Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(29)
Опубликована: Авг. 5, 2024
Abstract
Targeted
cancer
therapy
(TCT)
is
gaining
increased
interest
because
it
reduces
the
risks
of
adverse
side
effects
by
specifically
treating
tumor
cells.
TCT
testing
has
traditionally
been
performed
using
two‐dimensional
(2D)
cell
culture
and
animal
studies.
Organ‐on‐a‐chip
(OoC)
platforms
have
developed
to
recapitulate
in
vitro,
as
cancer‐on‐a‐chip
(CoC),
used
for
chemotherapeutics
development
testing.
This
review
explores
use
CoCs
both
develop
test
TCTs,
with
a
focus
on
three
main
aspects,
identify
target
biomarkers
development,
free,
un‐encapsulated
encapsulated
TCTs.
Despite
current
challenges
such
system
scaling,
externally
triggered
TCToC
shows
promising
future
serve
supportive,
pre‐clinical
platform
expedite
bench‐to‐bedside
translation.
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
Tissue
damage
and
functional
abnormalities
in
organs
have
become
a
considerable
clinical
challenge.
Organoids
are
often
applied
as
disease
models
drug
discovery
screening.
Indeed,
several
studies
shown
that
organoids
an
important
strategy
for
achieving
tissue
repair
biofunction
reconstruction.
In
contrast
to
established
stem
cell
therapies,
high
relevance.
However,
conventional
approaches
limited
the
application
of
regenerative
medicine.
Engineered
might
capacity
overcome
these
challenges.
Bioengineering—a
multidisciplinary
field
applies
engineering
principles
biomedicine—has
bridged
gap
between
medicine
promote
human
health.
More
specifically,
bioengineering
been
accelerate
their
translation.
this
review,
beginning
with
basic
concepts
organoids,
we
describe
strategies
cultivating
engineered
discuss
multiple
modes
create
conditions
breakthroughs
organoid
research.
Subsequently,
on
reconstruction
presented.
Finally,
highlight
limitations
challenges
hindering
utilization
applications.
Future
research
will
focus
using
advanced
tools
personalized
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Environment International,
Год журнала:
2024,
Номер
188, С. 108744 - 108744
Опубликована: Май 11, 2024
Microplastic
(MP)
pollution
has
become
a
global
environmental
issue,
and
increasing
concern
been
raised
about
its
impact
on
human
health.
Current
studies
the
toxic
effects
mechanisms
of
MPs
have
mostly
conducted
in
animal
models
or
vitro
cell
cultures,
which
limitations
regarding
inter-species
differences
stimulation
cellular
functions.
Organoid
technology
derived
from
pluripotent
adult
stem
cells
broader
prospects
for
predicting
potential
health
risks
to
humans.
Herein,
we
reviewed
current
application
advancements
opportunities
different
organoids,
including
brain,
retinal,
intestinal,
liver,
lung
assess
MPs.
techniques
accurately
simulate
complex
processes
reflect
phenotypes
related
diseases
caused
by
such
as
liver
fibrosis,
neurodegeneration,
impaired
intestinal
barrier
cardiac
hypertrophy.
Future
perspectives
were
also
proposed
technological
innovation
risk
assessment
using
extending
lifespan
organoids
chronic
toxicity
MPs,
reconstructing
multi-organ
interactions
explore
their
studying
microbiome-gut-brain
axis
effect
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101079 - 101079
Опубликована: Май 5, 2024
As
a
booming
engineering
technology,
the
microfluidic
chip
has
been
widely
applied
for
replicating
complexity
of
human
intestinal
micro-physiological
ecosystems
in
vitro.
Biosensors,
3D
imaging,
and
multi-omics
have
to
engineer
more
sophisticated
barrier-on-chip
platforms,
allowing
improved
monitoring
physiological
processes
enhancing
performance.
In
this
review,
we
report
cutting-edge
advances
techniques
establishment
evaluation
barrier
platforms.
We
discuss
different
design
principles
microfabrication
strategies
gut
models
Further,
comprehensively
cover
complex
cell
types
(e.g.,
epithelium,
organoids,
endothelium,
microbes,
immune
cells)
controllable
extracellular
microenvironment
parameters
oxygen
gradient,
peristalsis,
bioflow,
gut-organ
axis)
used
recapitulate
main
structural
functional
barriers.
also
present
current
multidisciplinary
technologies
indicators
evaluating
morphological
structure
integrity
established
Finally,
highlight
challenges
future
perspectives
accelerating
broader
applications
these
platforms
disease
simulation,
drug
development,
personalized
medicine.
Hence,
review
provides
comprehensive
guide
development
microfluidic-based
Fundamental Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 1, 2024
The
limitations
of
conventional
animal
tests
and
two-dimensional
cell
culture
hinder
their
advancement
in
fundamental
research
clinical/translational
applications.
As
an
emerging
alternative
technology,
organ-on-a-chip
serves
as
a
platform
that
faithfully
simulates
the
key
phenotypical,
physiological,
functional
features
human
tissues/organs
through
accurate
regulation
parameters
such
physical
biochemical
microenvironment,
well
cellular
patterns.
In
this
review,
we
mainly
introduce
recent
progress
field,
including
lung,
gut,
heart,
liver,
vasculature
multiorgan
studies.
Furthermore,
highlight
potential
applications
drug
screening
personalized
medicine.
Finally,
conclude
by
addressing
current
challenges
future
perspective
technology
commercialization
organ-on-chips.
We
anticipate
development
will
revolutionize
studies
on
biology
medicine
providing
new
understanding
mechanisms
diseases
insights
into
clinical
therapeutics.
Biofabrication,
Год журнала:
2024,
Номер
16(4), С. 042006 - 042006
Опубликована: Авг. 27, 2024
Abstract
Recent
years
have
seen
the
creation
and
popularization
of
various
complex
in
vitro
models
(CIVMs),
such
as
organoids
organs-on-chip,
a
technology
with
potential
to
reduce
animal
usage
pharma
while
also
enhancing
our
ability
create
safe
efficacious
drugs
for
patients.
Public
awareness
CIVMs
has
increased,
part,
due
recent
passage
FDA
Modernization
Act
2.0.
This
visibility
is
expected
spur
deeper
investment
adoption
models.
Thus,
end-users
model
developers
alike
require
framework
both
understand
readiness
current
enter
drug
development
process,
assess
upcoming
same.
review
presents
selection
based
on
comparative
-omics
data
(which
we
term
model-omics),
metrics
qualification
specific
test
assays
that
may
support
context-of-use
(COU)
assays.
We
surveyed
existing
healthy
tissue
ten
development-critical
organs
body,
provide
evaluations
suggestions
improving
model-omics
COU
each.
In
whole,
this
comes
from
perspective,
seeks
an
evaluation
where
are
poised
maximum
impact
roadmap
realizing
potential.
