Discovering Syntheses of Atomically Precise Metal Nanoclusters by Applying Machine Learning to a High‐Throughput Platform DOI
Li Tang, Li Wang, Bin Wang

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер unknown

Опубликована: Май 23, 2024

Understanding the complete structure of noble metal nanoclusters is both academically and practically significant. However, progress has been hindered by low synthetic efficiency many nanocluster syntheses. In this study, we present first high-throughput syntheses homo-gold, homo-copper, gold-copper alloy in dichloromethane at room temperature. Through screening, successfully obtained three a single reaction: Au

Язык: Английский

Ultrasmall Coinage Metal Nanoclusters as Promising Theranostic Probes for Biomedical Applications DOI
Yang Ge, Ziping Wang, Fanglin Du

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(22), С. 11879 - 11898

Опубликована: Май 18, 2023

Ultrasmall coinage metal nanoclusters (NCs, <3 nm) have emerged as a novel class of theranostic probes due to their atomically precise size and engineered physicochemical properties. The rapid advances in the design applications NC-based are made possible by atomic-level engineering NCs. This Perspective article examines (i) how functions NCs for applications, (ii) probe is designed its properties affect performance, (iii) used diagnose treat various diseases. We first summarize tailored terms biocompatibility tumor targeting. focus our discussion on bioimaging-directed disease diagnosis, photoinduced therapy, nanomedicine, drug delivery, optical urinalysis. Lastly, an outlook challenges opportunities future development provided.

Язык: Английский

Процитировано

86
Engineering Au44 Nanoclusters for NIR-II Luminescence Imaging-Guided Photoactivatable Cancer Immunotherapy DOI
Yang Ge,

Xinxin Pan,

Wenbi Feng

и другие.

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15605 - 15614

Опубликована: Июль 28, 2023

Immunotherapy is an advanced therapeutic strategy of cancer treatment but suffers from the issues off-target adverse effects, lack real-time monitoring techniques, and unsustainable response. Herein, ultrasmall Au nanocluster (NC)-based theranostic probe designed for second near-infrared window (NIR-II) photoluminescence (PL) imaging-guided phototherapies photoactivatable immunotherapy. The (Au44MBA26-NLG short) composed atomically precise NIR-II emitting Au44MBA26 NCs (here MBA denotes water-soluble 4-mercaptobenzoic acid) conjugated with immune checkpoint inhibitor 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (NLG919) via a singlet oxygen (1O2)-cleavable linker. Upon NIR photoirradiation, Au44MBA26-NLG not only enables PL imaging tumors in deep tissues guiding tumor therapy also allows leverage photothermal property (PTT) photogenerated 1O2 photodynamic (PDT) releasing NLG919 Such multiple effect modulated by prompts proliferation activation effector T cells, upshifts systemic antitumor T-lymphocyte (T cell) immunity, finally suppresses growth both primary distant living mice. Overall, this study may provide promising nanoplatform toward

Язык: Английский

Процитировано

59
Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes DOI
Wei Pan, Muhammad Rafiq,

Waqas Haider

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 514, С. 215907 - 215907

Опубликована: Май 12, 2024

Язык: Английский

Процитировано

33
Molecular Etching‐Derived High‐Brightness NIR‐II Gold Nanoclusters for High‐Resolution Bioimaging and Photothermal Therapy DOI Open Access

Fangzheng Tian,

S.Y. Li,

Xue Yang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract Glutathione‐capped gold nanoclusters (GSH‐Au NCs) with second near‐infrared (NIR‐II, 1000–1700 nm) fluorescence have received increasing interest in biomedical applications. However, conventional aqueous synthesis of GSH‐Au NCs results low NIR‐II absolute quantum yield (≈0.27%) and limited renal clearance efficiency (≈70%), which restricts its clinical This study reports a GSH‐etching post‐synthesis method to selectively convert nonfluorescent n ( > 25) into fluorescent 25 (eGSH‐Au NCs). molecular etching process decreases the size from 3.3 2.0 nm afforded 37% increase 11.9% enhancement efficiency. The optimized eGSH‐Au facilitates whole cerebrovascular imaging through scalp skull, tumor vasculature resolution 40.8 µm, dynamic perfusion signal‐to‐background ratio 10.5, enhanced lymphatic vessel lymph node imaging. Additionally, exhibit superior photothermal properties, achieving almost 100% growth inhibition Hepa1‐6 tumor‐bearing mice. presents novel strategy improve bioimaging therapeutic performance Au NCs, thus advancing their translation.

Язык: Английский

Процитировано

3
Enzyme-mimic catalytic activities and biomedical applications of noble metal nanoclusters DOI

Xinxin Pan,

Yidan Yao,

Manxi Zhang

и другие.

Nanoscale, Год журнала: 2024, Номер 16(17), С. 8196 - 8215

Опубликована: Янв. 1, 2024

This review delves into enzyme-mimic catalysis of metal nanoclusters based on a hierarchical structure scheme reminiscent proteins. Biomedical applications established by the clusters have also been outlined.

Язык: Английский

Процитировано

15
Intratumor injected gold molecular clusters for NIR-II imaging and cancer therapy DOI
Ani Baghdasaryan, Haoran Liu,

Fuqiang Ren

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(5)

Опубликована: Янв. 23, 2024

Surgical resections of solid tumors guided by visual inspection tumor margins have been performed for over a century to treat cancer. Near-infrared (NIR) fluorescence labeling/imaging in the NIR-I (800 900 nm) range with systemically administrated fluorophore/tumor-targeting antibody conjugates introduced improve margin delineation, removal accuracy, and patient survival. Here, we show Au 25 molecular clusters functionalized phosphorylcholine ligands (AuPC, ~2 nm size) as preclinical intratumorally injectable agent NIR-II/SWIR (1,000 3,000 imaging-guided resection. The AuPC were found be uniformly distributed 4T1 murine breast cancer upon intratumor (i.t.) injection. phosphocholine coating afforded highly stealth clusters, allowing high percentage fill interstitial fluid space homogeneously. Intra-operative surgical navigation imaging NIR-II allowed complete non-excessive also employed photothermal therapy (PTT) heat up eradicate tumors. Further, vivo NIR-IIb (1,500 1,700 treated using quantum dot-Annexin V (QD-P 3 -Anx V) conjugate, revealing cell apoptosis following PTT. therapeutic functionalities combined rapid renal excretion, biocompatibility, safety make them promising clinical translation.

Язык: Английский

Процитировано

14
Revolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives DOI Creative Commons

Ze‐Min Cai,

Zi‐Zhan Li, Nian‐Nian Zhong

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Март 29, 2024

Abstract The deployment of imaging examinations has evolved into a robust approach for the diagnosis lymph node metastasis (LNM). advancement technology, coupled with introduction innovative drugs, led to incorporation an increasingly diverse array techniques clinical practice. Nonetheless, conventional methods administering agents persist in presenting certain drawbacks and side effects. employment controlled drug delivery systems (DDSs) as conduit transporting offers promising solution ameliorate these limitations intrinsic metastatic (LN) imaging, thereby augmenting diagnostic precision. Within scope this review, we elucidate historical context LN encapsulate frequently employed DDSs conjunction variety techniques, specifically imaging. Moreover, engage discourse on conceptualization practical application fusing treatment by employing DDSs. Finally, venture prospective applications realm LNM share our perspective potential trajectory DDS development. Graphical

Язык: Английский

Процитировано

11
Gold Nanoclusters as High Resolution NIR-II Theranostic Agents DOI Creative Commons
Nancy Sharma,

Walaa Mohammad,

Xavier Le Guével

и другие.

Chemical & Biomedical Imaging, Год журнала: 2024, Номер 2(7), С. 462 - 480

Опубликована: Июнь 18, 2024

In the realm of nanomaterials, atomically precise quasi-molecular gold nanoclusters (AuNCs) play a prime role due to their unique, stable, and highly tunable optical properties. They are extensively structure-engineered for modulation surface electronic states toward long wavelength photoluminescence, particularly in NIR-II (1000 1700 nm) window. Contrast agents with emission can potentially transform imaging terms higher spatial resolution, deeper tissue penetration, reduced autofluorescence. These advantages allow real-time living organisms observing disease progression treatment response. this short review, we discuss origin rationally designed AuNCs application high resolution vasculatures hard soft structures identification pathological conditions such as stroke injury. Further, recent employment these rapidly growing field tumor theranostics is also summarized. Final remarks provided on scope improvement properties persisting challenges clinical translation.

Язык: Английский

Процитировано

10
Emerging NIR-II Luminescent Gold Nanoclusters for In Vivo Bioimaging DOI
Siqi Ni, Yizhuo Liu,

Shufen Tong

и другие.

Journal of Analysis and Testing, Год журнала: 2023, Номер 7(3), С. 260 - 271

Опубликована: Авг. 14, 2023

Язык: Английский

Процитировано

24
Phosphorylation of NIR‐II emitting Au nanoclusters for targeted bone imaging and improved rheumatoid arthritis therapy DOI Creative Commons
Yang Ge, Kang Liu, Yaru Wang

и другие.

Aggregate, Год журнала: 2023, Номер 5(2)

Опубликована: Окт. 5, 2023

Abstract Designing a theranostic probe for noninvasive bone imaging and disease therapy is both challenging desirable. Herein, an ultrasmall Au nanocluster (NC, <2 nm)‐based developed to achieve highly temporospatial in vivo bone‐targeted photoluminescence (PL) the second near‐infrared window (NIR‐II) enhanced rheumatoid arthritis (RA) therapy. The key design of involves surface phosphorylation atomically precise NIR‐II emitting 44 NCs. This enhances bone‐targeting ability due concentrated phosphate groups, allowing realize PL imaging. Moreover, benefiting from ability, hydrodynamic diameter, excellent anti‐inflammation immunomodulatory effects, not only demonstrates superior therapeutic efficacy RA rats, effectively restoring destructed cartilage nearly normal but also exhibits good renal clearance benign biocompatibility. These favorable attributes cannot be achieved by commercial methotrexate used treatment. study presents new paradigm metal NC‐based probes, offering potential high‐resolution improved

Язык: Английский

Процитировано

18