Current Drug Delivery,
Год журнала:
2023,
Номер
21(10), С. 1285 - 1299
Опубликована: Ноя. 6, 2023
Abstract:
The
field
of
microfluidics
encompasses
the
study
fluid
behavior
within
micro-channels
and
development
miniature
systems
featuring
internal
compartments
or
passageways
tailored
for
control
manipulation.
Microfluidic
devices
capitalize
on
unique
chemical
physical
properties
exhibited
by
fluids
at
microscopic
scale.
In
contrast
to
their
larger
counterparts,
microfluidic
offer
a
multitude
advantages.
Their
implementation
facilitates
investigation
utilization
reduced
sample,
solvent,
reagent
volumes,
thus
yielding
decreased
operational
expenses.
Owing
compact
dimensions,
these
allow
concurrent
execution
multiple
procedures,
leading
expedited
experimental
timelines.
Over
past
two
decades,
has
undergone
remarkable
advancements,
evolving
into
multifaceted
discipline.
Subfields
such
as
organ-on-a-chip
paper-based
have
matured
distinct
fields
study.
Nonetheless,
while
scientific
progress
realm
been
notable,
its
translation
autonomous
end-user
applications
remains
frontier
be
fully
explored.
This
paper
sets
forth
central
objective
scrutinizing
present
research
paradigm,
prevailing
limitations,
potential
prospects
customizable
devices.
Our
inquiry
revolves
around
latest
strides
achieved,
constraints,
conceivable
trajectories
adaptable
technologies.
We
meticulously
delineate
existing
iterations
systems,
elucidate
principles,
deliberate
upon
encountered
provide
visionary
outlook
toward
future
trajectory
advancements.
summation,
this
work
endeavors
shed
light
current
state
underscore
operative
intricacies,
address
incumbent
challenges,
unveil
promising
pathways
that
chart
course
next
innovation.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(19)
Опубликована: Фев. 22, 2023
Abstract
Multicellular
spheroids
and
organoids
are
promising
in
vitro
3D
models
personalized
medicine
drug
screening.
They
replicate
the
structural
functional
characteristics
of
human
organs
vivo.
Microfluidic
technology
micro‐nano
fabrication
can
fulfill
high
requirement
engineering
approach
growing
research
interest
organoids.
In
this
review,
comparatively
introduced.
Then
it
is
illustrated
how
spheroids‐
organoids‐on‐a‐chip
facilitates
their
establishment,
expansion,
application
through
spatial‐temporal
control,
mechanical
cues
modeling,
high‐throughput
analysis,
co‐culture,
multi‐tissue
interactions,
biosensing,
bioimaging
integration.
The
potential
opportunities
challenges
developing
finally
outlooked.
Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2599 - 2599
Опубликована: Ноя. 7, 2023
Non-invasive
drug
delivery
across
the
blood–brain
barrier
(BBB)
represents
a
significant
advancement
in
treating
neurological
diseases.
The
BBB
is
tightly
packed
layer
of
endothelial
cells
that
shields
brain
from
harmful
substances
blood,
allowing
necessary
nutrients
to
pass
through.
It
highly
selective
barrier,
which
poses
challenge
delivering
therapeutic
agents
into
brain.
Several
non-invasive
procedures
and
devices
have
been
developed
or
are
currently
being
investigated
enhance
BBB.
This
paper
presents
review
prospective
analysis
art
science
address
pharmacology,
technology,
systems,
regulatory
approval,
ethical
concerns,
future
possibilities.
Nucleic
acid
therapeutics
represent
a
highly
promising
treatment
approach
in
modern
medicine,
treating
diseases
at
the
genetic
level.
However,
these
face
numerous
challenges
practical
applications,
particularly
regarding
their
stability,
effectiveness,
cellular
uptake
efficiency,
and
limitations
delivering
them
specifically
to
target
tissues.
To
overcome
obstacles,
researchers
have
developed
various
innovative
delivery
systems,
including
viral
vectors,
lipid
nanoparticles,
polymer
inorganic
protein
carriers,
exosomes,
antibody
oligonucleotide
conjugates,
DNA
nanostructure-based
systems.
These
systems
enhance
therapeutic
efficacy
of
nucleic
drugs
by
improving
targeting
specificity,
half-life
vivo.
In
this
review,
we
systematically
discuss
different
types
drugs,
analyze
major
barriers
encountered
delivery,
summarize
current
research
progress
emerging
We
also
highlight
latest
advancements
application
for
diseases,
infectious
cancer,
brain
wound
healing.
This
review
aims
provide
comprehensive
overview
drug
systems'
status
future
directions
integrating
nanotechnology,
biomaterials
science,
gene
editing
technologies,
emphasizing
transformative
potential
precision
medicine.
The Innovation,
Год журнала:
2023,
Номер
5(1), С. 100548 - 100548
Опубликована: Ноя. 27, 2023
•Micro/nanosystems
show
their
potential
to
address
the
challenges
of
precise
drug
delivery
brain.•Microfluidic
platforms
enable
creation
biomimetic
in
vitro
brain
models.•Micro/nano
materials
is
emerging
as
a
key
player
controllable
delivery.•The
minimally
invasive
fiberbot
microsystem
reduces
procedure's
invasiveness.•Image
tracking
micro/nanosystems
allows
for
controlled
therapeutic
interventions.
Drug
crucial
treatment
central
nervous
system
disorders.
While
significant
progress
has
been
made
recent
years,
there
are
still
major
achieving
brain.
Unmet
clinical
needs
arise
from
various
factors,
including
transport,
handling
large
doses,
methods
crossing
biological
barriers,
use
imaging
guidance,
and
effective
models
analyzing
delivery.
Recent
advances
have
shown
promise
addressing
some
these
challenges.
These
include
utilization
microfluidic
test
validate
process
setting,
development
novel
micro/nanocarriers
loads
across
blood-brain
barrier,
implementation
micro-intervention
systems
delivering
drugs
through
intraparenchymal
or
peripheral
routes.
In
this
article,
we
present
review
latest
developments
We
also
delve
into
relevant
diseases,
conventional
methods.
addition,
discuss
future
prospects
robotic
equipped
with
directed
transportation,
real-time
image
closed-loop
control.
Frontiers in Cellular Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Окт. 25, 2024
Neurovascular
unit
(NVU)
inflammation
via
activation
of
glial
cells
and
neuronal
damage
plays
a
critical
role
in
neurodegenerative
diseases.
Though
the
exact
mechanism
disease
pathogenesis
is
not
understood,
certain
biomarkers
provide
valuable
insight
into
pathogenesis,
severity,
progression
therapeutic
efficacy.
These
markers
can
be
used
to
assess
pathophysiological
status
brain
including
neurons,
astrocytes,
microglia,
oligodendrocytes,
specialized
microvascular
endothelial
cells,
pericytes,
NVU,
blood-brain
barrier
(BBB)
disruption.
Damage
or
derangements
tight
junction
(TJ),
adherens
(AdJ),
gap
(GJ)
components
BBB
lead
increased
permeability
neuroinflammation
various
disorders
disorders.
Thus,
neuroinflammatory
evaluated
blood,
cerebrospinal
fluid
(CSF),
tissues
determine
neurological
progression,
responsiveness.
Chronic
common
age-related
Alzheimer's
(AD),
Parkinson's
(PD),
dementia.
Neurotrauma/traumatic
injury
(TBI)
also
leads
acute
chronic
responses.
The
expression
some
may
altered
many
years
even
decades
before
onset
In
this
review,
we
discuss
neuroinflammation,
neurodegeneration
associated
with
disorders,
especially
those
neurovascular
pathologies.
CSF,
tissues.
Neurofilament
light
(NfL),
ubiquitin
C-terminal
hydrolase-L1
(UCHL1),
fibrillary
acidic
protein
(GFAP),
Ionized
calcium-binding
adaptor
molecule
1
(Iba-1),
transmembrane
119
(TMEM119),
aquaporin,
endothelin-1,
platelet-derived
growth
factor
receptor
beta
(PDGFRβ)
are
important
markers.
Recent
BBB-on-a-chip
modeling
offers
promising
potential
for
providing
an
in-depth
understanding
neurotherapeutics.
Integration
these
clinical
practice
could
potentially
enhance
early
diagnosis,
monitor
improve
outcomes.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 26, 2023
Brain
tumors
represent
the
leading
cause
of
disease-related
mortality
and
morbidity
in
children,
with
effective
treatments
urgently
required.
One
factor
limiting
effectiveness
systemic
therapy
is
blood-brain-barrier
(BBB),
which
limits
brain
penetration
many
anticancer
drugs.
BBB
integrity
often
compromised
tumors,
referred
to
as
blood-brain-tumor-barrier
(BBTB),
impact
a
BBTB
on
therapeutic
sensitivity
has
been
clearly
shown
for
few
selected
agents.
However,
heterogeneity
barrier
alteration
observed
within
single
tumor
across
distinct
pediatric
types
represents
an
additional
challenge.
Herein,
we
discuss
what
known
regarding
tumor-associated
vasculature
tumors.
We
innovative
complementary
preclinical
model
systems
that
will
facilitate
real-time
functional
analyses
all
types.
believe
broader
use
these
models
enable
us
develop
greater
understanding
processes
underlying
formation
ultimately
more
efficacious
treatment
options.
