Targeted Cancer Therapy‐on‐A‐Chip DOI Creative Commons

Heba Abed,

R. Radha,

Shabana Anjum

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)

Опубликована: Авг. 5, 2024

Abstract Targeted cancer therapy (TCT) is gaining increased interest because it reduces the risks of adverse side effects by specifically treating tumor cells. TCT testing has traditionally been performed using two‐dimensional (2D) cell culture and animal studies. Organ‐on‐a‐chip (OoC) platforms have developed to recapitulate in vitro, as cancer‐on‐a‐chip (CoC), used for chemotherapeutics development testing. This review explores use CoCs both develop test TCTs, with a focus on three main aspects, identify target biomarkers development, free, un‐encapsulated encapsulated TCTs. Despite current challenges such system scaling, externally triggered TCToC shows promising future serve supportive, pre‐clinical platform expedite bench‐to‐bedside translation.

Язык: Английский

Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction DOI Creative Commons
Hairong Jin, Zengqi Xue, Jinnv Liu

и другие.

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Tissue damage and functional abnormalities in organs have become a considerable clinical challenge. Organoids are often applied as disease models drug discovery screening. Indeed, several studies shown that organoids an important strategy for achieving tissue repair biofunction reconstruction. In contrast to established stem cell therapies, high relevance. However, conventional approaches limited the application of regenerative medicine. Engineered might capacity overcome these challenges. Bioengineering—a multidisciplinary field applies engineering principles biomedicine—has bridged gap between medicine promote human health. More specifically, bioengineering been accelerate their translation. this review, beginning with basic concepts organoids, we describe strategies cultivating engineered discuss multiple modes create conditions breakthroughs organoid research. Subsequently, on reconstruction presented. Finally, highlight limitations challenges hindering utilization applications. Future research will focus using advanced tools personalized

Язык: Английский

Процитировано

15

Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Yusheng Zhang, Hong Wang, Yingpeng Sang

и другие.

MedComm, Год журнала: 2024, Номер 5(12)

Опубликована: Ноя. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Язык: Английский

Процитировано

14

Actuation for flexible and stretchable microdevices DOI Open Access

Uditha Roshan,

Amith Mudugamuwa, Haotian Cha

и другие.

Lab on a Chip, Год журнала: 2024, Номер 24(8), С. 2146 - 2175

Опубликована: Янв. 1, 2024

This review paper provides a comprehensive overview of the state-of-the-art actuation mechanisms for flexible and stretchable microdevices.

Язык: Английский

Процитировано

13

Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges DOI Creative Commons

Jiaoyue Cong,

Jin Wu, Yanjun Fang

и другие.

Environment International, Год журнала: 2024, Номер 188, С. 108744 - 108744

Опубликована: Май 11, 2024

Microplastic (MP) pollution has become a global environmental issue, and increasing concern been raised about its impact on human health. Current studies the toxic effects mechanisms of MPs have mostly conducted in animal models or vitro cell cultures, which limitations regarding inter-species differences stimulation cellular functions. Organoid technology derived from pluripotent adult stem cells broader prospects for predicting potential health risks to humans. Herein, we reviewed current application advancements opportunities different organoids, including brain, retinal, intestinal, liver, lung assess MPs. techniques accurately simulate complex processes reflect phenotypes related diseases caused by such as liver fibrosis, neurodegeneration, impaired intestinal barrier cardiac hypertrophy. Future perspectives were also proposed technological innovation risk assessment using extending lifespan organoids chronic toxicity MPs, reconstructing multi-organ interactions explore their studying microbiome-gut-brain axis effect

Язык: Английский

Процитировано

10

Biomaterials for inflammatory bowel disease: treatment, diagnosis and organoids DOI
Jia Wang, Yuying Shi,

Bei Mao

и другие.

Applied Materials Today, Год журнала: 2024, Номер 36, С. 102078 - 102078

Опубликована: Янв. 20, 2024

Язык: Английский

Процитировано

9

Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques DOI Creative Commons
Hui Wang, Xiangyang Li, Pengcheng Shi

и другие.

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101079 - 101079

Опубликована: Май 5, 2024

As a booming engineering technology, the microfluidic chip has been widely applied for replicating complexity of human intestinal micro-physiological ecosystems in vitro. Biosensors, 3D imaging, and multi-omics have to engineer more sophisticated barrier-on-chip platforms, allowing improved monitoring physiological processes enhancing performance. In this review, we report cutting-edge advances techniques establishment evaluation barrier platforms. We discuss different design principles microfabrication strategies gut models Further, comprehensively cover complex cell types (e.g., epithelium, organoids, endothelium, microbes, immune cells) controllable extracellular microenvironment parameters oxygen gradient, peristalsis, bioflow, gut-organ axis) used recapitulate main structural functional barriers. also present current multidisciplinary technologies indicators evaluating morphological structure integrity established Finally, highlight challenges future perspectives accelerating broader applications these platforms disease simulation, drug development, personalized medicine. Hence, review provides comprehensive guide development microfluidic-based

Язык: Английский

Процитировано

9

Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies DOI
Zongjie Wang, Shana O. Kelley

Nature Biomedical Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Язык: Английский

Процитировано

1

Organoid: Bridging the gap between basic research and clinical practice DOI
Guihu Weng, Jinxin Tao, Yueze Liu

и другие.

Cancer Letters, Год журнала: 2023, Номер 572, С. 216353 - 216353

Опубликована: Авг. 18, 2023

Язык: Английский

Процитировано

17

Advances in Human Organs-on-Chips and Applications for Drug Screening and Personalized Medicine DOI Creative Commons
Chenyang Zhou, Zhangjie Li, Kangyi Lu

и другие.

Fundamental Research, Год журнала: 2024, Номер unknown

Опубликована: Фев. 1, 2024

The limitations of conventional animal tests and two-dimensional cell culture hinder their advancement in fundamental research clinical/translational applications. As an emerging alternative technology, organ-on-a-chip serves as a platform that faithfully simulates the key phenotypical, physiological, functional features human tissues/organs through accurate regulation parameters such physical biochemical microenvironment, well cellular patterns. In this review, we mainly introduce recent progress field, including lung, gut, heart, liver, vasculature multiorgan studies. Furthermore, highlight potential applications drug screening personalized medicine. Finally, conclude by addressing current challenges future perspective technology commercialization organ-on-chips. We anticipate development will revolutionize studies on biology medicine providing new understanding mechanisms diseases insights into clinical therapeutics.

Язык: Английский

Процитировано

6

Complex in vitro models positioned for impact to drug testing in pharma: a review DOI Creative Commons
Michael S. Kang, Eugene C. Chen, Helen Cifuentes

и другие.

Biofabrication, Год журнала: 2024, Номер 16(4), С. 042006 - 042006

Опубликована: Авг. 27, 2024

Abstract Recent years have seen the creation and popularization of various complex in vitro models (CIVMs), such as organoids organs-on-chip, a technology with potential to reduce animal usage pharma while also enhancing our ability create safe efficacious drugs for patients. Public awareness CIVMs has increased, part, due recent passage FDA Modernization Act 2.0. This visibility is expected spur deeper investment adoption models. Thus, end-users model developers alike require framework both understand readiness current enter drug development process, assess upcoming same. review presents selection based on comparative -omics data (which we term model-omics), metrics qualification specific test assays that may support context-of-use (COU) assays. We surveyed existing healthy tissue ten development-critical organs body, provide evaluations suggestions improving model-omics COU each. In whole, this comes from perspective, seeks an evaluation where are poised maximum impact roadmap realizing potential.

Язык: Английский

Процитировано

6