Chemical Science,
Journal Year:
2023,
Volume and Issue:
15(3), P. 940 - 952
Published: Dec. 12, 2023
Non-AIE-type
molecular
photosensitizers
(PSs)
suffer
from
the
aggregation-caused-quenching
(ACQ)
effect
in
an
aqueous
medium
due
to
strong
hydrophobic
and
π-π
interactions
of
their
conjugated
planes,
which
significantly
hinders
enhancement
tumor
photodynamic
therapy
(PDT).
So
far,
some
ionic
PSs
have
been
reported
with
good
water-solubility,
though
ACQ
can
still
be
induced
a
biological
environment
rich
ions,
leading
unsatisfactory
Small,
Journal Year:
2023,
Volume and Issue:
20(17)
Published: Dec. 3, 2023
Abstract
Photoacoustic
imaging
(PAI)
and
photothermal
therapy
(PTT)
conducted
over
the
near‐infrared‐II
(NIR‐II)
window
offer
benefits
of
noninvasiveness
deep
tissue
penetration.
This
necessitates
development
highly
effective
therapeutic
agents
with
NIR‐II
photoresponsivity.
Currently,
predominant
organic
diagnostic
used
in
PAI‐guided
PTT
are
conjugated
polymeric
materials.
However,
they
exhibit
a
low
vivo
clearance
rate
long‐term
biotoxicity,
limiting
their
clinical
translation.
In
this
study,
an
small
molecule
(CY‐1234)
absorption
nanoencapsulation
(CY‐1234
nanoparticles
(NPs))
for
is
reported.
Extended
π‐conjugation
achieved
by
introducing
donor–acceptor
units
at
both
ends
molecule.
Consequently,
CY‐1234
exhibits
maximum
peak
1234
nm
tetrahydrofuran.
Nanoaggregates
synthesized
via
F‐127
encapsulation.
They
excellent
conversion
efficiency
76.01%
upon
light
irradiation.
After
intravenous
injection
NPs
into
tumor‐bearing
mice,
strong
PA
signals
tumor
ablation
observed
under
1064
laser
preliminary
study
can
pave
way
small‐molecule
nanoformulations
future
applications.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
14(4), P. 1010 - 1017
Published: Dec. 28, 2022
Photothermal
therapy
(PTT)
has
emerged
as
one
of
the
important
strategies
for
cancer
treatment
due
to
its
precision
and
no
drug
resistance.
However,
upregulation
heat
shock
protein
(HSP)
expression
during
PTT
severely
limits
overall
therapeutic
effect.
Accordingly,
in
this
study,
we
developed
a
new
anticancer
strategy
based
on
an
l-glutathione
(GSH)-activated
prodrug
(Cy-S-S-Cbl),
which
consisted
alkylating
reagent
(Cbl)
covalently
linked
photothermal
photosensitizer
(Cy7),
achieve
cooperatively
enhanced
photothermal-chemotherapy.
In
presence
overexpressed
GSH
cells,
Cy-S-S-Cbl
was
converted
into
Cy-NH
Chemical Science,
Journal Year:
2023,
Volume and Issue:
15(3), P. 940 - 952
Published: Dec. 12, 2023
Non-AIE-type
molecular
photosensitizers
(PSs)
suffer
from
the
aggregation-caused-quenching
(ACQ)
effect
in
an
aqueous
medium
due
to
strong
hydrophobic
and
π-π
interactions
of
their
conjugated
planes,
which
significantly
hinders
enhancement
tumor
photodynamic
therapy
(PDT).
So
far,
some
ionic
PSs
have
been
reported
with
good
water-solubility,
though
ACQ
can
still
be
induced
a
biological
environment
rich
ions,
leading
unsatisfactory
