Lab on a Chip, Год журнала: 2023, Номер 23(6), С. 1649 - 1663
Опубликована: Янв. 1, 2023
To improve our understanding of how the central nervous system functions, we report development an integrated chip for studying effects neurotransmitters on adult rat hippocampal progenitor cell neurospheroids.
Язык: Английский
Advanced Functional Materials, Год журнала: 2023, Номер 33(19)
Опубликована: Фев. 22, 2023
Abstract Multicellular spheroids and organoids are promising in vitro 3D models personalized medicine drug screening. They replicate the structural functional characteristics of human organs vivo. Microfluidic technology micro‐nano fabrication can fulfill high requirement engineering approach growing research interest organoids. In this review, comparatively introduced. Then it is illustrated how spheroids‐ organoids‐on‐a‐chip facilitates their establishment, expansion, application through spatial‐temporal control, mechanical cues modeling, high‐throughput analysis, co‐culture, multi‐tissue interactions, biosensing, bioimaging integration. The potential opportunities challenges developing finally outlooked.
Язык: Английский
Процитировано
76
Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2599 - 2599
Опубликована: Ноя. 7, 2023
Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is tightly packed layer of endothelial cells that shields brain from harmful substances blood, allowing necessary nutrients to pass through. It highly selective barrier, which poses challenge delivering therapeutic agents into brain. Several non-invasive procedures and devices have been developed or are currently being investigated enhance BBB. This paper presents review prospective analysis art science address pharmacology, technology, systems, regulatory approval, ethical concerns, future possibilities.
Язык: Английский
Процитировано
51
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Язык: Английский
Процитировано
4
Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2023, Номер 226, С. 115266 - 115266
Опубликована: Янв. 21, 2023
Язык: Английский
Процитировано
40
The Innovation, Год журнала: 2023, Номер 5(1), С. 100548 - 100548
Опубликована: Ноя. 27, 2023
•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.
Язык: Английский
Процитировано
37
Lab on a Chip, Год журнала: 2024, Номер 24(5), С. 1030 - 1063
Опубликована: Янв. 1, 2024
A great progress has been made in the development and use of lab-on-a-chip devices to model study blood–brain barrier (BBB) last decade.
Язык: Английский
Процитировано
12
Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Окт. 25, 2024
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism disease pathogenesis is not understood, certain biomarkers provide valuable insight into pathogenesis, severity, progression therapeutic efficacy. These markers can be used to assess pathophysiological status brain including neurons, astrocytes, microglia, oligodendrocytes, specialized microvascular endothelial cells, pericytes, NVU, blood-brain barrier (BBB) disruption. Damage or derangements tight junction (TJ), adherens (AdJ), gap (GJ) components BBB lead increased permeability neuroinflammation various disorders disorders. Thus, neuroinflammatory evaluated blood, cerebrospinal fluid (CSF), tissues determine neurological progression, responsiveness. Chronic common age-related Alzheimer's (AD), Parkinson's (PD), dementia. Neurotrauma/traumatic injury (TBI) also leads acute chronic responses. The expression some may altered many years even decades before onset In this review, we discuss neuroinflammation, neurodegeneration associated with disorders, especially those neurovascular pathologies. CSF, tissues. Neurofilament light (NfL), ubiquitin C-terminal hydrolase-L1 (UCHL1), fibrillary acidic protein (GFAP), Ionized calcium-binding adaptor molecule 1 (Iba-1), transmembrane 119 (TMEM119), aquaporin, endothelin-1, platelet-derived growth factor receptor beta (PDGFRβ) are important markers. Recent BBB-on-a-chip modeling offers promising potential for providing an in-depth understanding neurotherapeutics. Integration these clinical practice could potentially enhance early diagnosis, monitor improve outcomes.
Язык: Английский
Процитировано
8
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 197, С. 114842 - 114842
Опубликована: Апрель 25, 2023
Язык: Английский
Процитировано
16
Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102070 - 102070
Опубликована: Сен. 11, 2023
Язык: Английский
Процитировано
16
Frontiers in Oncology, Год журнала: 2023, Номер 13
Опубликована: Янв. 26, 2023
Brain tumors represent the leading cause of disease-related mortality and morbidity in children, with effective treatments urgently required. One factor limiting effectiveness systemic therapy is blood-brain-barrier (BBB), which limits brain penetration many anticancer drugs. BBB integrity often compromised tumors, referred to as blood-brain-tumor-barrier (BBTB), impact a BBTB on therapeutic sensitivity has been clearly shown for few selected agents. However, heterogeneity barrier alteration observed within single tumor across distinct pediatric types represents an additional challenge. Herein, we discuss what known regarding tumor-associated vasculature tumors. We innovative complementary preclinical model systems that will facilitate real-time functional analyses all types. believe broader use these models enable us develop greater understanding processes underlying formation ultimately more efficacious treatment options.
Язык: Английский
Процитировано
14