Mitochondria-targetable small molecule fluorescent probes for the detection of cancer-associated biomarkers: A review

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1289, P. 342060 - 342060

Published: Nov. 25, 2023

Language: Английский

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Orchestrated Strategies for Developing Fluorophores for NIR‐II Imaging

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(24)

Published: May 11, 2023

Abstract Fluorescence imaging (FLI), a non‐invasive, real‐time, and highly sensitive modality, allows for investigating the molecular/cellular level activities to understand physiological functions diseases. The emergence of second near‐infrared window (NIR‐II, 1000–1700 nm) has endowed fluorescence with deeper tissue penetration unprecedented clarity. Among various NIR‐II fluorophores, organic fluorescent probes have occupied pivotal position in bioimaging due their higher biocompatibility, safety, potential clinical applications compared those inorganic probes. To obtain high‐quality dyes, diverse strategies been taken. In this review, different optimizing fluorophores are summarized, including traditional chemical modifications, emerging bioengineering operations, which not previously elaborated on summarized. Moreover, highlighted using endogenous serum proteins even exogenous gene‐editing proteins, would provide fresh insights design good‐performance dyes help develop translation future. A critical perspective direction disease is also proposed.

Language: Английский

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Dimerization extends π‐conjugation of electron donor‐acceptor structures leading to phototheranostic properties beyond the sum of two monomers

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Feb. 22, 2024

Abstract Near‐infrared (NIR)‐II fluorescence imaging‐guided photothermal therapy (PTT) has attracted great research interest, and constructing donor‐acceptor (D‐A) electronic configurations become an established approach to lower bandgap realize NIR‐II emission. However, very few π‐conjugated phototheranostic agents can efficient guided PTT using a clinically safe laser power density, implying that sufficient performance is still desired. In addition the continuously refreshed conversion efficiency levels, strategies focus on enhancing light absorptivity have been rarely discussed endow new direction for PTT. Herein, dimerization π‐extension strategy raised synthesize dimers with A‐D‐A monomers. We observe (ε) of strengthened three times owing enhanced coupling effect as result π‐conjugation extension, thereby surpassing 2‐fold increase in chromophore numbers from monomer dimers. Thanks enhancement absorption, could generate much more heat than vivo treatments. Therefore, anti‐tumor outcome fulfilled by under low (0.3 W/cm 2 ). Moreover, extended structures favorable radiative excited state decay, thus exhibiting distinguishing improvement imaging compared monomer. Collectively, due improved absorptivity, gain superior brightness over recently reported material, which goes beyond double doses applications. All these results prove effective designing high‐performance materials.

Language: Английский

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A planar electronic acceptor motif contributing to NIR-II AIEgen with combined imaging and therapeutic applications

Chemical Science, Journal Year: 2024, Volume and Issue: 15(18), P. 6777 - 6788

Published: Jan. 1, 2024

Designing molecules with donor-acceptor-donor (D-A-D) architecture plays an important role in obtaining second near-infrared region (NIR-II, 1000-1700 nm) fluorescent dyes for biomedical applications; however, this always comes a challenge due to very limited electronic acceptors. On the other hand, endow NIR-II combined therapeutic applications, trivial molecular design is indispensable. Herein, we propose pyrazine-based planar acceptor strong electron affinity, which can be used develop dyes. By structurally attaching two classical triphenylamine donors it, basic D-A-D module, namely Py-NIR, generated. The planarity of crucial induce distinct emission peaking at ∼1100 nm. unique construction cause twisted and flexible conformation by repulsive effect between donors, essential aggregation-induced (AIE) property. tuned intramolecular motions D-A pair brought lead remarkable photothermal conversion efficiency 56.1% type I photosensitization favorable hydroxyl radical (OH˙) formation. Note that no additional measures are adopted design, providing ideal platform realize probes synergetic functions based on such acceptor. Besides, nanoparticles Py-NIR exhibit excellent fluorescence imaging towards orthotopic 4T1 breast tumors living mice high sensitivity contrast. Combined photoacoustic caused thermal effect, imaging-guided photoablation well performed. Our work has created new opportunity accelerating applications.

Language: Английский

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Unlocking the NIR‐II AIEgen for High Brightness through Intramolecular Electrostatic Locking

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: May 8, 2024

Abstract Fluorescent imaging and biosensing in the near‐infrared‐II (NIR‐II) window holds great promise for non‐invasive, radiation‐free, rapid‐response clinical diagnosis. However, it's still challenging to develop bright NIR‐II fluorophores. In this study, we report a new strategy enhance brightness of aggregation‐induced emission (AIE) fluorophores through intramolecular electrostatic locking. By introducing sulfur atoms into side chains thiophene bridge TSEH molecule, molecular motion conjugated backbone can be locked interactions between nitrogen atoms. This leads enhanced fluorescent both solution aggregation states. Notably, encapsulated nanoparticles (NPs) show brightness, which is 2.6‐fold higher than TEH NPs with alkyl chains. The vivo experiments reveal feasibility vascular tumor high signal‐to‐background ratio precise resection tiny tumors. addition, polystyrene nanospheres are utilized antigen detection lateral flow assays, showing signal‐to‐noise 1.9‐fold counterpart detecting low‐concentration antigens. work highlights potential developing locking their applications diagnosis biomedical research.

Language: Английский

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Mitochondria-targeting near-infrared fluorescence/afterglow sensing assay for the rapid detection of HClO and its application in the early detection of Alzheimer's disease

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 415, P. 135995 - 135995

Published: May 17, 2024

Language: Английский

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Metalla‐Carbaporphyrinoids Consisting of an Acyclic N‐Confused Tetrapyrrole Analogue Served as Stable Near‐Infrared‐II Dyes

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(23)

Published: April 2, 2024

We present herein the synthesis of novel pseudo-metalla-carbaporphyrinoid species (1M: M=Pd and Pt) achieved through inner coordination palladium(II) platinum(II) with an acyclic N-confused tetrapyrrin analogue. Despite their tetrapyrrole frameworks being small, akin to well-known porphyrins, these exhibit unusually narrow HOMO-LUMO gap, resulting in unprecedentedly low-energy absorption second near-infrared (NIR-II) region. Density functional theory (DFT) calculations revealed unique d

Language: Английский

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Lighting up plants with near-infrared fluorescence probes

Science China Chemistry, Journal Year: 2023, Volume and Issue: 67(3), P. 774 - 787

Published: Oct. 23, 2023

Language: Английский

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Anthracene‐Fused Oligo‐BODIPYs: A New Class of π‐Extended NIR‐Absorbing Materials

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(5)

Published: Nov. 9, 2022

Large π-conjugated systems are key in the area of molecular materials. Herein, we prepare via AuI -catalyzed cyclization a series fully anthracene-fused oligo-BODIPYs. Their structural and optoelectronic properties were studied by several techniques, ranging from X-ray, UV/Vis, cyclic voltammetry to transient absorption spectroscopy. As complement, their electronic structures explored means Density Functional Theory (DFT) calculations. Depending on size shape skeleton, unique features-such as face-to-face supramolecular organization, NIR fluorescence well strong electron accepting character-were noted. All all, aforementioned features render them valuable for technological applications.

Language: Английский

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Tunable Nanomaterials of Intracellular Crystallization for In Situ Biolabeling and Biomedical Imaging

Chemical & Biomedical Imaging, Journal Year: 2023, Volume and Issue: 1(9), P. 767 - 784

Published: March 30, 2023

Intracellular biosynthetic nanomaterials offer tremendous opportunities for chemical biomedical imaging. A wide range of biologically active tissues are available biosynthesis, including cells, bacteria, plants, and viruses. Nanomaterials synthesized by intracellular biomineralization with outstanding biosafety optical properties attract unique attention. Herein, an overview tunable within biological imaging is presented. The synthetic mechanisms nanostructures summarized from the perspective different organisms. ability biosynthesis commonly used green synthesis metal nanoparticles compared to those physical or methods. characteristics these make it possible utilize them as fluorescence imaging, surface-enhanced Raman spectral mapping, nuclear magnetic resonance other photonics tools. Importantly, current issues, insights, future tendencies development presented based on This paper provides summary a critical assessment potential applications in this emerging field, laying foundation studies.

Language: Английский

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