New Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Hydrogel films were prepared using mucoadhesive extracts from fenugreek and flax seeds, their versatility for a range of biological uses – such as anti-inflammatory, anti-diabetic, anti-oxidant, anti-microbial applications was examined.
Язык: Английский
Biomaterials, Год журнала: 2025, Номер 318, С. 123195 - 123195
Опубликована: Фев. 15, 2025
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(3), С. 207 - 207
Опубликована: Март 15, 2025
Hydrogels are innovative materials characterized by a water-swollen, crosslinked polymeric network capable of retaining substantial amounts water while maintaining structural integrity. Their unique ability to swell or contract in response environmental stimuli makes them integral biomedical applications, including drug delivery, tissue engineering, and wound healing. Among these, “smart” hydrogels, sensitive such as pH, temperature, light, showcase reversible transitions between liquid semi-solid states. Thermoresponsive exemplified poly(N-isopropylacrylamide) (PNIPAM), particularly notable for their sensitivity temperature changes, transitioning near lower critical solution (LCST) approximately 32 °C water. Structurally, PNIPAM-based hydrogels (PNIPAM-HYDs) chemically versatile, allowing modifications that enhance biocompatibility functional adaptability. These properties enable application diverse therapeutic areas cancer therapy, phototherapy, healing, engineering. In this review, the behavior smart PNIPAM explored, with an emphasis on synthesis methods brief note biocompatibility. Furthermore, PNIPAM-HYDs detailed, along applications skin conditions, ocular diseases, etc. Various delivery routes patents highlighting advancements also examined. Finally, future prospects remain promising, ongoing research focused enhancing stability, responsiveness, clinical applicability. continued development is expected revolutionize technologies, paving way more efficient targeted solutions.
Язык: Английский
Процитировано
0
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 290, С. 117535 - 117535
Опубликована: Март 20, 2025
Cancer drug delivery remains a critical challenge with systemic toxicity, poor bioavailability, and lack of effective targeting. Overcoming these barriers is essential for improving treatment efficacy patient outcomes. This review discusses current techniques that reshape cancer therapy by offering precise, controlled-release tailored to tumor-specific features. Innovations in nanotechnology, immunotherapy, gene enable interventions at molecular cellular levels. Radiomics pathomics integrate high-dimensional data optimize diagnostics planning. Combination addresses the complexities tumor heterogeneity synergizing multiple agents within single therapeutic framework, while peptide-drug conjugates enhance specificity potency. Hydrogel-based systems microneedle arrays offer localized, sustained release, significantly However, clinical translation advancements faces significant such as resistance, off-target effects, scalability, cost, ethical concerns. Moreover, regulatory economic feasibility therapies highlight need innovative frameworks make them accessible globally. Therefore, there innovation cell therapy, next-generation platforms, personalized medicine. focuses on recent over past decade, evaluating their limitations exploring potential future directions transforming treatment.
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their appeal lies their biocompatibility, adjustable mechanical properties, capacity to respond external stimuli, including pH, temperature, light, redox potential, ionic strength, enzymatic activity. These features enable enhanced targeted bioactive agents. This mini-review evaluates synthesis injectable well recent advancements treating range bone disorders, focusing on mechanisms sustained DDSs delivering drugs, nanoparticles, growth factors, cells (e.g., stem cells). Moreover, it highlights clinical studies disease treatment. Additionally, emphasizes potential synergy between hydrogel-based point-of-care technologies, which are anticipated play pivotal role future therapies. have transform treatment by facilitating precise, sustained, minimally invasive therapeutic delivery. Nevertheless, significant challenges, long-term scalability, reproducibility, precise regulation release kinetics, must be addressed unlock fully. Addressing these challenges will not only advance therapy but also open new avenues regenerative medicine personalized healthcare.
Язык: Английский
Процитировано
0
Materials Today Chemistry, Год журнала: 2025, Номер 46, С. 102704 - 102704
Опубликована: Апрель 15, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132086 - 132086
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
3
Journal of Materials Science, Год журнала: 2024, Номер 59(35), С. 16449 - 16471
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
3
Soft Matter, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Phenylboronic acid (PBA) is a widely exploited glucose-sensitive element for constructing glucose-responsive hydrogels to enable smart insulin delivery.
Язык: Английский
Процитировано
3
Journal of Macromolecular Science Part A, Год журнала: 2024, Номер 61(7), С. 493 - 502
Опубликована: Июнь 3, 2024
The work aims to develop a biopolymer-dextrin-based three-dimensional crosslinked hydrophilic material for antimicrobial delivery. copolymer (Dxt-PNVA) has been prepared by in-situ grafting of poly(N-vinylacetamide), followed cross-linking with N,N'-methylenebisacrylamide dextrin. By varying the concentrations reactants, an optimized (Dxt-PNVA 5) lowest % crosslinking chosen biomedical applications. copolymeric gel characterized in detail using various techniques, its cytocompatibility study HeLa Cell lines that confirm cytocompatible nature material. Copolymeric is suitable effective release two antimicrobials (amoxicillin trihydrate and ornidazole) from tablet formulation prolonged period 24 h. obtained data demonstrates hydrogel potential characteristics daily dose administration amoxicillin ornidazole.
Язык: Английский
Процитировано
2
Nanoscale, Год журнала: 2024, Номер 16(28), С. 13613 - 13626
Опубликована: Янв. 1, 2024
Over the past several years, a significant increase in expanding field of biomaterial sciences has been observed due to development biocompatible materials based on peptide derivatives that have intrinsic therapeutic potential.
Язык: Английский
Процитировано
2