Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences,
Год журнала:
2024,
Номер
480(2304)
Опубликована: Дек. 1, 2024
This
study
systematically
investigates,
both
analytically
and
numerically,
transdermal
drug
delivery
using
a
microneedle
(MN)
array.
The
released
from
the
MN
tip
disperses
through
viable
skin
before
being
absorbed
in
blood
compartment.
Reversible
uptake
kinetics
between
tissue
compartments,
together
with
reversible
specific
binding
of
its
receptors
tissue,
have
been
taken
into
account.
governing
equations
are
solved
numerically
an
explicit
manner.
Simulations
predict
that
metabolism
skin,
irreversible
stabilizing
effect
on
free
bound
verapamil
concentrations.
In
addition,
longer
larger
skin–blood
interface
area
contribute
to
higher
concentrations
all
forms
compartments.
results
suggest
lack
compartment
might
overestimate
verapamil.
A
thorough
sensitivity
analysis
has
performed
account
for
uncertainties
some
parameters
involved.
retention
relationship
length
MN,
time
application,
interface,
rate
compartments
constitute
novel
aspect
this
analytical
numerical
work.
Our
reduced
model
is
excellent
agreement
available
literature.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Phytochemicals,
which
are
predominantly
found
in
plants,
hold
substantial
medicinal
value.
Despite
their
potential,
challenges
such
as
poor
oral
bioavailability
and
instability
the
gastrointestinal
tract
have
limited
therapeutic
use.
Traditional
intra/transdermal
drug
delivery
systems
offer
some
advantages
over
administration
but
still
suffer
from
issues
penetration
depth,
slow
release
rates,
inconsistent
absorption.
In
contrast,
microneedles
(MNs)
represent
a
significant
advancement
by
providing
precise
control
phytochemical
enhanced
capabilities.
By
circumventing
skin
barriers,
MNs
directly
access
dermal
layers
rich
blood
vessels
lymphatics,
thus
facilitating
efficient
delivery.
This
review
extensively
discusses
obstacles
of
traditional
benefits
routes
with
particular
focus
on
transformative
potential
for
explores
complexities
delivering
phytochemicals
through
routes,
development
types
innovative
tools,
optimal
design
properties
effective
Additionally,
this
examines
versatile
applications
MN-mediated
delivery,
including
its
role
administering
phytophotosensitizers
photodynamic
therapy,
concludes
insights
into
relevant
patents
future
perspectives.
Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences,
Год журнала:
2024,
Номер
480(2304)
Опубликована: Дек. 1, 2024
This
study
systematically
investigates,
both
analytically
and
numerically,
transdermal
drug
delivery
using
a
microneedle
(MN)
array.
The
released
from
the
MN
tip
disperses
through
viable
skin
before
being
absorbed
in
blood
compartment.
Reversible
uptake
kinetics
between
tissue
compartments,
together
with
reversible
specific
binding
of
its
receptors
tissue,
have
been
taken
into
account.
governing
equations
are
solved
numerically
an
explicit
manner.
Simulations
predict
that
metabolism
skin,
irreversible
stabilizing
effect
on
free
bound
verapamil
concentrations.
In
addition,
longer
larger
skin–blood
interface
area
contribute
to
higher
concentrations
all
forms
compartments.
results
suggest
lack
compartment
might
overestimate
verapamil.
A
thorough
sensitivity
analysis
has
performed
account
for
uncertainties
some
parameters
involved.
retention
relationship
length
MN,
time
application,
interface,
rate
compartments
constitute
novel
aspect
this
analytical
numerical
work.
Our
reduced
model
is
excellent
agreement
available
literature.
