Phototherapy: progress, challenges, and opportunities
Science China Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Smart fluorogenic tools: From designing principles to visualization of multistep protein aggregation
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
535, С. 216625 - 216625
Опубликована: Март 19, 2025
Язык: Английский
Synthesis and performance research of an AIE molecule
Journal of Photochemistry and Photobiology A Chemistry,
Год журнала:
2025,
Номер
unknown, С. 116420 - 116420
Опубликована: Апрель 1, 2025
Язык: Английский
Electrochemiluminescence biosensor for the thyroid cancer biomarker miRNA-146b-5p detection using Zr-based metal-organic framework
Analytica Chimica Acta,
Год журнала:
2025,
Номер
unknown, С. 344025 - 344025
Опубликована: Апрель 1, 2025
Язык: Английский
A Diketopyrrolopyrrole‐Based All‐in‐One Nanoplatform for Self‐Reinforcing Mild Photothermal Therapy Cascade Immunotherapy for Tumors
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(27)
Опубликована: Июль 15, 2024
Abstract
Mild
photothermal
therapy
(PTT)
has
attracted
attention
for
effectively
avoiding
the
severe
side
effects
associated
with
high‐temperature
tumor
ablation.
However,
its
progress
is
hindered
by
limited
availability
of
high‐performance
agents
(PTAs)
and
thermoresistance
cancer
cells
induced
heat
shock
reactions.
Herein,
this
work
proposes
a
new
strategy
to
expand
library
organic
small‐molecule
PTAs
utilize
it
construct
multifunctional
nano‐theranostic
platform.
By
incorporating
additional
acceptors
appropriate
π‐bridges,
diketopyrrolopyrrole‐based
dye
BDB
developed,
which
exhibits
strong
absorption
bright
fluorescence
emission
in
near‐infrared
(NIR)
region.
Subsequently,
co‐coated
protein
(HSP)
inhibitor
tanespimycin
(17‐AAG)
using
functional
amphiphilic
polymers
DSPE‐Hyd‐PEG
2000
‐cRGD
form
an
all‐in‐one
nanoplatform
BAG
NPs.
As
result,
NPs
can
precisely
target
tissue,
guide
treatment
process
real‐time
through
NIR‐II
fluorescence/photoacoustic/photothermal
imaging,
release
17‐AAG
on
demand
enhance
mild
PTT.
Additionally,
PTT
been
demonstrated
induce
immunogenic
cell
death
(ICD)
activate
systemic
anti‐tumor
immune
response,
thereby
suppressing
both
primary
distant
tumors.
Overall,
study
presents
designed
precise
combined
immunotherapy
effective
treatment.
Язык: Английский
Aggregation-Induced Emission: Application in Diagnosis and Therapy of Hepatocellular Carcinoma
Biosensors and Bioelectronics,
Год журнала:
2024,
Номер
266, С. 116722 - 116722
Опубликована: Авг. 29, 2024
Язык: Английский
Supramolecular-platform-assisted selective recognition of uric acid with high sensitivity via microenvironment modulation of a self-assembled probe
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(38), С. 9545 - 9549
Опубликована: Янв. 1, 2024
A
supramolecular
platform
for
uric
acid
recognition
through
a
straightforward,
resourceful
technique
under
the
tolerable
physiological
level.
Язык: Английский
Cyano Positional Isomerism Strategy for Constructing Mitochondria-Targeted AIEgen with Type I Reactive Oxygen Species Generation Capability
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Based
on
the
cyano
positional
isomerism
strategy,
a
cationic
AIEgen
was
developed,
which
can
specifically
stain
mitochondria,
and
ablate
cancer
cells
through
potent
type
I
photodynamic
therapy
both
in
vitro
multicellular
tumor
spheroid
models.
Язык: Английский
Engineered Cell‐Derived Nanovesicles with CAR and PH20 for Enhanced Targeted Photodynamic Cancer Therapy and Tumor Microenvironment Modulation
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment,
but
its
clinical
use
limited
by
nontargeted
photosensitizers
(PS)
that
accumulate
in
normal
tissues,
causing
adverse
effects,
and
poor
penetration
tumor
tissues
due
to
the
dense
extracellular
matrix
(ECM).
Here
an
innovative
approach
presented
using
cell‐derived
nanovesicles
(CNVs)
engineered
with
chimeric
antigen
receptor
(CAR)
hyaluronidase
PH20
enhance
targeted
PDT.
The
CAR–PH20
CNVs,
loaded
photosensitizer
pheophorbide
(PheoA),
specifically
target
HER2‐expressing
cells
degrade
hyaluronic
acid
microenvironment
(TME),
improving
drug
distribution.
In
vitro
vivo
experiments
demonstrate
increased
reactive
oxygen
species
(ROS)
generation,
improved
retention,
enhanced
therapeutic
efficacy
compared
conventional
methods.
When
combined
laser
irradiation,
these
CNVs
induce
significant
cell
apoptosis
inhibit
growth
mouse
models,
while
minimizing
toxicity
tissues.
This
platform
offers
strategy
for
targeted,
TME‐modulating
PDT
efficacy,
reduced
side
marking
advance
nanodrug‐based
therapies.
Язык: Английский