Synthetic Methods for the formation of Heterocyclic Compounds from Oxime Ether Derivatives DOI Creative Commons

H. M. Mohan Kumari,

Himanshi Kumar,

Kamlesh Sharma

и другие.

IARS International Research Journal, Год журнала: 2022, Номер 12(02)

Опубликована: Авг. 29, 2022

Heterocyclic ring compounds are not only ubiquitous in prime diversity of vital natural products and synthetic pharmaceuticals thus highly important organic synthesis. They have an extensive range applications. mainly used as veterinary agrochemicals. also utilized corrosion inhibitors, sanitizers, antioxidants, dye stuff copolymers. accustomed source the synthesis bioactive compounds. Some like antibiotics such tetracyclines, cephalosporin, penicillin, aminoglycosides, alkaloids morphine, vinblastine, atropine, reserpine, tryptamine, reserpine etc. heterocyclic constituent. Hence, from new procedures been always demanding. Due to wide applications compounds, this study is a survey literature last one decade, describing methods for formation oxime ether.

Язык: Английский

Advances in pyrazolo[1,5-a]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment DOI Creative Commons

Terungwa H. Iorkula,

Osasere Jude-Kelly Osayawe,

Daniel A. Odogwu

и другие.

RSC Advances, Год журнала: 2025, Номер 15(5), С. 3756 - 3828

Опубликована: Янв. 1, 2025

Pyrazolo[1,5- a ]pyrimidines are notable class of heterocyclic compounds with potent protein kinase inhibitor (PKI) activity, playing critical role in targeted cancer therapy.

Язык: Английский

Процитировано

3
Rhodium‐Catalyzed Dual C−H Activation for Regioselective Triple Annulation of Enaminones: Access to Polycyclic Naphthopyran Derivatives DOI

V. Suresh,

Muniganti Naveen Kumar,

Attunuri Nagireddy

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(11), С. 1770 - 1776

Опубликована: Март 21, 2023

Abstract Rh‐catalyzed C−H activation of arenes for oxidative annulations with alkynes stands out as a protocol polycyclic scaffolds. This perspective drives us to disclose herein rhodium catalyzed regioselective triple annulation enaminones hydroxyl‐alkynoates via double functionalization naphtho‐pyran Secondary coordination OH in alkynoate dictated the regioselectivity. Initial lactonization occurred chemoselectively on enamine part carbo rhodation followed by reductive elimination. was scalable and has shown high functionality tolerance. KIE studies were done get insight mechanism, some downstream transformations achieved show synthetic potential method.

Язык: Английский

Процитировано

17
Pd-Catalyzed Sequential Electrophilic Cyclization/Selective C–H Annulation Cascade: Synthesis of Isoxazole-Phthalimide-Fused Poly-Heterocyclics DOI

V. Suresh,

T. Mahipal Reddy,

Dattatri

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(5), С. 3214 - 3225

Опубликована: Фев. 21, 2024

Harnessing the organo-palladium intermediates generated from electrophilic cyclizations for tandem C–C bond construction is a challenging task but constitutes an excellent tool constructing complex motifs simpler substrates. We realize herein such cyclative annulation of alkynyl-oxime ethers with maleimides facile isoxazole-phthalimide hybrid through Pd(II) catalysis. This protocol features regio-selectivity in C–H selection, broad substrate scope, good functional group tolerance, and scalability. Necessary KIE & labeling studies give insight into reaction mechanism.

Язык: Английский

Процитировано

6
Palladium‐Catalyzed Cyclization/Alkenylation of Ynone Oximes with Vinylsilanes for the Assembly of Isoxazolyl Vinylsilanes DOI
Jianxiao Li,

Chenjing Hong,

Yanan Niu

и другие.

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(6)

Опубликована: Янв. 15, 2024

Abstract A palladium‐catalyzed cascade cyclization/alkenylation for the assembly of synthetically valuable isoxazolyl vinylsilane derivative has been accomplished. Easily accessible ynone oximes, and available agents were used as reaction starting materials This protocol features broad substrate scope, good functional group tolerance, step‐ atom‐economy. Remarkably, this approach provides a new construction structurally diverse isoxazolyl‐containing vinylsilanes with high molecular complexity, showing promising application in synthetic pharmaceutical chemistry.

Язык: Английский

Процитировано

5
Indirect electrochemical reductive cyclization ofo-halophenylacrylamides mediated by phenanthrene DOI

Xue‐Qi Zhou,

Pei‐Bo Chen,

Qiang Xia

и другие.

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(8), С. 2039 - 2044

Опубликована: Янв. 1, 2023

We report a synthesis method for the selective 6- endo cyclization of o -phenylacrylamides to obtain 3,4-dihydroquinolinones via aryl anions formed by two-electron reduction under electrochemistry using phenanthrene as mediator.

Язык: Английский

Процитировано

11
Recent Advances in the Synthesis of Five‐membered Nitrogen Heterocycles Induced by Palladium Ions and Complexes DOI
Árpàd Molnár

ChemistrySelect, Год журнала: 2023, Номер 8(6)

Опубликована: Фев. 8, 2023

Abstract This review aims to collect and analyze recent results with respect the use of varied palladium preparations in synthesis five‐membered nitrogen heterocycles including condensed derivatives. Results have been selected focus on studies last three years. Furthermore, a common feature all methods treated here is that nitrogen‐containing ring formed via closing appropriate starting materials. Selected examples discussed will reveal plethora products from small monocycles multi‐ring systems can be successfully accessed. Major features are wide product ranges, high yields stereoselectivities often achieved under mild reaction conditions.

Язык: Английский

Процитировано

6
Palladium-Catalyzed Carbohalogenation of Olefins with Alkynyl Oxime Ethers: Rapid Access to Chlorine-Containing Isoxazoles DOI
Liren Zhang,

Chenjing Hong,

Junlong Tang

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(9), С. 6615 - 6625

Опубликована: Апрель 23, 2024

A palladium-catalyzed carbohalogenation of olefins with alkynyl oxime ethers has been described, which provides efficient and practical access to various chlorine-containing isoxazoles. This method exhibits excellent regioselectivity, good functional group compatibility, mild reaction conditions. The mechanistic studies suggest that the proceeds via a stabilized π-benzyl palladium intermediate, is essential for formation C(sp

Язык: Английский

Процитировано

2
Accessing Furan-Linked Methylene Oxindoles/Benzofurans via Stereoselective Palladium-Catalyzed Domino Cyclization/Cycloisomerization DOI

Yujie Yi,

Ye Yuan, Songsong Zhu

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(17), С. 12085 - 12093

Опубликована: Авг. 24, 2024

A palladium-catalyzed domino cyclization/cycloisomerization reaction of alkyne-tethered carbamoyl chlorides with (E)-β-chloroenones is reported. This proceeds via a syn-carbopalladation the alkyne, followed by vinyl-PdII-catalyzed cycloisomerization (E)-β-chloroenone cascade, which provides an efficient method to synthesize furan-linked methylene oxindoles. The features stereodefined vinyl-PdII species, high excellent 5-exo/6-endo selectivity, Z/E and sequential formation three bonds bis-heterocycles. strategy for synthesis furan-containing benzofurans has also been demonstrated.

Язык: Английский

Процитировано

2
Potassium Persulfate/Tributylamine-Mediated Alkylation/Annulation of N-Arylacrylamides with Alkyl Iodides DOI
Xiaoqing Li, Xiangsheng Xu, Huimin Chen

и другие.

Synlett, Год журнала: 2022, Номер 34(01), С. 63 - 66

Опубликована: Сен. 6, 2022

Abstract We report a catalyst-free method for the alkylation/annulation of N-arylacrylamides to give corresponding 3-alkyl-2-oxo-2,3-dihydro-1H-indoles by using alkyl iodides as precursors radicals. These reactions occur at moderate temperatures and are mediated easily accessible K2S2O8 Bu3N.

Язык: Английский

Процитировано

2
Synthetic Methods for the formation of Heterocyclic Compounds from Oxime Ether Derivatives DOI Creative Commons

H. M. Mohan Kumari,

Himanshi Kumar,

Kamlesh Sharma

и другие.

IARS International Research Journal, Год журнала: 2022, Номер 12(02)

Опубликована: Авг. 29, 2022

Heterocyclic ring compounds are not only ubiquitous in prime diversity of vital natural products and synthetic pharmaceuticals thus highly important organic synthesis. They have an extensive range applications. mainly used as veterinary agrochemicals. also utilized corrosion inhibitors, sanitizers, antioxidants, dye stuff copolymers. accustomed source the synthesis bioactive compounds. Some like antibiotics such tetracyclines, cephalosporin, penicillin, aminoglycosides, alkaloids morphine, vinblastine, atropine, reserpine, tryptamine, reserpine etc. heterocyclic constituent. Hence, from new procedures been always demanding. Due to wide applications compounds, this study is a survey literature last one decade, describing methods for formation oxime ether.

Язык: Английский

Процитировано

1