Biomimetic Self‐Propelled Asymmetric Nanomotors for Cascade‐Targeted Treatment of Neurological Inflammation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: March 9, 2024

Abstract The precise targeted delivery of therapeutic agents to deep regions the brain is crucial for effective treatment various neurological diseases. However, achieving this goal challenging due presence blood‒brain barrier (BBB) and complex anatomy brain. Here, a biomimetic self‐propelled nanomotor with cascade targeting capacity developed inflammatory nanomotors are designed asymmetric structures mesoporous SiO 2 head multiple MnO tentacles. Macrophage membrane modification endows BBB penetration abilities catalyze degradation H O into , not only by reducing inflammation but also providing driving force penetration. Additionally, loaded curcumin, which actively regulates macrophage polarization from M1 M2 phenotype. All in vitro cell, organoid model, vivo animal experiments confirmed effectiveness targeting, penetration, anti‐inflammatory, nervous system function maintenance. Therefore, study introduces platform ability active

Language: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

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Black Titania Janus Mesoporous Nanomotor for Enhanced Tumor Penetration and Near-Infrared Light-Triggered Photodynamic Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(21), P. 13910 - 13923

Published: May 16, 2024

Thanks to their excellent photoelectric characteristics generate cytotoxic reactive oxygen species (ROS) under the light-activation process, TiO2 nanomaterials have shown significant potential in photodynamic therapy (PDT) for solid tumors. Nevertheless, limited penetration depth of TiO2-based photosensitizers and excitation sources (UV/visible light) PDT remains a formidable challenge when confronted with complex tumor microenvironments (TMEs). Here, we present H2O2-driven black mesoporous nanomotor near-infrared (NIR) light absorption capability autonomous navigation ability, which effectively enhances NIR light-triggered PDT. The was rationally designed fabricated based on Janus nanostructure, consists light-responsive nanosphere an enzyme-modified periodic organosilica (PMO) nanorod that wraps around nanosphere. overexpressed H2O2 can drive TME catalysis catalase PMO domain. By precisely controlling ratio compartments TiO2&PMO nanomotors achieve optimal self-propulsive directionality velocity, enhancing cellular uptake facilitating deep penetration. Additionally, by decomposition endogenous within tumors, these continuously supply enable highly efficient ROS production photocatalysis TiO2, leading intensified effects effective inhibition.

Language: Английский

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Intelligent micro/nanomotors: Fabrication, propulsion, and biomedical applications

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102212 - 102212

Published: Feb. 26, 2024

Language: Английский

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Glutathione and transglutaminase responsive janus gold nanorods for photoacoustic imaging-guided radiotherapy and chemodynamic therapy of tumors

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 751 - 759

Published: Feb. 18, 2025

Language: Английский

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A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Dec. 10, 2023

Abstract The tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome anticancer treatment. Major challenges lie in complexity diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an “all‐in‐one” red blood cell (RBC)‐derived microrobot can adapt five critical stages during systemic delivery, is, circulation, accumulation, release, extravasation, and penetration, is developed. microrobots behave like natural RBCs due almost identical surface properties, but be magnetically manipulated accumulate at regions interest such as tumours. Next, are “immolated” under laser irradiation release cargoes and, by generating heat, enhance extravasation through vascular barriers. As a coloaded agent, pirfenidone (PFD) inhibit formation extracellular matrix increase penetration depth solid tumour. It demonstrated this system effectively suppresses both primary metastatic tumours mouse models without evident side effects, may represent new class intelligent biomimicking robots for biomedical applications.

Language: Английский

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Urease-Powered Black TiO₂ Micromotors for Photothermal Therapy of Bladder Cancer

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(3), P. 3019 - 3030

Published: Jan. 13, 2024

Urease-powered nano/micromotors can move at physiological urea concentrations, making them useful for biomedical applications, such as treating bladder cancer. However, their movement in biological environments is still challenging. Herein, Janus micromotors based on black TiO2 with urease asymmetric catalytic coating were designed to take benefit of the optical properties under near-infrared light and capability simulated (urea). The microspheres half-coated a thin layer Au, l-Cysteine was utilized attach enzyme Au surface using its thiol group. Biocatalytic hydrolysis through biologically relevant concentrations provided driving force micromotors. A variety parameters, fuel concentration, viscosity, ionic character environment, used investigate how moved different water, PBS, NaCl, urine. results indicate that are propelled self-diffusiophoresis caused by enzymatic catalysis. Due low toxicity vitro anticancer effect, effective agents photothermal therapy, which help kill cancer cells. These promising suggest biocompatible hold great potential improving treatment facilitating diagnosis.

Language: Английский

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Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Language: Английский

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A Nucleophilicity‐Engineered DNA Ligation Blockade Nanoradiosensitizer Induces Irreversible DNA Damage to Overcome Cancer Radioresistance

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract During fractionated radiotherapy, DNA damage repair intensifies in tumor cells, culminating cancer radioresistance and subsequent radiotherapy failure. Despite the recent development of nanoradiosensitizers targeting specific pathways, persistence mechanisms involving multiple pathways remains inevitable. To address this challenge, a nucleophilicity‐engineered ligation blockade nanoradiosensitizer (DLBN) comprising Au/CeO 2 heteronanostructure modified with trans‐acting activator transcription peptides is reported, which targets inhibits inside cell nuclei via heterointerface‐mediated dephosphorylation DNA, crucial step overcoming radioresistance. First, Schottky‐type nucleus‐targeting DLBN effectively radiation‐induced catalase‐mimetic activity radiation‐triggered catalytic reactions. Notably, by leveraging heterointerface, spontaneously dissociates H O to hydroxide, nucleophile higher nucleophilicity, thereby exhibiting remarkable capability at nicks through facilitated nucleophilic attack. This enables ligation, pivotal all interrupting process. Consequently, resensitizes radioresistant cells therapy‐induced radioresistance, leading substantial accumulation unrepaired damage. These findings offer insight into within nuclei, underscore potential heteronanostructure‐based block against

Language: Английский

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Micro/Nanorobots for Advanced Light‐Based Biosensing and Imaging

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 6, 2024

Abstract Sensing and imaging of biomolecules are crucial to disease diagnosis, prognosis, therapy where optical techniques have essential utility. Untethered remotely controlled micro/nanorobots shown promising sensing capabilities, especially in complex biological environments. In this review, how used for biosensing while highlighting the significant developments field is discussed. Starting done by exploring colorimetric methods enabled micro/nanorobots. Significant advancements surface‐enhanced Raman spectroscopy‐integrated reviewed. Further, state‐of‐the‐art bio‐imaging applications at vitro intracellular level highlighted. Novel vivo assisted micro/nanorobot sensors examined. Furthermore, innovations assessed motion augmentation as a detection mechanism, with point‐of‐care molecular diagnostics. Finally, challenges associated micro/nanorobots‐assisted advanced discussing insights about potential research directions rapidly progressing summarized.

Language: Английский

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