language: Английский

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Advancing nanotechnology for neoantigen-based cancer theranostics

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3224 - 3252

Published: Jan. 1, 2024

Neoantigens play a pivotal role in the field of tumour therapy, encompassing stimulation anti-tumour immune response and enhancement targeting capability. Nonetheless, numerous factors directly influence effectiveness neoantigens bolstering responses, including neoantigen quantity specificity, uptake rates by antigen-presenting cells (APCs), residence duration within microenvironment (TME), their ability to facilitate maturation APCs for activation. Nanotechnology assumes significant several aspects, facilitating release, promoting delivery cells, augmenting dendritic shielding from protease degradation, optimizing interactions between system. Consequently, development nanotechnology synergistically enhances efficacy cancer theranostics. In this review, we provide an overview sources, mechanisms neoantigen-induced evolution precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic other strategies tailored augment therapeutics. We also discuss current challenges prospects application nanomedicine, aiming expedite its clinical translation.

Language: Английский

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Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Language: Английский

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Emerging innovations in vincristine-encapsulated nanoparticles: Pioneering a new era in oncological therapeutics

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 91, P. 105270 - 105270

Published: Dec. 14, 2023

Language: Английский

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Cascade Carrier‐Free Nanoparticles Forming In Situ Nanovaccines for Synergistic Photothermal‐Immunotherapy of Cancer

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: April 5, 2024

Abstract Rapid advances in nanotechnology have made it possible to combine photothermal therapy (PTT) with immunotherapy, enabling activate an situ vaccine effect. However, this effect is severely impeded by low antigen presentation level and highly suppressive tumor immune microenvironment (immune “cold” tumors). To overcome the obstacles, multifunctional carrier‐free nanoparticles (FCDP‐NPs) assembled from Fe 2+ , toll‐like receptor 9 agonist (CpG), cationic lipid (DOTAP) agent polydopamine are developed. After intratumoral injection, FCDP‐NPs carrying positive charge exposed under laser irradiation, which can capture tumor‐associated antigens (TAAs) generated upon post‐PTT form nanovaccines (FCD‐NPs@TAAs). The further promote cross‐presentation of TAAs, stimulate adaptive responses, shape “hot” tumors. As a result, improve survival rates elicit durable memory that remarkedly prevents metastasis, illustrating useful platform for PTT synergized immunotherapy.

Language: Английский

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In-situ vaccination immunotherapy of colorectal cancer with STING agonist-integrated supramolecular nanovectors

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102273 - 102273

Published: April 23, 2024

Language: Английский

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Nitroxide radical conjugated ovalbumin theranostic nanosystem for enhanced dendritic cell-based immunotherapy and T1-magnetic resonance imaging

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 547 - 563

Published: July 29, 2024

Language: Английский

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Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

We discuss the recent advances in nanomaterial design strategies for immunometabolic modulatory platforms and their applications targeting cancer-immunity cycle to enhance therapeutic outcomes.

Language: Английский

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In Silico-Guided Discovery of Polysaccharide Derivatives as Adjuvants in Nanoparticle Vaccines for Cancer Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Cancer vaccines utilizing nanoparticle (NP) structures that integrate antigens and adjuvants to enhance delivery stimulate immune responses are emerging as a promising avenue in cancer immunotherapy. However, the development of has been significantly hindered by low immunogenicity tumor antigens. To address this challenge, substantial efforts have made developing innovative elicit effective responses. In study, we develop NP vaccine assisted polysaccharide derivative adjuvant, designed through computational strategy, evoke antigen-specific antitumor immunity. Using TLR4 putative receptor, conducted comprehensive evaluation prescreening library consisting 34 inulin derivatives docking molecular dynamics simulation. Consequently, new derivative, benzoylated (InBz), is selected most agonist. The adjuvant effect InBz evaluated fabricating NPs encapsulating model antigen ovalbumin (OVA). vitro, InBz-OVA effectively activate signaling pathways facilitate dendritic cell maturation, thereby enhancing presentation. vivo, outperform commercial aluminum-based robust antibody titers, induce cytotoxic T lymphocytes, achieve significant suppression murine models. Besides, effects other representative derivatives, namely, acetylated chloroacetylated inulin, with moderate potential from library, also chemically synthesized experimentally found be agreement predictions, confirming credibility strategy. This study provides an platform for pursuit efficient polysaccharide-based adjuvants.

Language: Английский

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