Metal–Phenolic‐Mediated Assembly of Functional Small Molecules into Nanoparticles: Assembly and Bioapplications

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(12)

Опубликована: Янв. 29, 2024

Abstract Small molecules, including therapeutic drugs and tracer play a vital role in biological processing, disease treatment diagnosis, have inspired various nanobiotechnology approaches to realize their function, particularly drug delivery. Desirable features of delivery system for functional small molecules (FSMs) include high biocompatibility, loading capacity, simple manufacturing processes, without the need chemical modification FSM itself. Herein, we report versatile approach, based on metal–phenolic‐mediated assembly, assembling FSMs into nanoparticles (i.e., FSM‐MPN NPs) under aqueous ambient conditions. We demonstrate anticancer drugs, latency reversal agents, fluorophores at up ~80 % that is mostly facilitated by π hydrophobic interactions between nanoparticle components. Secondary engineering involving coating with polyphenol–antibody thin film or sequential co‐loading multiple enables cancer cell targeting combination delivery, respectively. Incorporating NPs visualization biodistribution different time points, revealing most these are retained kidney heart 24 h post intravenous administration. This work provides viable pathway rational design molecule platforms diverse applications.

Язык: Английский

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Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2024, Номер 64(1)

Опубликована: Авг. 22, 2024

Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic

Язык: Английский

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Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 4, 2024

Autoimmune disorders are characterized by aberrant T cell and B reactivity to the body's own components, resulting in tissue destruction organ dysfunction. diseases affect a wide range of people many parts world have become one major concerns public health. In recent years, there been substantial progress our understanding epidemiology, risk factors, pathogenesis mechanisms autoimmune diseases. Current approved therapeutic interventions for mainly non-specific immunomodulators may cause broad immunosuppression that leads serious adverse effects. To overcome limitations immunosuppressive drugs treating diseases, precise target-specific strategies urgently needed. date, significant advances made immune tolerance, offering new avenue developing antigen-specific immunotherapies These approaches shown great potential various preclinical animal models recently evaluated clinical trials. This review describes common manifestation with focus on typical including multiple sclerosis, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, sjögren's syndrome. We discuss current therapeutics developed this field, highlight use nanomaterials mRNA vaccine techniques induce tolerance.

Язык: Английский

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Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)

Опубликована: Май 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Язык: Английский

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The interaction between particles and vascular endothelium in blood flow

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 207, С. 115216 - 115216

Опубликована: Фев. 21, 2024

Язык: Английский

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Perspectives on Protein–Nanoparticle Interactions at the In Vivo Level

Langmuir, Год журнала: 2024, Номер 40(15), С. 7781 - 7790

Опубликована: Апрель 4, 2024

The distinct features of nanoparticles have provided a vast opportunity developing new diagnosis and therapy strategies for miscellaneous diseases. Although few nanomedicines are available in the market or translation stage, many important issues still unsolved. When entering body, nanomaterials will be quickly coated by proteins from their surroundings, forming corona on surface, so-called protein corona. Studies shown that has biological implications, particularly at vivo level. For example, they can promote immune system to rapidly clear these outer materials prevent playing designed role therapy. In this Perspective, techniques characterizing protein–nanoparticle interactions critically summarized. Effects nanoparticle properties environmental factors formation, which further regulate fate nanoparticles, highlighted discussed. Moreover, recent progress biomedical application corona-engineered is introduced, future directions yet challenging research area also briefly

Язык: Английский

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Liver cirrhosis: molecular mechanisms and therapeutic interventions

MedComm, Год журнала: 2024, Номер 5(10)

Опубликована: Сен. 17, 2024

Liver cirrhosis is the end-stage of chronic liver disease, characterized by inflammation, necrosis, advanced fibrosis, and regenerative nodule formation. Long-term inflammation can cause continuous damage to tissues hepatocytes, along with increased vascular tone portal hypertension. Among them, fibrosis necessary stage essential feature cirrhosis, effective antifibrosis strategies are commonly considered key treating cirrhosis. Although different therapeutic aimed at reversing or preventing have been developed, effects not be more satisfactory. In this review, we discussed abnormal changes in microenvironment that contribute progression highlighted importance recent strategies, including lifestyle improvement, small molecular agents, traditional Chinese medicine, stem cells, extracellular vesicles, gut remediation, regulate Meanwhile, for nanoparticles discussed, as their possible underlying broad application prospects ameliorating Finally, also reviewed major challenges opportunities nanomedicine‒biological environment interactions. We hope review will provide insights into pathogenesis mechanisms thus facilitating new methods, drug discovery, better treatment

Язык: Английский

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RNA nanotherapeutics for hepatocellular carcinoma treatment

Theranostics, Год журнала: 2024, Номер 15(3), С. 965 - 992

Опубликована: Дек. 2, 2024

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, particularly due to the limited effectiveness current therapeutic options for advanced-stage disease. The efficacy traditional treatments is often compromised by intricate liver microenvironment and inherent heterogeneity. RNA-based therapeutics offer promising alternative, utilizing innovative approach targeting aberrant molecular pathways modulating tumor microenvironment. integration nanotechnology in this field, through development advanced nanocarrier delivery systems, especially lipid nanoparticles (LNPs), polymer (PNPs), bioinspired vectors, enhances precision RNA therapies. This review highlights significant progress nanotherapeutics HCC treatment, covering micro (miRNA), small interfering (siRNA), message (mRNA), activating (saRNA) mediated gene silencing, protein restoration, activation, cancer vaccines, concurrent therapy. It further comprehensively discusses prevailing challenges within landscape provides forward-looking perspective on potential transform treatment.

Язык: Английский

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Selective induction of apoptotic cell death in lung carcinoma cells by curcumin-loaded PEGylated lipid nanoparticles with minimal normal tissue toxicity: in vitro and in vivo toxicity evaluation by oral delivery

Materials Advances, Год журнала: 2024, Номер 5(10), С. 4504 - 4523

Опубликована: Янв. 1, 2024

Selective induction of apoptotic cancer cell death by curcumin-loaded PEGylated lipid nanoparticles.

Язык: Английский

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Nebulized inhalation of nintedanib-loaded biomimetic nano-liposomes attenuated bleomycin-induced interstitial lung fibrosis in mice

Nano Today, Год журнала: 2024, Номер 56, С. 102298 - 102298

Опубликована: Май 8, 2024

Idiopathic pulmonary fibrosis (IPF) is an irreversible interstitial lung disease with a poor prognosis. However, there are currently few drugs available for its treatment. Nintedanib clinically effective but associated gastrointestinal adverse effects and weight loss. Due to drug intolerance, the overall outcomes of nintedanib therapy substantially compromised in quite patients. In present study, we synthesized nintedanib-loaded biomimetic liposomes (Nin-lipo) improve antifibrotic efficacy tolerance nintedanib. It was observed that nebulized inhalation small doses Nin-lipo (2 mg/kg) resulted greater delivery efficiency higher concentrations tissue than conventional oral (60 mg/kg). Furthermore, significantly inhibited bleomycin (BLM)-induced improved function mice. The possible molecular mechanism anti-fibrosis by investigated. found act mechanistically on alveolar macrophages via surfactant proteins A D (SP-A/D) simulating surfactants inhibiting polarization M2 macrophages. These thereby reduced secretion transforming growth factor 1 (TGF-β1) Moreover, demonstrated significant against loss liver abnormalities mouse model caused Therefore, could greatly while maintaining excellent safety profile. potentially be developed as new IPF.

Язык: Английский

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