Journal of the Chinese Chemical Society,
Год журнала:
2022,
Номер
69(10), С. 1803 - 1809
Опубликована: Сен. 12, 2022
Abstract
Described
is
our
effort
toward
establishing
a
practical
and
sustainable
synthesis
of
bis(2‐hydroxy‐3,5‐di‐
t
‐butylphenyl)methanone.
In
it,
we
found
the
phenol‐aldehyde
condensation
could
be
efficiently
catalyzed
by
sulfonic
acid‐functionalized
microporous
carbon
spheres
(MCS‐SO
3
H).
Additionally,
developed
procedures
for
title
ligand
applying
readily
available
reagents
in
lieu
toxic
chromium
trioxide
fuming
boron
tribromide.
ACS Catalysis,
Год журнала:
2022,
Номер
12(16), С. 10499 - 10505
Опубликована: Авг. 10, 2022
The
alkylation
and
heteroarylation
of
unactivated
tertiary,
secondary,
primary
C(sp3)-H
bonds
was
achieved
by
employing
an
acridinium
photoredox
catalyst
along
with
readily
available
pyridine
Noxides
as
hydrogen
atom
transfer
(HAT)
precursors
under
visible
light.
Oxygen-centered
radicals,
generated
single-electron
oxidation
the
Noxides,
are
proposed
key
intermediates
whose
reactivity
can
be
easily
modified
structural
adjustments.
A
broad
range
aliphatic
C-H
substrates
electron-donating
or
-withdrawing
groups
well
various
olefinic
radical
acceptors
heteroarenes
were
tolerated.
Green Chemistry,
Год журнала:
2023,
Номер
25(13), С. 5206 - 5212
Опубликована: Янв. 1, 2023
We
have
developed
a
visible-light
induced
dehydrogenative
[4
+
2]
annulation
of
benzothioamides
and
alkynes
under
aerobic
conditions
to
synthesize
isothiochromenes.
Chemical Communications,
Год журнала:
2024,
Номер
60(56), С. 7228 - 7231
Опубликована: Янв. 1, 2024
A
visible-light-induced
K
2
S
O
8
-promoted
cascade
sulfonation/cyclization
reaction
to
afford
a
series
of
sulfonated
quinolino[2,1-
b
]quinazolinones
has
been
developed
under
mild
conditions.
Abstract
We
have
developed
a
Visible
Light
Promoted
Catalyst‐Free
(VLCF)
approach
to
synthesize
novel
conjugates
of
Isoniazid
and
Maleimide.
This
method
involves
the
formation
an
electron
donor‐acceptor
(EDA)
complex
between
isoniazid
maleimide
photochemical
activity
this
drives
transformation.
successfully
synthesized
Isoniazid‐Maleimide
derivatives
(3a–d)
at
gram
scale
under
visible
light
irradiation
without
additional
photo
catalyst
chromatographic
purification
resulting
in
excellent
yields
recyclable
green
solvent.
Molecular
docking
was
employed
predict
silico
anti‐tubercular
binding
modes
active
site
enoyl‐ACP
reductase,
InhA.
The
newly
compounds
exhibited
high
affinity
compared
Isoniazid‐NAD
adduct,
indicating
their
potential
for
more
effective
activity.
ADME
analysis
revealed
favourable
physicochemical
properties,
lipophilicity,
water
solubility,
pharmacokinetics,
drug‐likeness
compound
3a,
positioning
it
as
promising
candidate
further
drug
discovery
development.
Chinese Journal of Organic Chemistry,
Год журнала:
2024,
Номер
44(2), С. 398 - 398
Опубликована: Янв. 1, 2024
The
structure
of
3-sulfenyl
indoles
widely
exists
in
many
drug
molecules
and
natural
product
molecules.Its
derivatives
have
extensive
biological
activities
such
as
antibacterial,
antiviral
anti-tumor,
are
also
important
intermediates
organic
synthesis
structural
units
synthesis.Therefore,
indole
compounds
great
application
value
the
field
medicine.The
research
its
method
has
become
one
current
hotspots.In
this
paper,
progress
recent
years
is
reviewed,
some
reaction
mechanisms
discussed.
