Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(24)
Опубликована: Май 11, 2023
Abstract
Fluorescence
imaging
(FLI),
a
non‐invasive,
real‐time,
and
highly
sensitive
modality,
allows
for
investigating
the
molecular/cellular
level
activities
to
understand
physiological
functions
diseases.
The
emergence
of
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
has
endowed
fluorescence
with
deeper
tissue
penetration
unprecedented
clarity.
Among
various
NIR‐II
fluorophores,
organic
fluorescent
probes
have
occupied
pivotal
position
in
bioimaging
due
their
higher
biocompatibility,
safety,
potential
clinical
applications
compared
those
inorganic
probes.
To
obtain
high‐quality
dyes,
diverse
strategies
been
taken.
In
this
review,
different
optimizing
fluorophores
are
summarized,
including
traditional
chemical
modifications,
emerging
bioengineering
operations,
which
not
previously
elaborated
on
summarized.
Moreover,
highlighted
using
endogenous
serum
proteins
even
exogenous
gene‐editing
proteins,
would
provide
fresh
insights
design
good‐performance
dyes
help
develop
translation
future.
A
critical
perspective
direction
disease
is
also
proposed.
Abstract
Near‐infrared
(NIR)‐II
fluorescence
imaging‐guided
photothermal
therapy
(PTT)
has
attracted
great
research
interest,
and
constructing
donor‐acceptor
(D‐A)
electronic
configurations
become
an
established
approach
to
lower
bandgap
realize
NIR‐II
emission.
However,
very
few
π‐conjugated
phototheranostic
agents
can
efficient
guided
PTT
using
a
clinically
safe
laser
power
density,
implying
that
sufficient
performance
is
still
desired.
In
addition
the
continuously
refreshed
conversion
efficiency
levels,
strategies
focus
on
enhancing
light
absorptivity
have
been
rarely
discussed
endow
new
direction
for
PTT.
Herein,
dimerization
π‐extension
strategy
raised
synthesize
dimers
with
A‐D‐A
monomers.
We
observe
(ε)
of
strengthened
three
times
owing
enhanced
coupling
effect
as
result
π‐conjugation
extension,
thereby
surpassing
2‐fold
increase
in
chromophore
numbers
from
monomer
dimers.
Thanks
enhancement
absorption,
could
generate
much
more
heat
than
vivo
treatments.
Therefore,
anti‐tumor
outcome
fulfilled
by
under
low
(0.3
W/cm
2
).
Moreover,
extended
structures
favorable
radiative
excited
state
decay,
thus
exhibiting
distinguishing
improvement
imaging
compared
monomer.
Collectively,
due
improved
absorptivity,
gain
superior
brightness
over
recently
reported
material,
which
goes
beyond
double
doses
applications.
All
these
results
prove
effective
designing
high‐performance
materials.
Chemical Science,
Год журнала:
2024,
Номер
15(18), С. 6777 - 6788
Опубликована: Янв. 1, 2024
Designing
molecules
with
donor-acceptor-donor
(D-A-D)
architecture
plays
an
important
role
in
obtaining
second
near-infrared
region
(NIR-II,
1000-1700
nm)
fluorescent
dyes
for
biomedical
applications;
however,
this
always
comes
a
challenge
due
to
very
limited
electronic
acceptors.
On
the
other
hand,
endow
NIR-II
combined
therapeutic
applications,
trivial
molecular
design
is
indispensable.
Herein,
we
propose
pyrazine-based
planar
acceptor
strong
electron
affinity,
which
can
be
used
develop
dyes.
By
structurally
attaching
two
classical
triphenylamine
donors
it,
basic
D-A-D
module,
namely
Py-NIR,
generated.
The
planarity
of
crucial
induce
distinct
emission
peaking
at
∼1100
nm.
unique
construction
cause
twisted
and
flexible
conformation
by
repulsive
effect
between
donors,
essential
aggregation-induced
(AIE)
property.
tuned
intramolecular
motions
D-A
pair
brought
lead
remarkable
photothermal
conversion
efficiency
56.1%
type
I
photosensitization
favorable
hydroxyl
radical
(OH˙)
formation.
Note
that
no
additional
measures
are
adopted
design,
providing
ideal
platform
realize
probes
synergetic
functions
based
on
such
acceptor.
Besides,
nanoparticles
Py-NIR
exhibit
excellent
fluorescence
imaging
towards
orthotopic
4T1
breast
tumors
living
mice
high
sensitivity
contrast.
Combined
photoacoustic
caused
thermal
effect,
imaging-guided
photoablation
well
performed.
Our
work
has
created
new
opportunity
accelerating
applications.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(29)
Опубликована: Май 8, 2024
Abstract
Fluorescent
imaging
and
biosensing
in
the
near‐infrared‐II
(NIR‐II)
window
holds
great
promise
for
non‐invasive,
radiation‐free,
rapid‐response
clinical
diagnosis.
However,
it's
still
challenging
to
develop
bright
NIR‐II
fluorophores.
In
this
study,
we
report
a
new
strategy
enhance
brightness
of
aggregation‐induced
emission
(AIE)
fluorophores
through
intramolecular
electrostatic
locking.
By
introducing
sulfur
atoms
into
side
chains
thiophene
bridge
TSEH
molecule,
molecular
motion
conjugated
backbone
can
be
locked
interactions
between
nitrogen
atoms.
This
leads
enhanced
fluorescent
both
solution
aggregation
states.
Notably,
encapsulated
nanoparticles
(NPs)
show
brightness,
which
is
2.6‐fold
higher
than
TEH
NPs
with
alkyl
chains.
The
vivo
experiments
reveal
feasibility
vascular
tumor
high
signal‐to‐background
ratio
precise
resection
tiny
tumors.
addition,
polystyrene
nanospheres
are
utilized
antigen
detection
lateral
flow
assays,
showing
signal‐to‐noise
1.9‐fold
counterpart
detecting
low‐concentration
antigens.
work
highlights
potential
developing
locking
their
applications
diagnosis
biomedical
research.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(23)
Опубликована: Апрель 2, 2024
We
present
herein
the
synthesis
of
novel
pseudo-metalla-carbaporphyrinoid
species
(1M:
M=Pd
and
Pt)
achieved
through
inner
coordination
palladium(II)
platinum(II)
with
an
acyclic
N-confused
tetrapyrrin
analogue.
Despite
their
tetrapyrrole
frameworks
being
small,
akin
to
well-known
porphyrins,
these
exhibit
unusually
narrow
HOMO-LUMO
gap,
resulting
in
unprecedentedly
low-energy
absorption
second
near-infrared
(NIR-II)
region.
Density
functional
theory
(DFT)
calculations
revealed
unique
d
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(5)
Опубликована: Ноя. 9, 2022
Large
π-conjugated
systems
are
key
in
the
area
of
molecular
materials.
Herein,
we
prepare
via
AuI
-catalyzed
cyclization
a
series
fully
anthracene-fused
oligo-BODIPYs.
Their
structural
and
optoelectronic
properties
were
studied
by
several
techniques,
ranging
from
X-ray,
UV/Vis,
cyclic
voltammetry
to
transient
absorption
spectroscopy.
As
complement,
their
electronic
structures
explored
means
Density
Functional
Theory
(DFT)
calculations.
Depending
on
size
shape
skeleton,
unique
features-such
as
face-to-face
supramolecular
organization,
NIR
fluorescence
well
strong
electron
accepting
character-were
noted.
All
all,
aforementioned
features
render
them
valuable
for
technological
applications.
Chemical & Biomedical Imaging,
Год журнала:
2023,
Номер
1(9), С. 767 - 784
Опубликована: Март 30, 2023
Intracellular
biosynthetic
nanomaterials
offer
tremendous
opportunities
for
chemical
biomedical
imaging.
A
wide
range
of
biologically
active
tissues
are
available
biosynthesis,
including
cells,
bacteria,
plants,
and
viruses.
Nanomaterials
synthesized
by
intracellular
biomineralization
with
outstanding
biosafety
optical
properties
attract
unique
attention.
Herein,
an
overview
tunable
within
biological
imaging
is
presented.
The
synthetic
mechanisms
nanostructures
summarized
from
the
perspective
different
organisms.
ability
biosynthesis
commonly
used
green
synthesis
metal
nanoparticles
compared
to
those
physical
or
methods.
characteristics
these
make
it
possible
utilize
them
as
fluorescence
imaging,
surface-enhanced
Raman
spectral
mapping,
nuclear
magnetic
resonance
other
photonics
tools.
Importantly,
current
issues,
insights,
future
tendencies
development
presented
based
on
This
paper
provides
summary
a
critical
assessment
potential
applications
in
this
emerging
field,
laying
foundation
studies.
