Опубликована: Янв. 1, 2024
Язык: Английский
Small, Год журнала: 2023, Номер 20(5)
Опубликована: Сен. 26, 2023
Abstract Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from worldwide. The prevalence pathogens has led to a significant increase in medical costs poses great threat normal life people. This is an important issue field biomedicine, emergence new antimicrobial materials hydrogels holds promise for solving this problem. Hydrogel material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, controlled release drugs as well structural diversity. Bacteria‐disturbing have applications direction surgical treatment, wound dressing, device coating, tissue engineering. paper reviews classification hydrogels, current status research, potential one application analyzes research biomedical five aspects: metal‐loaded drug‐loaded carbon‐material‐loaded fixed activity biological provides outlook high activity, biodegradability, injectability, clinical applicability future development prospects field.
Язык: Английский
Процитировано
48
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129300 - 129300
Опубликована: Янв. 11, 2024
Язык: Английский
Процитировано
26
Advanced Materials, Год журнала: 2024, Номер 36(21)
Опубликована: Фев. 16, 2024
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.
Язык: Английский
Процитировано
21
Biomaterials Science, Год журнала: 2023, Номер 12(1), С. 8 - 56
Опубликована: Окт. 25, 2023
Hydrogels have established their significance as prominent biomaterials within the realm of biomedical research. However, injectable hydrogels garnered greater attention compared with conventional counterparts due to excellent minimally invasive nature and adaptive behavior post-injection. With rapid advancement emerging chemistry deepened understanding biological processes, contemporary been endowed an "intelligent" capacity respond various endogenous/exogenous stimuli (such temperature, pH, light magnetic field). This innovation has spearheaded revolutionary transformations across fields such tissue engineering repair, controlled drug delivery, disease-responsive therapies, beyond. In this review, we comprehensively expound upon raw materials (including natural synthetic materials) principles these advanced hydrogels, concurrently providing a detailed discussion prevalent strategies for conferring stimulus responsiveness. Finally, elucidate latest applications "smart" stimuli-responsive in domain, offering insights into prospects.
Язык: Английский
Процитировано
29
Gels, Год журнала: 2024, Номер 10(11), С. 693 - 693
Опубликована: Окт. 25, 2024
Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.
Язык: Английский
Процитировано
9
Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2623 - 2623
Опубликована: Ноя. 14, 2023
Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages therapeutic delivery. These encompassing platforms such liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, enhanced outcomes. However, translation BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, rigorous efficacy safety evaluations. Furthermore, innovative nature demands reevaluation evolution existing regulatory ethical frameworks. This review provides an overview delves into multifaceted translational challenges present emerging solutions, underscored real-world case studies. Emphasizing potential redefine healthcare, we advocate sustained interdisciplinary collaboration research. As our understanding deepens, future appears promising, focus on personalized medicine refined patient-specific systems.
Язык: Английский
Процитировано
19
Chemistry of Materials, Год журнала: 2024, Номер 36(3), С. 1054 - 1087
Опубликована: Янв. 16, 2024
The field of tissue engineering and regenerative medicine is rapidly advancing, with numerous novel intriguing biomimetic materials being reported. Hydrogels, due to their unique structure properties closely resembling biological tissues, stand as prime candidates for mimicking natural tissues in applications. In recent years, drawing inspiration from the intricate structures found soft researchers have successfully created a range hydrogels. These hydrogels been tailored diverse applications fields such biomedicine, engineering, flexible electronic devices, beyond. However, designing fabricating synthetic structures, dynamic microenvironment systems, integrated functionalities remains challenging. This article presents latest research progress macroscopic structural hydrogels, well along most construction strategies, key design principles, optimization mechanisms. It summarizes potential various domains repair, signal detection sensing, drug delivery, more. Lastly, challenges future development directions preparation application are outlined.
Язык: Английский
Процитировано
7
Smart Medicine, Год журнала: 2023, Номер 2(4)
Опубликована: Окт. 7, 2023
Abstract Hydrogel adhesives are extensively employed in biological interfaces such as epidermal flexible electronics, tissue engineering, and implanted device. The development of functional hydrogel is a critical, yet challenging task since combining two or more attributes that seem incompatible into one adhesive without sacrificing the hydrogel's pristine capabilities. In this Review, we highlight current developments fabrication hydrogels, which suitable for variety application scenarios, particularly those occur underwater on tissue/organ surface conditions. design strategies multifunctional with desirable properties including adhesion, self‐healing, good biocompatibility, electrical conductivity, anti‐swelling discussed comprehensively. We then discuss challenges faced by well their potential applications interfaces. Adhesive hydrogels star building blocks bio‐interface materials individualized healthcare other bioengineering areas.
Язык: Английский
Процитировано
14
Regenerative Biomaterials, Год журнала: 2024, Номер 11
Опубликована: Янв. 1, 2024
Abstract Decellularized extracellular matrix hydrogel, especially that derived from spinal cord (DSCM hydrogel), has been actively considered as a functional biomaterial for remodeling the of native tissue, due to its unique characteristics in constructing pro-regenerative microenvironment neural stem cells (NSCs). Furthermore, DSCM hydrogel can provide multiple binding domains growth factors and drugs. Therefore, both exogenous neurotrophic anti-inflammatory drugs are highly desired be incorporated into which may synergistically modulate complex at lesion site after injury (SCI). Herein, neurotrophin-3 (NT-3) curcumin (Cur) were integrated SCI therapy. Due different affinities NT-3 underwent controlled release manner, while released explosively within first 24 h, followed by rather sustained but slower release. The integration significantly enhanced NSCs proliferation their neuronal differentiation. Meanwhile, promoted macrophages polarization subtypes, further facilitated differentiation neurons. situ injected + NT3 Cur exerted superior capability alleviating inflammatory responses rat contused cord. Compared alone, more recruitment site. These outcomes favored recovery, evidenced improved hind limb movement. Overall, bioactive serve multifunctional carrier cooperatively drugs, benefits regulation nerve regeneration SCI.
Язык: Английский
Процитировано
5
Biomedical Materials, Год журнала: 2024, Номер 19(2), С. 025016 - 025016
Опубликована: Янв. 12, 2024
Traumatic brain injury (TBI) produces excess iron, and increased iron accumulation in the leads to lipid peroxidation reactive oxygen species (ROSs), which can exacerbate secondary damage lead disability death. Therefore, inhibition of overload oxidative stress has a significant role treatment TBI. Functionalized hydrogels with inhibiting ability will greatly contribute repair Herein, an injectable, post-traumatic microenvironment-responsive, ROS-responsive hydrogel encapsulated deferrioxamine mesylate (DFO) was developed. The is rapidly formed via dynamic covalent bonding between phenylboronic acid grafted hyaluronic (HA-PBA) polyvinyl alcohol (PVA), phenylboronate bonds are used respond reduce ROS levels damaged tissue promote neuronal recovery. release DFO from HA-PBA/PVA response further promotes regeneration recovery by relieving thus eradicating ROS. In Feeney model Sprague Dawley rats, HA-PBA/PVA/DFO significantly improved behavior TBI rats reduced area contusion rats. addition, could effectively Its effects were also explored, notably, as well ROS, protecting neurons Thus, this biocompatible drug-loaded great potential for This work suggests novel method after
Язык: Английский
Процитировано
4