Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(49)
Опубликована: Авг. 23, 2024
Abstract
Molecular
spherical
nucleic
acids
(m‐SNAs)
are
a
second
generation
of
(SNAs),
which
significance
in
potential
application
targeted
delivery
or
gene
regulation
due
to
their
defined
molecular
structures.
Nevertheless,
m‐SNAs
typically
involve
single
DNA
sequence
greatly
limits
its
functions
as
either
targeting
purpose
regulation.
In
response,
we
proposed
here
third
generation,
supramolecular
(Supra‐SNAs)
with
two
different
sequences
achieve
both
above‐mentioned
functions.
Specifically,
constructed
series
self‐assembly
structures
by
coupling
cell
membrane
receptor
(i.e.,
nucleolin)‐recognizing
aptamer
(AS1411)‐modified
adamantine
probe
and
human
epithelial
growth
factor
2
(HER2)
antisense‐functionalized
β‐cyclodextrin
specifically
inhibit
the
overexpression
HER2
proteins
for
regulations.
comparison
m‐SNA
precursors,
such
Supra‐SNA
exhibited
enhanced
levels
resistance
nuclease
degradation,
cellular
uptake,
capabilities
tumor
retention
capacity.
We
demonstrated
that
Supra‐SNAs
optimal
suppression
rates
apoptosis
via
phosphatidylinositol
3‐kinase/protein
kinase
B
signaling
pathway.
The
well‐defined
provide
an
attractive
platform
investigating
interrelationship
between
structure
property
at
level.
Chemical Science,
Год журнала:
2022,
Номер
14(4), С. 1010 - 1017
Опубликована: Дек. 28, 2022
Photothermal
therapy
(PTT)
has
emerged
as
one
of
the
important
strategies
for
cancer
treatment
due
to
its
precision
and
no
drug
resistance.
However,
upregulation
heat
shock
protein
(HSP)
expression
during
PTT
severely
limits
overall
therapeutic
effect.
Accordingly,
in
this
study,
we
developed
a
new
anticancer
strategy
based
on
an
l-glutathione
(GSH)-activated
prodrug
(Cy-S-S-Cbl),
which
consisted
alkylating
reagent
(Cbl)
covalently
linked
photothermal
photosensitizer
(Cy7),
achieve
cooperatively
enhanced
photothermal-chemotherapy.
In
presence
overexpressed
GSH
cells,
Cy-S-S-Cbl
was
converted
into
Cy-NH
Abstract
Photoacoustic
imaging
(PAI)
and
photothermal
therapy
(PTT)
conducted
over
the
near‐infrared‐II
(NIR‐II)
window
offer
benefits
of
noninvasiveness
deep
tissue
penetration.
This
necessitates
development
highly
effective
therapeutic
agents
with
NIR‐II
photoresponsivity.
Currently,
predominant
organic
diagnostic
used
in
PAI‐guided
PTT
are
conjugated
polymeric
materials.
However,
they
exhibit
a
low
vivo
clearance
rate
long‐term
biotoxicity,
limiting
their
clinical
translation.
In
this
study,
an
small
molecule
(CY‐1234)
absorption
nanoencapsulation
(CY‐1234
nanoparticles
(NPs))
for
is
reported.
Extended
π‐conjugation
achieved
by
introducing
donor–acceptor
units
at
both
ends
molecule.
Consequently,
CY‐1234
exhibits
maximum
peak
1234
nm
tetrahydrofuran.
Nanoaggregates
synthesized
via
F‐127
encapsulation.
They
excellent
conversion
efficiency
76.01%
upon
light
irradiation.
After
intravenous
injection
NPs
into
tumor‐bearing
mice,
strong
PA
signals
tumor
ablation
observed
under
1064
laser
preliminary
study
can
pave
way
small‐molecule
nanoformulations
future
applications.
Chemical Science,
Год журнала:
2023,
Номер
15(3), С. 940 - 952
Опубликована: Дек. 12, 2023
Non-AIE-type
molecular
photosensitizers
(PSs)
suffer
from
the
aggregation-caused-quenching
(ACQ)
effect
in
an
aqueous
medium
due
to
strong
hydrophobic
and
π-π
interactions
of
their
conjugated
planes,
which
significantly
hinders
enhancement
tumor
photodynamic
therapy
(PDT).
So
far,
some
ionic
PSs
have
been
reported
with
good
water-solubility,
though
ACQ
can
still
be
induced
a
biological
environment
rich
ions,
leading
unsatisfactory
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(49)
Опубликована: Авг. 23, 2024
Abstract
Molecular
spherical
nucleic
acids
(m‐SNAs)
are
a
second
generation
of
(SNAs),
which
significance
in
potential
application
targeted
delivery
or
gene
regulation
due
to
their
defined
molecular
structures.
Nevertheless,
m‐SNAs
typically
involve
single
DNA
sequence
greatly
limits
its
functions
as
either
targeting
purpose
regulation.
In
response,
we
proposed
here
third
generation,
supramolecular
(Supra‐SNAs)
with
two
different
sequences
achieve
both
above‐mentioned
functions.
Specifically,
constructed
series
self‐assembly
structures
by
coupling
cell
membrane
receptor
(i.e.,
nucleolin)‐recognizing
aptamer
(AS1411)‐modified
adamantine
probe
and
human
epithelial
growth
factor
2
(HER2)
antisense‐functionalized
β‐cyclodextrin
specifically
inhibit
the
overexpression
HER2
proteins
for
regulations.
comparison
m‐SNA
precursors,
such
Supra‐SNA
exhibited
enhanced
levels
resistance
nuclease
degradation,
cellular
uptake,
capabilities
tumor
retention
capacity.
We
demonstrated
that
Supra‐SNAs
optimal
suppression
rates
apoptosis
via
phosphatidylinositol
3‐kinase/protein
kinase
B
signaling
pathway.
The
well‐defined
provide
an
attractive
platform
investigating
interrelationship
between
structure
property
at
level.
