Authorea (Authorea),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 13, 2023
Radiotherapy
is
a
mainstay
treatment
for
malignant
tumors
in
clinical.
However,
enhancing
radiation
damage
to
tumor
cells
meanwhile
sparing
normal
tissues
still
great
challenge
radiotherapy.
Nanomaterials
with
high
atomic
number
(Z)
values
are
promising
radiosensitizers
by
promoting
the
energy
deposition
irradiated
cells,
thus
therapeutic
ratio
of
In
this
review,
we
described
mechanisms
high-Z
element
and
systematically
summarized
recent
progress
on
metal-based
nanomaterials,
including
metal
nanoparticles,
metal-organic
frameworks
(MOFs)
other
high-Z-containing
nanomaterials.
Finally,
further
potential
challenges
field
were
discussed.
Abstract
The
precise
targeted
delivery
of
therapeutic
agents
to
deep
regions
the
brain
is
crucial
for
effective
treatment
various
neurological
diseases.
However,
achieving
this
goal
challenging
due
presence
blood‒brain
barrier
(BBB)
and
complex
anatomy
brain.
Here,
a
biomimetic
self‐propelled
nanomotor
with
cascade
targeting
capacity
developed
inflammatory
nanomotors
are
designed
asymmetric
structures
mesoporous
SiO
2
head
multiple
MnO
tentacles.
Macrophage
membrane
modification
endows
BBB
penetration
abilities
catalyze
degradation
H
O
into
,
not
only
by
reducing
inflammation
but
also
providing
driving
force
penetration.
Additionally,
loaded
curcumin,
which
actively
regulates
macrophage
polarization
from
M1
M2
phenotype.
All
in
vitro
cell,
organoid
model,
vivo
animal
experiments
confirmed
effectiveness
targeting,
penetration,
anti‐inflammatory,
nervous
system
function
maintenance.
Therefore,
study
introduces
platform
ability
active
Abstract
Cancer
cells
typically
display
redox
imbalance
compared
with
normal
due
to
increased
metabolic
rate,
accumulated
mitochondrial
dysfunction,
elevated
cell
signaling,
and
accelerated
peroxisomal
activities.
This
may
regulate
gene
expression,
alter
protein
stability,
modulate
existing
cellular
programs,
resulting
in
inefficient
treatment
modalities.
Therapeutic
strategies
targeting
intra‐
or
extracellular
states
of
cancer
at
varying
state
progression
trigger
programmed
death
if
exceeded
a
certain
threshold,
enabling
therapeutic
selectivity
overcoming
resistance
radiotherapy
chemotherapy.
Nanotechnology
provides
new
opportunities
for
modulating
their
excellent
designability
high
reactivity.
Various
nanomaterials
are
widely
researched
enhance
highly
reactive
substances
(free
radicals)
production,
disrupt
the
endogenous
antioxidant
defense
systems,
both.
Here,
physiological
features
described
challenges
illustrated.
Then,
that
classified
elaborated
upon
based
on
ability
target
regulations.
Finally,
future
perspectives
this
field
proposed.
It
is
hoped
review
guidance
design
nanomaterials‐based
approaches
involving
therapy,
especially
cancers
resistant
chemotherapy,
etc.
ACS Nano,
Год журнала:
2024,
Номер
18(21), С. 13910 - 13923
Опубликована: Май 16, 2024
Thanks
to
their
excellent
photoelectric
characteristics
generate
cytotoxic
reactive
oxygen
species
(ROS)
under
the
light-activation
process,
TiO2
nanomaterials
have
shown
significant
potential
in
photodynamic
therapy
(PDT)
for
solid
tumors.
Nevertheless,
limited
penetration
depth
of
TiO2-based
photosensitizers
and
excitation
sources
(UV/visible
light)
PDT
remains
a
formidable
challenge
when
confronted
with
complex
tumor
microenvironments
(TMEs).
Here,
we
present
H2O2-driven
black
mesoporous
nanomotor
near-infrared
(NIR)
light
absorption
capability
autonomous
navigation
ability,
which
effectively
enhances
NIR
light-triggered
PDT.
The
was
rationally
designed
fabricated
based
on
Janus
nanostructure,
consists
light-responsive
nanosphere
an
enzyme-modified
periodic
organosilica
(PMO)
nanorod
that
wraps
around
nanosphere.
overexpressed
H2O2
can
drive
TME
catalysis
catalase
PMO
domain.
By
precisely
controlling
ratio
compartments
TiO2&PMO
nanomotors
achieve
optimal
self-propulsive
directionality
velocity,
enhancing
cellular
uptake
facilitating
deep
penetration.
Additionally,
by
decomposition
endogenous
within
tumors,
these
continuously
supply
enable
highly
efficient
ROS
production
photocatalysis
TiO2,
leading
intensified
effects
effective
inhibition.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
Abstract
The
existence
of
the
blood–brain
barrier
(BBB)
and
characteristics
immunosuppressive
microenvironment
in
glioblastoma
(GBM)
present
significant
challenges
for
targeted
GBM
therapy.
To
address
this,
a
biomimetic
hybrid
cell
membrane‐modified
dual‐driven
heterojunction
nanomotor
(HM@MnO
2
‐AuNR‐SiO
)
is
proposed
treatment.
These
nanomotors
are
designed
to
bypass
BBB
target
glioma
regions
by
mimicking
surface
macrophage
membranes.
More
importantly,
MnO
structure
enables
propulsion
through
near‐infrared‐II
(NIR‐II)
light
oxygen
bubbles,
allowing
effective
treatment
at
deep
tumor
sites.
Meanwhile,
plasmonic
AuNR‐MnO
heterostructure
facilitates
separation
electron–hole
pairs
generates
reactive
species
(ROS),
inducing
immunogenic
death
under
NIR‐II
laser
irradiation.
Furthermore,
reacts
release
Mn
2+
ions,
activating
cGAS‐STING
pathway
enhancing
antitumor
immunity.
In
vitro
vivo
experiments
demonstrate
that
these
achieve
active
targeting
infiltration,
promoting
M1
polarization,
dendritic
maturation,
effector
T‐cell
activation,
thereby
catalysis
immunotherapy
ROS
production
STING
activation.
Abstract
The
tumour‐targeting
efficiency
of
systemically
delivered
chemodrugs
largely
dictates
the
therapeutic
outcome
anticancer
treatment.
Major
challenges
lie
in
complexity
diverse
biological
barriers
that
drug
delivery
systems
must
hierarchically
overcome
to
reach
their
cellular/subcellular
targets.
Herein,
an
“all‐in‐one”
red
blood
cell
(RBC)‐derived
microrobot
can
adapt
five
critical
stages
during
systemic
delivery,
is,
circulation,
accumulation,
release,
extravasation,
and
penetration,
is
developed.
microrobots
behave
like
natural
RBCs
due
almost
identical
surface
properties,
but
be
magnetically
manipulated
accumulate
at
regions
interest
such
as
tumours.
Next,
are
“immolated”
under
laser
irradiation
release
cargoes
and,
by
generating
heat,
enhance
extravasation
through
vascular
barriers.
As
a
coloaded
agent,
pirfenidone
(PFD)
inhibit
formation
extracellular
matrix
increase
penetration
depth
solid
tumour.
It
demonstrated
this
system
effectively
suppresses
both
primary
metastatic
tumours
mouse
models
without
evident
side
effects,
may
represent
new
class
intelligent
biomimicking
robots
for
biomedical
applications.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(3), С. 3019 - 3030
Опубликована: Янв. 13, 2024
Urease-powered
nano/micromotors
can
move
at
physiological
urea
concentrations,
making
them
useful
for
biomedical
applications,
such
as
treating
bladder
cancer.
However,
their
movement
in
biological
environments
is
still
challenging.
Herein,
Janus
micromotors
based
on
black
TiO2
with
urease
asymmetric
catalytic
coating
were
designed
to
take
benefit
of
the
optical
properties
under
near-infrared
light
and
capability
simulated
(urea).
The
microspheres
half-coated
a
thin
layer
Au,
l-Cysteine
was
utilized
attach
enzyme
Au
surface
using
its
thiol
group.
Biocatalytic
hydrolysis
through
biologically
relevant
concentrations
provided
driving
force
micromotors.
A
variety
parameters,
fuel
concentration,
viscosity,
ionic
character
environment,
used
investigate
how
moved
different
water,
PBS,
NaCl,
urine.
results
indicate
that
are
propelled
self-diffusiophoresis
caused
by
enzymatic
catalysis.
Due
low
toxicity
vitro
anticancer
effect,
effective
agents
photothermal
therapy,
which
help
kill
cancer
cells.
These
promising
suggest
biocompatible
hold
great
potential
improving
treatment
facilitating
diagnosis.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Abstract
During
fractionated
radiotherapy,
DNA
damage
repair
intensifies
in
tumor
cells,
culminating
cancer
radioresistance
and
subsequent
radiotherapy
failure.
Despite
the
recent
development
of
nanoradiosensitizers
targeting
specific
pathways,
persistence
mechanisms
involving
multiple
pathways
remains
inevitable.
To
address
this
challenge,
a
nucleophilicity‐engineered
ligation
blockade
nanoradiosensitizer
(DLBN)
comprising
Au/CeO
2
heteronanostructure
modified
with
trans‐acting
activator
transcription
peptides
is
reported,
which
targets
inhibits
inside
cell
nuclei
via
heterointerface‐mediated
dephosphorylation
DNA,
crucial
step
overcoming
radioresistance.
First,
Schottky‐type
nucleus‐targeting
DLBN
effectively
radiation‐induced
catalase‐mimetic
activity
radiation‐triggered
catalytic
reactions.
Notably,
by
leveraging
heterointerface,
spontaneously
dissociates
H
O
to
hydroxide,
nucleophile
higher
nucleophilicity,
thereby
exhibiting
remarkable
capability
at
nicks
through
facilitated
nucleophilic
attack.
This
enables
ligation,
pivotal
all
interrupting
process.
Consequently,
resensitizes
radioresistant
cells
therapy‐induced
radioresistance,
leading
substantial
accumulation
unrepaired
damage.
These
findings
offer
insight
into
within
nuclei,
underscore
potential
heteronanostructure‐based
block
against
Langmuir,
Год журнала:
2023,
Номер
39(11), С. 4037 - 4048
Опубликована: Март 13, 2023
By
directly
harming
cancer
cells,
radiotherapy
(RT)
is
a
crucial
therapeutic
approach
for
the
treatment
of
cancers.
However,
efficacy
RT
reduced
by
limited
accumulation
and
short
retention
time
radiosensitizer
in
tumor.
Herein,
we
developed
hypoxia-triggered
situ
aggregation
nanogapped
gold
nanospheres
(AuNNP@PAA/NIC
NPs)
within
tumor,
resulting
second
near-infrared
window
(NIR-II)
photoacoustic
(PA)
imaging
enhanced
radiosensitization.
AuNNP@PAA/NIC
NPs
demonstrated
increased
hypoxic
tumors,
mainly
due
to
aggregation.
After
NPs,
absorption
system
extended
from
visible
light
NIR-II
owing
plasmon
coupling
effects
between
adjacent
nanoparticles.
Compared
normoxic
PA
intensity
at
1200
nm
tumor
0.42
1.88
24
h
postintravenous
injection
leading
an
increase
4.5
times.
This
indicated
that
microenvironment
successfully
triggered
NPs.
The
vivo
radiotherapeutic
effect
this
radiosensitizers
significantly
radiosensitization
thus
resulted
superior
outcomes.
